DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir25a and GRIK5

DIOPT Version :9

Sequence 1:	NP_001260049.1	Gene:	Ir25a / 33683	FlyBaseID:	FBgn0031634	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	XP_011525167.1	Gene:	GRIK5 / 2901	HGNCID:	4583	Length:	982	Species:	Homo sapiens

Alignment Length:	923	Identity:	233/923 - (25%)
Similarity:	402/923 - (43%)	Gaps:	182/923 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 INEVDNEPAAKAVEVVLTYLKKNIRYGLSVQLDSIEANKSDAKVLLEAICNKYATSIEKKQTPHL 105
            ||.:...||...|||.:..|:::.:|         |...:..::|.:.:.:
Human    51 INGIIEVPAKARVEVDIFELQRDSQY---------ETTDTMCQILPKGVVS-------------- 92

  Fly   106 ILDTTKSGIASETVKSFTQALGLPTISASYGQQGDLRQWRDLDEAKQKYL----LQVMPPADIIP 166
            :|..:.|..::.||........:|.|..  |.:         :..:.:||    :.:.|..:.:.
Human    93 VLGPSSSPASASTVSHICGEKEIPHIKV--GPE---------ETPRLQYLRFASVSLYPSNEDVS 146

  Fly   167 EAIRSIVIHMNITNAAILYDDSFVMDHKYKSLLQNIQTRHVITAIAKDGKREREEQIEKLRNLDI 231
            .|:..|:...|..:|:::...:..:....:.:...:.::..::....|..|:....::::|:..:
Human   147 LAVSRILKSFNYPSASLICAKAECLLRLEELVRGFLISKETLSVRMLDDSRDPTPLLKEIRDDKV 211

  Fly   232 NNFFILGTLQSIRMVLESVKPAYFERNFAWHAITQNEGEI----SSQRDNATIM--FMKPMAYTQ 290
            :...|........::|...........|..:.:|..:..|    ....|::.|:  .|...::..
Human   212 STIIIDANASISHLILRKASELGMTSAFYKYILTTMDFPILHLDGIVEDSSNILGFSMFNTSHPF 276

  Fly   291 YRDRLGLLRTTYNLNEE------PQLSSAFYFDLALRSFLTIKEMLQS-------------GAWP 336
            |.:.:..|..::..|.|      |.||:|..||........::|:.:|             ..||
Human   277 YPEFVRSLNMSWRENCEASTYLGPALSAALMFDAVHVVVSAVRELNRSQEIGVKPLACTSANIWP 341

  Fly   337 KD---MEYLNCDDFQGGNTPQRNLDLRDYFTKITEPTSYGTFDLVTQSTQPFNGHSFMKFEMDIN 398
            ..   |.||...::.|       |..|..|....:.|:| |..::.:|.|   ||
Human   342 HGTSLMNYLRMVEYDG-------LTGRVEFNSKGQRTNY-TLRILEKSRQ---GH---------- 385

  Fly   399 VLQIRGGSSVNSKSIGKWIS----GLNSELIVKDEEQMKNLTADTVYRIFTVVQAPFIMRDE--- 456
                        :.||.|.|    .:|:..:   :..:....|:....:.|:::.|::||..
Human   386 ------------REIGVWYSNRTLAMNATTL---DINLSQTLANKTLVVTTILENPYVMRRPNFQ 435

  Fly   457 --TAPKGYKGYCIDLINEIAAIVHFDYTIQEVEDGKFGNMDENGQWNGIVKKLMDKQ-ADIGLGS 518
              :..:.::|:|:|::.|:|.::.|.|.::.||||.:|..:.||.|.|:|.:|:::| ||:.:.:
Human   436 ALSGNERFEGFCVDMLRELAELLRFRYRLRLVEDGLYGAPEPNGSWTGMVGELINRQKADLAVAA 500

  Fly   519 MSVMAEREIVIDFTVPYYDLVGITI-----MMQRPSSPSSLFKFLTVLETNVWLCILAAYFFTSF 578
            .::.||||.||||:.|:..| ||:|     |.::|    ..|.||......|||.:|.||...|.
Human   501 FTITAEREKVIDFSKPFMTL-GISILYRVHMGRKP----GYFSFLDPFSPAVWLFMLLAYLAVSC 560

  Fly   579 LMWIFDRWSPYSYQNNRE--KYKDDEEKREFNLKECLWFCMTSLTPQGGGEAPKNLSGRLVAATW 641
            ::::..|.|||.:.|...  :.:....:.::.|...|||.:.....||....|:.||.|.|:..|
Human   561 VLFLAARLSPYEWYNPHPCLRARPHILENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVW 625

  Fly   642 WLFGFIIIASYTANLAAFLTVSRLDTPVESLDDLAKQYKILYAPLNGSSAMTYFERMSNIEQMFY 706
            |.|..|||:||||||||||||.|::.||||.||||.|..|.|..::..|.||:|:...      |
Human   626 WAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFFQNSR------Y 684

  Fly   707 EIWKDLSLNDSLTAVERSKLAVWDYPVSDKYTKMWQAMQEAKLPA----TLDEAVARVRNSTAAT 767
            :                            .|.:||..|| :|.|:    :.:|.:|||.||.
Human   685 Q----------------------------TYQRMWNYMQ-SKQPSVFVKSTEEGIARVLNSR--- 717

  Fly   768 GFAFLGDATDIRYLQLTNCDLQVVGEEFSRKPYAIAVQQGSHLKDQFNNAILTLLNKRQLEKLKE 832
             :|||.::|...|.:..||:|..:|.....|.|.|.:..||..:|:...|||.|....:||.||.
Human   718 -YAFLLESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKR 781

  Fly   833 KWWKNDEALAKCDKPED-QSDGISIQNIGGVFIVIFVGIGMACITLVFEYWWYRYRKNPRIIDVA 896
            |||:.    .:|.|.|| ::.|:.::||||:|||:..|:.:|....|.|:.|...|
Human   782 KWWEG----GRCPKEEDHRAKGLGMENIGGIFIVLICGLIIAVFVAVMEFIWSTRR--------- 833

  Fly   897 EANAERSNAADHP 909
            .|.:|.:.|. ||
Human   834 SAESEETPAL-HP 845

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	40..426	CDD:107378	69/420 (16%)
		PBP2_iGluR_putative	438..836	CDD:270435	139/414 (34%)
		Lig_chan	565..870	CDD:278489	109/311 (35%)
GRIK5	XP_011525167.1	PBP1_iGluR_Kainate_KA1_2	25..399	CDD:107389	68/414 (16%)
		ANF_receptor	42..379	CDD:279440	60/369 (16%)
		Periplasmic_Binding_Protein_Type_2	414..785	CDD:304360	139/414 (34%)
		Lig_chan	546..816	CDD:278489	109/312 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156282
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840