DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir25a and GRIK4

DIOPT Version :9

Sequence 1:	NP_001260049.1	Gene:	Ir25a / 33683	FlyBaseID:	FBgn0031634	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	NP_001269399.1	Gene:	GRIK4 / 2900	HGNCID:	4582	Length:	956	Species:	Homo sapiens

Alignment Length:	1006	Identity:	259/1006 - (25%)
Similarity:	431/1006 - (42%)	Gaps:	190/1006 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 PKTSKIL-----WLLGFLSLLSSFSLEIAAQTTQNINVLFINEVDNEP--AAKAVEVVLTYLKKN 63
            |:.|..|     ||:  :...|..||.|||             :.::|  .::...:.:|..|..
Human     2 PRVSAPLVLLPAWLV--MVACSPHSLRIAA-------------ILDDPMECSRGERLSITLAKNR 51

  Fly    64 I-----RYG-LSVQLDSIEANKSDAKVLLEAICNKYATSIEKKQTPHLILDTTKSGIASETVKSF 122
            |     |.| ..|::|..|..:.......|.:|......:.....|       .|..||.::
Human    52 INRAPERLGKAKVEVDIFELLRDSEYETAETMCQILPKGVVAVLGP-------SSSPASSSI--- 106

  Fly   123 TQALGLPTISASYGQQGDLRQWRDLDEAKQKYLLQVMPPADIIPE------AIRSIVIHMNITNA 181
                    ||...|:: ::..::...|...|:..|.....::.|.      |:..|:...|.|.|
Human   107 --------ISNICGEK-EVPHFKVAPEEFVKFQFQRFTTLNLHPSNTDISVAVAGILNFFNCTTA 162

  Fly   182 AILYDDSFVMDHKYKSLLQNIQTRHVITAIAKDGKREREEQIEKLRNLDINNFFILGTLQSIRMV 246
            .::...:..:.:..|.|.|.:.::..::....|..|:....::::|:.......|.........:
Human   163 CLICAKAECLLNLEKLLRQFLISKDTLSVRMLDDTRDPTPLLKEIRDDKTATIIIHANASMSHTI 227

  Fly   247 LESVKPAYFERNFAWHAITQNEGEISSQR------DNATIM----FMKPMAYTQYRDRLGLLRTT 301
            |  :|.|......|::.......|.|.||      |...|:    |.:..|:.|        ...
Human   228 L--LKAAELGMVSAYYTYIFTNLEFSLQRMDSLVDDRVNILGFSIFNQSHAFFQ--------EFA 282

  Fly   302 YNLNEE------------PQLSSAFYFDLALRSFLTIKEMLQS---GAWPKDMEYLNCDDFQGGN 351
            .:||:.            |.||||..||........::|:.:|   |..|     |:|...|
Human   283 QSLNQSWQENCDHVPFTGPALSSALLFDAVYAVVTAVQELNRSQEIGVKP-----LSCGSAQ--- 339

  Fly   352 TPQRNLDLRDYFTKITEPTSYGTFDLVTQSTQPFNGHSFMKFEMDINVLQI-RGGSSVNSKSIGK 415
            ..|....|.:|...:......|..:        ||... .:....:.:||. |.|    .:.||:
Human   340 IWQHGTSLMNYLRMVELEGLTGHIE--------FNSKG-QRSNYALKILQFTRNG----FRQIGQ 391

  Fly   416 W--ISGLNSELIVKDEEQMKNLTADTVYR----IFTVVQAPFIM-----RDETAPKGYKGYCIDL 469
            |  ..||:     .|.....:..:||::.    :.|:::.|::|     ::......|:|:|:|:
Human   392 WHVAEGLS-----MDSHLYASNISDTLFNTTLVVTTILENPYLMLKGNHQEMEGNDRYEGFCVDM 451

  Fly   470 INEIAAIVHFDYTIQEVEDGKFGNMDENGQWNGIVKKLMDKQADIGLGSMSVMAEREIVIDFTVP 534
            :.|:|.|:.|:|.|:.|.||.:|..:.||.|.|:|.:|:.::||:.:..:::.||||.||||:.|
Human   452 LKELAEILRFNYKIRLVGDGVYGVPEANGTWTGMVGELIARKADLAVAGLTITAEREKVIDFSKP 516

  Fly   535 YYDLVGITI-----MMQRPSSPSSLFKFLTVLETNVWLCILAAYFFTSFLMWIFDRWSPYSYQNN 594
            :..| ||:|     |.::|    ..|.||......|||.:|.||...|.::::..|.:||.:.:.
Human   517 FMTL-GISILYRVHMGRKP----GYFSFLDPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYSP 576

  Fly   595 R--EKYKDDEEKREFNLKECLWFCMTSLTPQGGGEAPKNLSGRLVAATWWLFGFIIIASYTANLA 657
            .  .:.:.:....:::|...|||.:.....||...||:.||.|.|:..||.|..|||:|||||||
Human   577 HPCAQGRCNLLVNQYSLGNSLWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLA 641

  Fly   658 AFLTVSRLDTPVESLDDLAKQYKILYAPLNGSSAMTYFERMSNIEQMFYEIWKDLSLNDSLTAVE 722
            |||||.|:|.|:||:||||.|..|.|..::|.|:||:|:   |.....|:
Human   642 AFLTVQRMDVPIESVDDLADQTAIEYGTIHGGSSMTFFQ---NSRYQTYQ--------------- 688

  Fly   723 RSKLAVWDYPVSDKYTKMWQAMQEAKLPATLDEAVARVRNSTAATGFAFLGDATDIRYLQLTNCD 787
                .:|:|    .|:|     |.:....:.:|.:|||.||    .:|||.::|...|.:..||:
Human   689 ----RMWNY----MYSK-----QPSVFVKSTEEGIARVLNS----NYAFLLESTMNEYYRQRNCN 736

  Fly   788 LQVVGEEFSRKPYAIAVQQGSHLKDQFNNAILTLLNKRQLEKLKEKWWKNDEALAKCDKPED-QS 851
            |..:|.....|.|.|.:..||..:|:|:.|||.|....:||.||.|||:.    .||.|.|| ::
Human   737 LTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQLQENNRLEILKRKWWEG----GKCPKEEDHRA 797

  Fly   852 DGISIQNIGGVFIVIFVGIGMACITLVFEY-WWYRYRKNPRIIDVAEANAERSNAADHPGKLVDG 915
            .|:.::||||:|:|:..|:.:|....:.|: |..|:.:...:....|...|           :..
Human   798 KGLGMENIGGIFVVLICGLIVAIFMAMLEFLWTLRHSEATEVSVCQEMVTE-----------LRS 851

  Fly   916 VILGHSGEKFEKSKAALRPRFNQYPATFKPR 946
            :||........:.:||:.|.....|...:||
Human   852 IILCQDSIHPRRRRAAVPPPRPPIPEERRPR 882

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	40..426	CDD:107378	78/427 (18%)
		PBP2_iGluR_putative	438..836	CDD:270435	141/413 (34%)
		Lig_chan	565..870	CDD:278489	109/307 (36%)
GRIK4	NP_001269399.1	PBP1_iGluR_Kainate_KA1_2	26..400	CDD:107389	81/441 (18%)
		ANF_receptor	43..382	CDD:279440	70/384 (18%)
		PBP2_iGluR_kainate_KA1	415..785	CDD:270442	139/409 (34%)
		Lig_chan	547..816	CDD:278489	109/307 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	863..889		6/20 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..956
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155784
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840