DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir25a and Grik1

DIOPT Version :9

Sequence 1:NP_001260049.1 Gene:Ir25a / 33683 FlyBaseID:FBgn0031634 Length:947 Species:Drosophila melanogaster
Sequence 2:NP_001104587.1 Gene:Grik1 / 29559 RGDID:2732 Length:949 Species:Rattus norvegicus


Alignment Length:990 Identity:260/990 - (26%)
Similarity:424/990 - (42%) Gaps:233/990 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 ILMNPKTSKILWLLGFLSLLSSFSLEIAAQTTQNINVL--FINEVDNEPA---AKAVEVVLTYLK 61
            :|:.|.    ||.......|..|...|..||:..:..:  ....|:|||.   ..|.:..:|.:.
  Rat     6 VLIQPG----LWTRDTSWTLLYFLCYILPQTSPQVLRIGGIFETVENEPVNVEELAFKFAVTSIN 66

  Fly    62 KN--------IRYGLS-VQL-DSIEANKSDAKVLLEAICNKYATSIEKKQTPHLILDTTKSGIAS 116
            :|        :.|.:. :.| ||.||::        ..|::.|..:.....|     :..|.:::
  Rat    67 RNRTLMPNTTLTYDIQRINLFDSFEASR--------RACDQLALGVAALFGP-----SHSSSVSA 118

  Fly   117 ETVKSFTQALGLPTISASYGQQGDLRQWRDLD-EAKQKYLLQVMPPADIIPEAIRSIVIHMNITN 180
              |:|...||.:|.|..         :|:... :::..:.:.:.|....|..|:..:|::.|...
  Rat   119 --VQSICNALEVPHIQT---------RWKHPSVDSRDLFYINLYPDYAAISRAVLDLVLYYNWKT 172

  Fly   181 AAILYDDSFVMDHKYKSLLQNIQTRHVITAIAKDGKREREEQIEKLRNLDINNFFILGTLQSIRM 245
            ..::|:||..:          |:.:.:|.|.::...:      .|:|.|...|       :..:.
  Rat   173 VTVVYEDSTGL----------IRLQELIKAPSRYNIK------IKIRQLPPAN-------KDAKP 214

  Fly   246 VLESVKPAYFERNFAWHAITQNEGEISSQRDNATIMFMKPMA-YTQYRDRLGLLRTTYNLNEEPQ 309
            :|:.:|.:. |....:....:...||..|     |:||..|. |..|      ..||.:|     
  Rat   215 LLKEMKKSK-EFYVIFDCSHETAAEILKQ-----ILFMGMMTEYYHY------FFTTLDL----- 262

  Fly   310 LSSAFYFDLALRSFLTIKEMLQSGAWPKDMEYLNCDD--------------FQGGNTPQRNLDLR 360
                |..||.|..:        ||........||.|:              .|....|:..| |.
  Rat   263 ----FALDLELYRY--------SGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGL-LD 314

  Fly   361 DYFTKITEP------------TSYGTFDLVTQSTQ-----PFN-GHSFMK--------------- 392
            ...|  ||.            .|:....|...|.|     |:. |..||.               
  Rat   315 GMMT--TEAALMYDAVYMVAIASHRASQLTVSSLQCHRHKPWRLGPRFMNLIKEARWDGLTGRIT 377

  Fly   393 ----------FEMDINVLQIRGGSSVNS----------KSIGKWISGLNSELIVKD--EEQMKNL 435
                      |::||..|:..|....:.          |.||.|.|  ||.|.:.|  .::..|:
  Rat   378 FNKTDGLRKDFDLDIISLKEEGTEKASGEVSKHLYKVWKKIGIWNS--NSGLNMTDGNRDRSNNI 440

  Fly   436 T---ADTVYRIFTVVQAPFIM-RDETAP----KGYKGYCIDLINEIAAIVHFDYTIQEVEDGKFG 492
            |   |:....:.|:::.|::| |....|    ..::|||:||:.|::.|:.|.|.::.|.|||:|
  Rat   441 TDSLANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFLYDVKLVPDGKYG 505

  Fly   493 NMDENGQWNGIVKKLMDKQADIGLGSMSVMAEREIVIDFTVPYYDLVGITIMMQRPSSPS-SLFK 556
            ..::.|:|||:||:|:|.:||:.:..:::...||.||||:.|:..| ||:|:.::|:..: .:|.
  Rat   506 AQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTL-GISILYRKPNGTNPGVFS 569

  Fly   557 FLTVLETNVWLCILAAYFFTSFLMWIFDRWSPYSYQNNREKYKD-DEEKREFNLKECLWFCMTSL 620
            ||..|..::|:.:|.|....|.::::..|::||.:.|......| |..:..|.|....||.:.:|
  Rat   570 FLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGAL 634

  Fly   621 TPQGGGEAPKNLSGRLVAATWWLFGFIIIASYTANLAAFLTVSRLDTPVESLDDLAKQYKILYAP 685
            ..||....||.||.|:|...||.|..|||:||||||||||||.|:::|::|.||||||.||.|..
  Rat   635 MQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGA 699

  Fly   686 LNGSSAMTYFERMSNIEQMFYEIWKDLSLNDSLTAVERSKLAVWDYPVSDKYTKMWQAM---QEA 747
            :...|.||:|                          ::||::.        |.|||..|   |::
  Rat   700 VRDGSTMTFF--------------------------KKSKIST--------YEKMWAFMSSRQQS 730

  Fly   748 KLPATLDEAVARVRNSTAATGFAFLGDATDIRYLQLTNCDLQVVGEEFSRKPYAIAVQQGSHLKD 812
            .|....||.:.||    ..|.:|.|.::|.|.|:...||:|..:|.....|.|.:....||..:|
  Rat   731 ALVKNSDEGIQRV----LTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRD 791

  Fly   813 QFNNAILTLLNKRQLEKLKEKWWKNDEALAKCDKPEDQS---DGISIQNIGGVFIVIFVGIGMAC 874
            :...|||.|..:.:|..:|||||:.:..      ||:.|   ..:.::||||:|||:..|:.::.
  Rat   792 KITIAILQLQEEGKLHMMKEKWWRGNGC------PEEDSKEASALGVENIGGIFIVLAAGLVLSV 850

  Fly   875 ITLVFEYWWYRYRKN 889
            ...:.|: .|:.|||
  Rat   851 FVAIGEF-LYKSRKN 864

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
Ir25aNP_001260049.1 PBP1_iGluR_AMPA_Like 40..426 CDD:107378 91/467 (19%)
PBP2_iGluR_putative 438..836 CDD:270435 139/407 (34%)
Lig_chan 565..870 CDD:278489 105/311 (34%)
Grik1NP_001104587.1 Periplasmic_Binding_Protein_Type_1 35..430 CDD:299141 91/475 (19%)
ANF_receptor 53..396 CDD:279440 77/421 (18%)
Periplasmic_Binding_Protein_Type_2 446..815 CDD:304360 139/407 (34%)
Glutamate binding 531..533 0/1 (0%)
Lig_chan 577..846 CDD:278489 105/312 (34%)