Protein Alignment Ir25a and GRIK3

DIOPT Version :10

• Sequence 1: NP_001260049.1
• Gene: Ir25a / 33683
• FlyBaseID: FBgn0031634
• Length: 947
• Species: Drosophila melanogaster
• Sequence 2: NP_000822.2
• Gene: GRIK3 / 2899
• HGNCID: 4581
• Length: 919
• Species: Homo sapiens
• Alignment Length: 922
• Identity: 247/922 - (26%)
• Similarity: 399/922 - (43%)
• Gaps: 207/922 - (22%)

  Fly    57 LTYLKKNIRYGLSVQLDSIEANKSDAKVLLEAICNKYATSIEKKQTPHLILDTTKSGIASETVKS 121
            |||..:.|.:.     ||.||.|.        .|::.|..:       :.:.....|..:..|:|
Human    79 LTYDIQRIHFH-----DSFEATKK--------ACDQLALGV-------VAIFGPSQGSCTNAVQS 123

  Fly   122 FTQALGLPTISASYGQQGDLRQWR--DLDEAKQKYLLQVMPPADIIPEAIRSIVIHMNITNAAIL 184
            ...||.:|.|..         :|:  .||. |..:.:.:.|....:..||..:|.::...:|.::
Human   124 ICNALEVPHIQL---------RWKHHPLDN-KDTFYVNLYPDYASLSHAILDLVQYLKWRSATVV 178

  Fly   185 YDDSFVMDHKYKSLLQNIQTRHVITAIAKDGKREREEQIEKLRNLDINNFFILGTLQSIRMVLES 249
            ||||..:          |:.:.:|.|.::...|      .|:|.|.|::       ...|.:|:.
Human   179 YDDSTGL----------IRLQELIMAPSRYNIR------LKIRQLPIDS-------DDSRPLLKE 220

  Fly   250 VKPAYFERNFAWHAITQNEGEISSQRDNATIMFMKPMAYTQYRDRLGLLRTT---YNLNEEPQLS 311
            :|     |...:..|......:::|      :..:.||.....:....:.||   |.|:.||..
Human   221 MK-----RGREFRIIFDCSHTMAAQ------ILKQAMAMGMMTEYYHFIFTTLDLYALDLEPYR- 273

  Fly   312 SAFYFDLALRSF--LTIKEMLQSGAWPK-DMEYLNCDDFQGGNTPQRNLDLRDYFTKITEPTSYG 373
               |..:.|..|  |.:.....|....| .||.|..       .|:....|.|..........|.
Human   274 ---YSGVNLTGFRILNVDNPHVSAIVEKWSMERLQA-------APRSESGLLDGVMMTDAALLYD 328

  Fly   374 TFDLVTQSTQ----------------------------------------PFNGHSFMKFEMDIN 398
            ...:|:...|                                        .||..|.::.:.|::
Human   329 AVHIVSVCYQRAPQMTVNSLQCHRHKAWRFGGRFMNFIKEAQWEGLTGRIVFNKTSGLRTDFDLD 393

  Fly   399 VLQIRGGSSVNSKSIGKW--ISGLNSELIVKDEEQMKNLTADTVYR---IFTVVQAPFIM---RD 455
            ::.::   ....:.:|.|  ..|||...:.|.  :..|:|.....|   :.||::.||:|   .|
Human   394 IISLK---EDGLEKVGVWSPADGLNITEVAKG--RGPNVTDSLTNRSLIVTTVLEEPFVMFRKSD 453

  Fly   456 ET--APKGYKGYCIDLINEIAAIVHFDYTIQEVEDGKFGNMDENGQWNGIVKKLMDKQADIGLGS 518
            .|  ....::||||||:.|:|.|:.|.|.|:.|||||:|..|:.|||||:||:|:|.:||:.:..
Human   454 RTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAP 518

  Fly   519 MSVMAEREIVIDFTVPYYDLVGITIMMQRPSSPS-SLFKFLTVLETNVWLCILAAYFFTSFLMWI 582
            :::...||..|||:.|:..| |::|:.::|:..: |:|.||..|..::|:.:|.||...|.::::
Human   519 LTITHVREKAIDFSKPFMTL-GVSILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFV 582

  Fly   583 FDRWSPYSYQNNREKYKDDE-EKREFNLKECLWFCMTSLTPQGGGEAPKNLSGRLVAATWWLFGF 646
            ..|:|||.:.:........| .:..|.|....||.|.||..||....||.||.|::...||.|..
Human   583 IARFSPYEWYDAHPCNPGSEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTL 647

  Fly   647 IIIASYTANLAAFLTVSRLDTPVESLDDLAKQYKILYAPLNGSSAMTYFERMSNIEQMFYEIWKD 711
            |||:||||||||||||.|:::|::|.||||||.||.|..:...:.||:|
Human   648 IIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFF---------------- 696

  Fly   712 LSLNDSLTAVERSKLAVWDYPVSDKYTKMWQAMQEAKLPATL----DEAVARVRNSTAATGFAFL 772
                      ::||::.::        |||..|  :..|:.|    :|.:.|    .....:|.|
Human   697 ----------KKSKISTFE--------KMWAFM--SSKPSALVKNNEEGIQR----ALTADYALL 737

  Fly   773 GDATDIRYLQLTNCDLQVVGEEFSRKPYAIAVQQGSHLKDQFNNAILTLLNKRQLEKLKEKWWKN 837
            .::|.|.|:...||:|..:|.....|.|.|....||..:|:...|||.|..:.:|..:|||||:.
Human   738 MESTTIEYVTQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWWRG 802

  Fly   838 DEALAKCDKPED-QSDGISIQNIGGVFIVIFVGIGMACITLVFEYWWYRYRKNPRIIDVAEANAE 901
                :.|.:.|: ::..:.||.|||:|||:..|:.::.:..|.|: .|:.||          .||
Human   803 ----SGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEF-VYKLRK----------TAE 852

  Fly   902 R------SNAAD 907
            |      |..||
Human   853 REQRSFCSTVAD 864

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	37..418	CDD:380606	74/410 (18%)
		PBP2_iGluR_putative	438..836	CDD:270435	144/411 (35%)
GRIK3	NP_000822.2	PBP1_iGluR_Kainate	37..417	CDD:380605	77/415 (19%)
		PBP2_iGluR_Kainate_GluR7	433..801	CDD:270441	144/408 (35%)