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Protein Alignment Ir25a and GRIN2D

DIOPT Version :9

Sequence 1:	NP_001260049.1	Gene:	Ir25a / 33683	FlyBaseID:	FBgn0031634	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	NP_000827.2	Gene:	GRIN2D / 2906	HGNCID:	4588	Length:	1336	Species:	Homo sapiens

Alignment Length:	615	Identity:	144/615 - (23%)
Similarity:	245/615 - (39%)	Gaps:	152/615 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   346 DFQGGNTPQRNLDLRDYFTKIT-EPTSYGTFDLVTQSTQPFNGHSFMKFEMDINVLQIRGGSSVN 409
            |.:..|...|...|..||..|| :...|.           ||...|:   ::.:::.|.......
Human   347 DCRAQNRTHRGESLHRYFMNITWDNRDYS-----------FNEDGFL---VNPSLVVISLTRDRT 397

  Fly   410 SKSIGKWISGLNSELIVKDEEQMKNL--------------TADTVY-RIFTVVQAPFI------- 452
            .:.:|.|            |:|...|              ..||.: .:.|:.:.||:
Human   398 WEVVGSW------------EQQTLRLKYPLWSRYGRFLQPVDDTQHLTVATLEERPFVIVEPADP 450

  Fly   453 -----MRDET---------------APKG----YKGYCIDLINEIAAIVHFDYTIQEVEDGKFGN 493
                 :||..               ||:.    .||:|||::..:|..:.|.|.:..|.:||.|.
Human   451 ISGTCIRDSVPCRSQLNRTHSPPPDAPRPEKRCCKGFCIDILKRLAHTIGFSYDLYLVTNGKHGK 515

  Fly   494 MDENGQWNGIVKKLMDKQADIGLGSMSVMAEREIVIDFTVPYYDLVGITIMMQRPSSPSSLFKFL 558
            ..: |.|||::.::..::||:.:||:::..||..::||:||:.: .||::|:.|.:...|...||
Human   516 KID-GVWNGMIGEVFYQRADMAIGSLTINEERSEIVDFSVPFVE-TGISVMVARSNGTVSPSAFL 578

  Fly   559 TVLETNVW-----LCILAAYFFTSFLMWIFDRWSPYSYQNNREKYKDDEEKREFNLKECLW---- 614
            ......||     :|:..    .:..::||:..||..|..:....|..... .|.:.:.:|
Human   579 EPYSPAVWVMMFVMCLTV----VAVTVFIFEYLSPVGYNRSLATGKRPGGS-TFTIGKSIWLLWA 638

  Fly   615 FCMTSLTPQGGGEAPKNLSGRLVAATWWLFGFIIIASYTANLAAFLTVSRLDTPVESLDDLAKQY 679
            ....:..|.   |.|:..:.:::...|..|..|.:||||||||||:........|..|.|...|.
Human   639 LVFNNSVPV---ENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDRKFQR 700

  Fly   680 -KILYAPL------NGSSAMTYFERMSNIEQMFYEIWKDLSLNDSLTAVERSKLAVWDYPVSDKY 737
             :..|.||      |||:.       .||..                          :||  |.:
Human   701 PQEQYPPLKFGTVPNGSTE-------KNIRS--------------------------NYP--DMH 730

  Fly   738 TKMWQAMQEAKLPATLDEAVARVRNSTAATGFAFLGDATDIRYLQLTN--CDLQVV--GEEFSRK 798
            :.|.:..|     ..::||:.:::   |....||:.||..:.|:...:  |.|..:  |:.|:..
Human   731 SYMVRYNQ-----PRVEEALTQLK---AGKLDAFIYDAAVLNYMARKDEGCKLVTIGSGKVFATT 787

  Fly   799 PYAIAVQQGSHLKDQFNNAILTLLNKRQLEKLKEKWWKNDEALAKCDKPEDQSDGISIQNIGGVF 863
            .|.||:.:||..|...:.|:|..|...::|.|:..|.   ..:...||.|..|..:.|.|:.|||
Human   788 GYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLWL---SGICHNDKIEVMSSKLDIDNMAGVF 849

  Fly   864 IVIFVGIGMACITLVFE---YWWYRYRKNP 890
            .::.|.:|::.:...:|   ||..|:...|
Human   850 YMLLVAMGLSLLVFAWEHLVYWRLRHCLGP 879

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.