Protein Alignment Ir25a and GRIN2B

DIOPT Version :10

• Sequence 1: NP_001260049.1
• Gene: Ir25a / 33683
• FlyBaseID: FBgn0031634
• Length: 947
• Species: Drosophila melanogaster
• Sequence 2: NP_000825.2
• Gene: GRIN2B / 2904
• HGNCID: 4586
• Length: 1484
• Species: Homo sapiens
• Alignment Length: 1001
• Identity: 226/1001 - (22%)
• Similarity: 383/1001 - (38%)
• Gaps: 271/1001 - (27%)

  Fly     4 MNPKT---SKILWL-LGFLSLLSSFSLEIAAQTTQNINVLFINEVDNEPAAKAVEVVLTYLKKNI 64
            |.|:.   |...|| |..|::..|.:....:..:..|.|:.:...| |.|.|...      :|:.
Human     1 MKPRAECCSPKFWLVLAVLAVSGSRARSQKSPPSIGIAVILVGTSD-EVAIKDAH------EKDD 58

  Fly    65 RYGLSV--QLDSIEANKSDAKVLLEAICNKYATSIEKKQTPHLILDTTKSGIASETVKSFTQALG 127
            .:.|||  :::.:..|::|.|.::..||:  ..|..|.|......||.:..||.  :..|..|..
Human    59 FHHLSVVPRVELVAMNETDPKSIITRICD--LMSDRKIQGVVFADDTDQEAIAQ--ILDFISAQT 119

  Fly   128 LPTISASYGQQGDLRQWRDLDEAKQKY------------LLQVMPPADIIPEAIRSIVIHMNITN 180
            |..|...:|  |......|.||:...:            :|.:|...|..   |.|||     |.
Human   120 LTPILGIHG--GSSMIMADKDESSMFFQFGPSIEQQASVMLNIMEEYDWY---IFSIV-----TT 174

  Fly   181 AAILYDDSFVMDHKYKSLLQN------IQTRHVITAIAKDGKREREEQIEKLRNLDINNFFILGT 239
            ....|.| ||  :|.:|.::|      ::...::.....||..:.:.|::||::..|..:.....
Human   175 YFPGYQD-FV--NKIRSTIENSFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSPIILLYCTKEE 236

  Fly   240 LQSIRMVLESVKPAYFERNFAWHAITQNEGEISSQRDNATIMFMKP-----MAYTQY-------- 291
            ...|..|..||....:  .:.|...:...|      |..|:....|     ::|.::
Human   237 ATYIFEVANSVGLTGY--GYTWIVPSLVAG------DTDTVPAEFPTGLISVSYDEWDYGLPARV 293

  Fly   292 RDRLGLLRTTYNLNEEPQLSSAFYFDLALRSFLTIKEMLQSGAW---PKDMEYLNCDDFQGGNTP 353
            ||.:.::.|                        ...:||...::   ||...|         ||.
Human   294 RDGIAIITT------------------------AASDMLSEHSFIPEPKSSCY---------NTH 325

  Fly   354 QRNL----DLRDYFTKITEPTSYGTFDLVTQSTQPFNGH--SFMK--FEMDINVLQIRGGSSVNS 410
            ::.:    .|..|...:|                 |.|.  ||.:  ::|...::.|........
Human   326 EKRIYQSNMLNRYLINVT-----------------FEGRNLSFSEDGYQMHPKLVIILLNKERKW 373

  Fly   411 KSIGKWISGLNSELIVKDEE-QMKNLT-----------ADTVYRIFTVVQAPFIMRDETAP---- 459
            :.:|||          ||:. |||...           .|....|.|:.:|||::.:...|
Human   374 ERVGKW----------KDKSLQMKYYVWPRMCPETEEQEDDHLSIVTLEEAPFVIVESVDPLSGT 428

  Fly   460 ---------------------KGY-----KGYCIDLINEIAAIVHFDYTIQEVEDGKFGNMDENG 498
                                 .||     ||:|||::.:|:..|.|.|.:..|.:||.|. ..||
Human   429 CMRNTVPCQKRIVTENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLYLVTNGKHGK-KING 492

  Fly   499 QWNGIVKKLMDKQADIGLGSMSVMAEREIVIDFTVPYYDLVGITIMMQRPSSPSSLFKFLTVLET 563
            .|||::.:::.|:|.:.:||:::..||..|:||:||:.: .||::|:.|.:...|...||.....
Human   493 TWNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIE-TGISVMVSRSNGTVSPSAFLEPFSA 556

  Fly   564 NVWLCILAAYFFTSFL-MWIFDRWSPYSYQNNREKYKDDEEK--REFNLKECLWFCM-----TSL 620
            :||:.:.......|.: :::|:.:||..|  || ...|..|.  ..|.:.:.:|...     .|:
Human   557 DVWVMMFVMLLIVSAVAVFVFEYFSPVGY--NR-CLADGREPGGPSFTIGKAIWLLWGLVFNNSV 618

  Fly   621 TPQGGGEAPKNLSGRLVAATWWLFGFIIIASYTANLAAFLTVSRLDTPVESLDDLAKQYKILYAP 685
            ..|.    ||..:.:::.:.|..|..|.:||||||||||:........|..|.|...|....::|
Human   619 PVQN----PKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEYVDQVSGLSDKKFQRPNDFSP 679

  Fly   686 -------LNGSSAMTYFERMSNIEQMFYEI------WKDLSLNDSLTAVERSKLAVWDYPVSDKY 737
                   .|||:     ||  ||...:.|:      :....::|:|.:::..||.
Human   680 PFRFGTVPNGST-----ER--NIRNNYAEMHAYMGKFNQRGVDDALLSLKTGKLD---------- 727

  Fly   738 TKMWQAMQEAKLPATLDEAVARVRNSTAATGFAFLGDATDIRYL--QLTNCDLQVV--GEEFSRK 798
                                            ||:.||..:.|:  :...|.|..:  |:.|:..
Human   728 --------------------------------AFIYDAAVLNYMAGRDEGCKLVTIGSGKVFAST 760

  Fly   799 PYAIAVQQGSHLKDQFNNAILTLLNKRQLEKLKEKWWKNDEALAKCDKPEDQSDGISIQNIGGVF 863
            .|.||:|:.|..|.|.:.|||.|....::|:|:..|.   ..:...:|.|..|..:.|.|:.|||
Human   761 GYGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALWL---TGICHNEKNEVMSSQLDIDNMAGVF 822

  Fly   864 IVIFVGIGMACITLVFE---YWWYRY 886
            .::...:.::.||.:.|   ||.:|:
Human   823 YMLGAAMALSLITFICEHLFYWQFRH 848

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	37..418	CDD:380606	83/424 (20%)
		PBP2_iGluR_putative	438..836	CDD:270435	115/452 (25%)
GRIN2B	NP_000825.2	PBP1_iGluR_NMDA_NR2	33..388	CDD:380601	88/446 (20%)
		PBP2_iGluR_NMDA_Nr2	403..803	CDD:270436	115/460 (25%)
		Pore-forming. /evidence=ECO:0000250|UniProtKB:A7XY94	604..623		3/22 (14%)
		NMDAR2_C	840..1484	CDD:463148	3/9 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1074..1097
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1161..1194
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1271..1301
		Interaction with DAPK1. /evidence=ECO:0000250|UniProtKB:Q01097	1292..1304
		PDZ-binding. /evidence=ECO:0000250	1482..1484