DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir25a and GRIK2

DIOPT Version :9

Sequence 1:NP_001260049.1 Gene:Ir25a / 33683 FlyBaseID:FBgn0031634 Length:947 Species:Drosophila melanogaster
Sequence 2:NP_068775.1 Gene:GRIK2 / 2898 HGNCID:4580 Length:908 Species:Homo sapiens


Alignment Length:979 Identity:251/979 - (25%)
Similarity:420/979 - (42%) Gaps:221/979 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 ILMNP---KTSK----ILWL---------LGFLSLLSSFSLEIAAQTTQNINVLFINEVDNEPAA 50
            ||.||   :|.|    :||:         |.|..:..  .:|......:.:...|.....|....
Human     7 ILSNPVFRRTVKLLLCLLWIGYSQGTTHVLRFGGIFE--YVESGPMGAEELAFRFAVNTINRNRT 69

  Fly    51 KAVEVVLTYLKKNIRYGLSVQLDSIEANKSDAKVLLEAICNKYATSIEKKQTPHLILDTTKSGIA 115
            ......|||..:.|..     .||.||:|.        .|::.:..:.      .|...:.|..|
Human    70 LLPNTTLTYDTQKINL-----YDSFEASKK--------ACDQLSLGVA------AIFGPSHSSSA 115

  Fly   116 SETVKSFTQALGLPTISASYGQQGDLRQWRDLDEAKQKYLLQVMPPADIIPEAIRSIVIHMNITN 180
            : .|:|...|||:|.|...:..|        :.:.|..:.:.:.|....:..||..:|.......
Human   116 N-AVQSICNALGVPHIQTRWKHQ--------VSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKT 171

  Fly   181 AAILYDDSFVMDHKYKSLLQNIQTRHVITAIAKDGKREREEQIEKLRNLDINNFFILGTLQSIRM 245
            ..::||||..:          |:.:.:|.|.::...|      .|:|.|..:.       :..:.
Human   172 VTVVYDDSTGL----------IRLQELIKAPSRYNLR------LKIRQLPADT-------KDAKP 213

  Fly   246 VLESVKPAYFERNFAWHAITQNEGEISSQRDNATIMFMKPMAYTQYRDRLGLLRTTYNLNEEPQL 310
            :|:.:|     |...:|.|      .....:.|..:..:.:|       :|::...|:       
Human   214 LLKEMK-----RGKEFHVI------FDCSHEMAAGILKQALA-------MGMMTEYYH------- 253

  Fly   311 SSAFYFDLALRSF-LTIKEMLQSGAWPKDMEYLNCDDFQGGN------------TPQRNLDLRDY 362
                |....|..| |.::....||........||.::.|..:            .|:.:..|.|.
Human   254 ----YIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDG 314

  Fly   363 FTKITEPTSYGTFDLVTQSTQPF----------NGHSFMKF------------------------ 393
            |........|....:|:.:.|.|          |.|...:|                        
Human   315 FMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLTGRITFNK 379

  Fly   394 ------EMDINVLQIRGGSSVNSKSIGKW--ISGLNSELIVKDEEQMKNLTADTVYR---IFTVV 447
                  :.|::|:.::   ....:.||.|  .||||  :....:.:..|:|.....|   :.|::
Human   380 TNGLRTDFDLDVISLK---EEGLEKIGTWDPASGLN--MTESQKGKPANITDSLSNRSLIVTTIL 439

  Fly   448 QAPFIMRDETAPKGY-----KGYCIDLINEIAAIVHFDYTIQEVEDGKFGNMDE-NGQWNGIVKK 506
            :.|:::..::....|     :||||||:.|::.|:.|.|.|:.|||||:|..|: ||||||:|::
Human   440 EEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDANGQWNGMVRE 504

  Fly   507 LMDKQADIGLGSMSVMAEREIVIDFTVPYYDLVGITIMMQRPSSPS-SLFKFLTVLETNVWLCIL 570
            |:|.:||:.:..:::...||.||||:.|:..| ||:|:.::|:..: .:|.||..|..::|:.||
Human   505 LIDHKADLAVAPLAITYVREKVIDFSKPFMTL-GISILYRKPNGTNPGVFSFLNPLSPDIWMYIL 568

  Fly   571 AAYFFTSFLMWIFDRWSPYSYQNNREKYKD-DEEKREFNLKECLWFCMTSLTPQGGGEAPKNLSG 634
            .||...|.::::..|:|||.:.|......| |..:..|.|....||.:.:|..||....||.||.
Human   569 LAYLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALST 633

  Fly   635 RLVAATWWLFGFIIIASYTANLAAFLTVSRLDTPVESLDDLAKQYKILYAPLNGSSAMTYFERMS 699
            |:|...||.|..|||:||||||||||||.|:::|::|.||||||.||.|..:...:.||:|    
Human   634 RIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFF---- 694

  Fly   700 NIEQMFYEIWKDLSLNDSLTAVERSKLAVWDYPVSDKYTKMWQAM---QEAKLPATLDEAVARVR 761
                                  ::||::.:|        |||..|   :::.|..:.:|.:.||.
Human   695 ----------------------KKSKISTYD--------KMWAFMSSRRQSVLVKSNEEGIQRVL 729

  Fly   762 NSTAATGFAFLGDATDIRYLQLTNCDLQVVGEEFSRKPYAIAVQQGSHLKDQFNNAILTLLNKRQ 826
            .|    .:|||.::|.|.::...||:|..:|.....|.|.:....||..:|:...|||.|..:.:
Human   730 TS----DYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGK 790

  Fly   827 LEKLKEKWWKNDEALAKCDKPEDQS---DGISIQNIGGVFIVIFVGIGMACITLVFEYWWYRYRK 888
            |..:|||||:.:..      ||::|   ..:.:|||||:|||:..|:.::....|.|: .|:.:|
Human   791 LHMMKEKWWRGNGC------PEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEF-LYKSKK 848

  Fly   889 NPRI 892
            |.::
Human   849 NAQL 852

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
Ir25aNP_001260049.1 PBP1_iGluR_AMPA_Like 40..426 CDD:107378 77/440 (18%)
PBP2_iGluR_putative 438..836 CDD:270435 143/411 (35%)
Lig_chan 565..870 CDD:278489 106/311 (34%)
GRIK2NP_068775.1 PBP1_iGluR_Kainate 37..414 CDD:380605 79/463 (17%)
Periplasmic_Binding_Protein_Type_2 430..800 CDD:419667 143/408 (35%)
Glutamate binding. /evidence=ECO:0000250|UniProtKB:P42260 516..518 0/1 (0%)