DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ir25a and GRIN1

DIOPT Version :9

Sequence 1:NP_001260049.1 Gene:Ir25a / 33683 FlyBaseID:FBgn0031634 Length:947 Species:Drosophila melanogaster
Sequence 2:XP_005266130.1 Gene:GRIN1 / 2902 HGNCID:4584 Length:959 Species:Homo sapiens


Alignment Length:1050 Identity:234/1050 - (22%)
Similarity:410/1050 - (39%) Gaps:264/1050 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    18 LSLLSSFSLEIAAQTTQ--NINVLFINEVDNEPAAKAVEVVLTYLKKNIRYG-LSVQLDSIE-AN 78
            |:||.|.|:..||...:  ||..:.......:...:||.      :.|.|:| ..:||::.. .:
Human     9 LALLFSCSVARAACDPKIVNIGAVLSTRKHEQMFREAVN------QANKRHGSWKIQLNATSVTH 67

  Fly    79 KSDAKVLLEAICNK------YATSIEKKQTP--HLILDTTKSGIASETVKSFT------QALGLP 129
            |.:|..:..::|..      ||..:....||  |.          :.|..|:|      ..|||.
Human    68 KPNAIQMALSVCEDLISSQVYAILVSHPPTPNDHF----------TPTPVSYTAGFYRIPVLGLT 122

  Fly   130 TISASYGQQGDLRQWRDLDEAKQKYLLQVMPP----ADIIPEAIRSIVIHMNITNAAILYDDSFV 190
            |..:.|.           |::.....|:.:||    :.:..|.:|  |...|  :..:|..|   
Human   123 TRMSIYS-----------DKSIHLSFLRTVPPYSHQSSVWFEMMR--VYSWN--HIILLVSD--- 169

  Fly   191 MDHKYKSLLQNIQTRHVITAIAKDGKREREEQIEKLRNLDINN----------FFILGTLQSIRM 245
             ||:.::..:.::     |.:.:...:.::...|.|..|..:|          .|..||.....:
Human   170 -DHEGRAAQKRLE-----TLLEERESKSKKRNYENLDQLSYDNKRGPKAEKVLQFDPGTKNVTAL 228

  Fly   246 VLESVKPAYFERNFAWHAITQNEGE-----ISSQRDNATIMF----MKPMAYTQY---------- 291
            ::|:                 .|.|     :|:..|:|..::    |..|..:.|          
Human   229 LMEA-----------------KELEARVIILSASEDDAATVYRAAAMLNMTGSGYVWLVGEREIS 276

  Fly   292 -------RDRLGLLRTTYNLNEEPQLSSAFYFDLALRSFLTIKEMLQSGAWPKDMEYLNCDDFQG 349
                   .|.:..|:.....||...:|.|  ..:..::   :.|:|         |..|..|...
Human   277 GNALRYAPDGILGLQLINGKNESAHISDA--VGVVAQA---VHELL---------EKENITDPPR 327

  Fly   350 GNTPQRNL-DLRDYFTKITEPTSY-----GTFDLVTQSTQPFNGHSFMKFEMDINVLQ--IRGGS 406
            |.....|: .....|.::...:.|     |..:......:.|..:|.|..: :..::|  |..|:
Human   328 GCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQ-NRKLVQVGIYNGT 391

  Fly   407 SV--NSKSIGKWISGLNSELIVKDEEQMKNLTADTVYRIFTVVQAPFI----------MRDE--- 456
            .|  |.:.| .|..|        :.|:.:.....|..:|.|:.|.||:          .::|   
Human   392 HVIPNDRKI-IWPGG--------ETEKPRGYQMSTRLKIVTIHQEPFVYVKPTLSDGTCKEEFTV 447

  Fly   457 -----------------------TAPKGYKGYCIDLINEIAAIVHFDYTIQEVEDGKFG-----N 493
                                   |.|:...|:||||:.::|..::|.|.:..|.|||||     |
Human   448 NGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVADGKFGTQERVN 512

  Fly   494 MDENGQWNGIVKKLMDKQADIGLGSMSVMAEREIVIDFTVPY-YDLVGITIMMQRPSSPSSLFKF 557
            .....:|||::.:|:..|||:.:..:::..||...|:|:.|: |.  |:||::::....|:|..|
Human   513 NSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQ--GLTILVKKEIPRSTLDSF 575

  Fly   558 LTVLETNVWLCILAAYFFTSFLMWIFDRWSPYS-YQNNREKYKDDEEKREFNLKECLWFCMTSLT 621
            :...::.:||.:..:....:.::::.||:||:. ::.|.|    :||:....|...:||....|.
Human   576 MQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSE----EEEEDALTLSSAMWFSWGVLL 636

  Fly   622 PQGGGE-APKNLSGRLVAATWWLFGFIIIASYTANLAAFLTVSRLDTPVESLDDLAKQY---KIL 682
            ..|.|| ||::.|.|::...|..|..||:|||||||||||.:.|.:..:..::|...:.   |.:
Human   637 NSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDKFI 701

  Fly   683 YAPLNGSSAMTYFERMSNIEQMFYEIWKDLSLNDSLTAVERSKLAVWDYPVSDKYTKMWQAMQEA 747
            ||.:..||...||.|...:..|:..:.|. :...:..|:                    ||:::.
Human   702 YATVKQSSVDIYFRRQVELSTMYRHMEKH-NYESAAEAI--------------------QAVRDN 745

  Fly   748 KLPATLDEAVARVRNSTAATGFAFLGDATDIRYLQLTNCDLQVVGEEFSRKPYAIAVQQGSHLKD 812
            ||                   .||:.|:..:.:.....|||...||.|.|..:.|.:::.|..|.
Human   746 KL-------------------HAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQ 791

  Fly   813 QFNNAILTLLNKRQLEKLKEKWWKNDEALAKCDKPEDQSDGISIQNIGGVFIVIFVGIGMACITL 877
            ..:.:||.......:|.|.:.|.:..|    ||...:....::.:|:.|||:::..|| :|.|.|
Human   792 NVSLSILKSHENGFMEDLDKTWVRYQE----CDSRSNAPATLTFENMAGVFMLVAGGI-VAGIFL 851

  Fly   878 VFEYWWYRYRKNPR----IIDVAEANAERSNAADHPGKLVDGVILGHSG--EKFEKSKAALRPRF 936
            :|....|:..|:.|    .:..|..|..|.|..|.           .||  |...|.||..|...
Human   852 IFIEIAYKRHKDARRKQMQLAFAAVNVWRKNLQDR-----------KSGRAEPDPKKKATFRAIT 905

  Fly   937 NQYPATFKPR 946
            :...::||.|
Human   906 STLASSFKRR 915

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ir25aNP_001260049.1 PBP1_iGluR_AMPA_Like 40..426 CDD:107378 79/451 (18%)
PBP2_iGluR_putative 438..836 CDD:270435 114/444 (26%)
Lig_chan 565..870 CDD:278489 78/309 (25%)
GRIN1XP_005266130.1 PBP1_iGluR_NMDA_NR1 25..404 CDD:380602 80/451 (18%)
PBP2_iGluR_NMDA_Nr1 416..820 CDD:270437 115/453 (25%)
CaM_bdg_C0 856..884 CDD:402271 7/27 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000021
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.910

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