Protein Alignment Ir25a and GRIN2A

DIOPT Version :9

• Sequence 1: NP_001260049.1
• Gene: Ir25a / 33683
• FlyBaseID: FBgn0031634
• Length: 947
• Species: Drosophila melanogaster
• Sequence 2: XP_016878661.1
• Gene: GRIN2A / 2903
• HGNCID: 4585
• Length: 1516
• Species: Homo sapiens
• Alignment Length: 991
• Identity: 203/991 - (20%)
• Similarity: 368/991 - (37%)
• Gaps: 290/991 - (29%)

  Fly    68 LSVQLDSIEANKSDAKVLLEAICNKYATSIEKKQTPHLIL--DTTKSGIAS--ETVKS--FTQAL 126
            |.|.:.::..|::|.|.|:..:|:..:.:    :...|:.  ||.:..:|.  :.:.|  |...|
Human   117 LDVNVVALLMNRTDPKSLITHVCDLMSGA----RIHGLVFGDDTDQEAVAQMLDFISSHTFVPIL 177

  Fly   127 GL------------PT-----ISASYGQQGDLRQWRDLDEAKQKYLLQVMPPAD---------II 165
            |:            ||     ..||..||..:             :|::|...|         |.
Human   178 GIHGGASMIMADKDPTSTFFQFGASIQQQATV-------------MLKIMQDYDWHVFSLVTTIF 229

  Fly   166 PEAIRSIV--IHMNITNAAILYD-------DSFVMDHKYKSLLQNIQTRHVITAIAKDGKREREE 221
            | ..|..:  :...:.|:.:.:|       |:...|.|.:..|:.|.:..::...:||   |...
Human   230 P-GYREFISFVKTTVDNSFVGWDMQNVITLDTSFEDAKTQVQLKKIHSSVILLYCSKD---EAVL 290

  Fly   222 QIEKLRNLDINNFFILGTLQSIRMVLESVKPAYFERNFAWHAITQNEGEISSQRDNATIMFMKPM 286
            .:.:.|:|.:..:.....:.|:......:.|..|.....  :::.::.:.|.:
Human   291 ILSEARSLGLTGYDFFWIVPSLVSGNTELIPKEFPSGLI--SVSYDDWDYSLE------------ 341

  Fly   287 AYTQYRDRLGLLRTT------------------YNLNEEPQLSSAFYFDLALRSFLTIKEMLQSG 333
              .:.||.:|:|.|.                  |...|.|::           ...|:...:.:.
Human   342 --ARVRDGIGILTTAASSMLEKFSYIPEAKASCYGQMERPEV-----------PMHTLHPFMVNV 393

  Fly   334 AWP-KDMEYLNCDDFQGGNTPQRNLDLRDYFTKITEPTSYGTFDLVTQSTQPFNGHSFMKFEMDI 397
            .|. ||:.:                            |..|                   :::..
Human   394 TWDGKDLSF----------------------------TEEG-------------------YQVHP 411

  Fly   398 NVLQIRGGSSVNSKSIGKWISGLNSELIVKDE--EQMKNLT----ADTVYRIFTVVQAPFIMRDE 456
            .::.|........:.:|||   .|..|.::..  .:.|:.:    .|....|.|:.:|||::.::
Human   412 RLVVIVLNKDREWEKVGKW---ENHTLSLRHAVWPRYKSFSDCEPDDNHLSIVTLEEAPFVIVED 473

  Fly   457 TAP-----------------------------KGYKGYCIDLINEIAAIVHFDYTIQEVEDGKFG 492
            ..|                             |..||:|||::.:::..|.|.|.:..|.:||.|
Human   474 IDPLTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLVTNGKHG 538

  Fly   493 NMDENGQWNGIVKKLMDKQADIGLGSMSVMAEREIVIDFTVPYYDLVGITIMMQRPSSPSSLFKF 557
            . ..|..|||::.:::.::|.:.:||:::..||..|:||:||:.: .||::|:.|.:...|...|
Human   539 K-KVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVE-TGISVMVSRSNGTVSPSAF 601

  Fly   558 LTVLETNVWLCILAAYFFTSFL-MWIFDRWSPYSYQNNREKYKDDEEKREFNLKECLWFCM---- 617
            |.....:||:.:.......|.: :::|:.:||..|..|..|.|..... .|.:.:.:|...
Human   602 LEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPHGP-SFTIGKAIWLLWGLVF 665

  Fly   618 -TSLTPQGGGEAPKNLSGRLVAATWWLFGFIIIASYTANLAAFLTVSRLDTPVESLDDLAKQYKI 681
             .|:..|.    ||..:.:::.:.|..|..|.:||||||||||:........|..|.|...|...
Human   666 NNSVPVQN----PKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVDQVTGLSDKKFQRPH 726

  Fly   682 LYAP-------LNGSSAMTYFERMSNIEQMFYEIWKDLSLNDSLTAVERSKLAVWDYPVSDKY-T 738
            .|:|       .|||:     ||  ||..                          :||...:| |
Human   727 DYSPPFRFGTVPNGST-----ER--NIRN--------------------------NYPYMHQYMT 758

  Fly   739 KMWQAMQEAKLPATLDEAVARVRNSTAATG--FAFLGDATDIRYL--QLTNCDLQVVGEE--FSR 797
            |..|        ..:::|:..::     ||  .||:.||..:.|.  :...|.|..:|..  |:.
Human   759 KFNQ--------KGVEDALVSLK-----TGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFAT 810

  Fly   798 KPYAIAVQQGSHLKDQFNNAILTLLNKRQLEKLKEKWWKNDEALAKCDKPEDQSDGISIQNIGGV 862
            ..|.||:|:||..|.|.:.|:|..:...::|:|:..|.   ..:...:|.|..|..:.|.|:.||
Human   811 TGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWL---TGICHNEKNEVMSSQLDIDNMAGV 872

  Fly   863 FIVIFVGIGMACITLVFE---YWWYRYRKNPRIIDVAEANAERSNAADHPGKLVD---GVILGHS 921
            |.::...:.::.||.::|   ||..|:             ......:|.||.|..   |:.....
Human   873 FYMLAAAMALSLITFIWEHLFYWKLRF-------------CFTGVCSDRPGLLFSISRGIYSCIH 924

  Fly   922 GEKFEKSKAALRPRFN 937
            |...|:.|.:  |.||
Human   925 GVHIEEKKKS--PDFN 938

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	40..426	CDD:107378	63/417 (15%)
		PBP2_iGluR_putative	438..836	CDD:270435	114/446 (26%)
		Lig_chan	565..870	CDD:278489	81/324 (25%)
GRIN2A	XP_016878661.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156047
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740