Protein Alignment Ir25a and GRIK2

DIOPT Version :10

• Sequence 1: NP_001260049.1
• Gene: Ir25a / 33683
• FlyBaseID: FBgn0031634
• Length: 947
• Species: Drosophila melanogaster
• Sequence 2: NP_068775.1
• Gene: GRIK2 / 2898
• HGNCID: 4580
• Length: 908
• Species: Homo sapiens
• Alignment Length: 979
• Identity: 251/979 - (25%)
• Similarity: 420/979 - (42%)
• Gaps: 221/979 - (22%)

  Fly     2 ILMNP---KTSK----ILWL---------LGFLSLLSSFSLEIAAQTTQNINVLFINEVDNEPAA 50
            ||.||   :|.|    :||:         |.|..:..  .:|......:.:...|.....|....
Human     7 ILSNPVFRRTVKLLLCLLWIGYSQGTTHVLRFGGIFE--YVESGPMGAEELAFRFAVNTINRNRT 69

  Fly    51 KAVEVVLTYLKKNIRYGLSVQLDSIEANKSDAKVLLEAICNKYATSIEKKQTPHLILDTTKSGIA 115
            ......|||..:.|..     .||.||:|.        .|::.:..:.      .|...:.|..|
Human    70 LLPNTTLTYDTQKINL-----YDSFEASKK--------ACDQLSLGVA------AIFGPSHSSSA 115

  Fly   116 SETVKSFTQALGLPTISASYGQQGDLRQWRDLDEAKQKYLLQVMPPADIIPEAIRSIVIHMNITN 180
            : .|:|...|||:|.|...:..|        :.:.|..:.:.:.|....:..||..:|.......
Human   116 N-AVQSICNALGVPHIQTRWKHQ--------VSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKT 171

  Fly   181 AAILYDDSFVMDHKYKSLLQNIQTRHVITAIAKDGKREREEQIEKLRNLDINNFFILGTLQSIRM 245
            ..::||||..:          |:.:.:|.|.::...|      .|:|.|..:.       :..:.
Human   172 VTVVYDDSTGL----------IRLQELIKAPSRYNLR------LKIRQLPADT-------KDAKP 213

  Fly   246 VLESVKPAYFERNFAWHAITQNEGEISSQRDNATIMFMKPMAYTQYRDRLGLLRTTYNLNEEPQL 310
            :|:.:|     |...:|.|      .....:.|..:..:.:|       :|::...|:
Human   214 LLKEMK-----RGKEFHVI------FDCSHEMAAGILKQALA-------MGMMTEYYH------- 253

  Fly   311 SSAFYFDLALRSF-LTIKEMLQSGAWPKDMEYLNCDDFQGGN------------TPQRNLDLRDY 362
                |....|..| |.::....||........||.::.|..:            .|:.:..|.|.
Human   254 ----YIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDG 314

  Fly   363 FTKITEPTSYGTFDLVTQSTQPF----------NGHSFMKF------------------------ 393
            |........|....:|:.:.|.|          |.|...:|
Human   315 FMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLTGRITFNK 379

  Fly   394 ------EMDINVLQIRGGSSVNSKSIGKW--ISGLNSELIVKDEEQMKNLTADTVYR---IFTVV 447
                  :.|::|:.::   ....:.||.|  .||||  :....:.:..|:|.....|   :.|::
Human   380 TNGLRTDFDLDVISLK---EEGLEKIGTWDPASGLN--MTESQKGKPANITDSLSNRSLIVTTIL 439

  Fly   448 QAPFIMRDETAPKGY-----KGYCIDLINEIAAIVHFDYTIQEVEDGKFGNMDE-NGQWNGIVKK 506
            :.|:::..::....|     :||||||:.|::.|:.|.|.|:.|||||:|..|: ||||||:|::
Human   440 EEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDANGQWNGMVRE 504

  Fly   507 LMDKQADIGLGSMSVMAEREIVIDFTVPYYDLVGITIMMQRPSSPS-SLFKFLTVLETNVWLCIL 570
            |:|.:||:.:..:::...||.||||:.|:..| ||:|:.::|:..: .:|.||..|..::|:.||
Human   505 LIDHKADLAVAPLAITYVREKVIDFSKPFMTL-GISILYRKPNGTNPGVFSFLNPLSPDIWMYIL 568

  Fly   571 AAYFFTSFLMWIFDRWSPYSYQNNREKYKD-DEEKREFNLKECLWFCMTSLTPQGGGEAPKNLSG 634
            .||...|.::::..|:|||.:.|......| |..:..|.|....||.:.:|..||....||.||.
Human   569 LAYLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALST 633

  Fly   635 RLVAATWWLFGFIIIASYTANLAAFLTVSRLDTPVESLDDLAKQYKILYAPLNGSSAMTYFERMS 699
            |:|...||.|..|||:||||||||||||.|:::|::|.||||||.||.|..:...:.||:|
Human   634 RIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFF---- 694

  Fly   700 NIEQMFYEIWKDLSLNDSLTAVERSKLAVWDYPVSDKYTKMWQAM---QEAKLPATLDEAVARVR 761
                                  ::||::.:|        |||..|   :::.|..:.:|.:.||.
Human   695 ----------------------KKSKISTYD--------KMWAFMSSRRQSVLVKSNEEGIQRVL 729

  Fly   762 NSTAATGFAFLGDATDIRYLQLTNCDLQVVGEEFSRKPYAIAVQQGSHLKDQFNNAILTLLNKRQ 826
            .|    .:|||.::|.|.::...||:|..:|.....|.|.:....||..:|:...|||.|..:.:
Human   730 TS----DYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGK 790

  Fly   827 LEKLKEKWWKNDEALAKCDKPEDQS---DGISIQNIGGVFIVIFVGIGMACITLVFEYWWYRYRK 888
            |..:|||||:.:..      ||::|   ..:.:|||||:|||:..|:.::....|.|: .|:.:|
Human   791 LHMMKEKWWRGNGC------PEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEF-LYKSKK 848

  Fly   889 NPRI 892
            |.::
Human   849 NAQL 852

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	37..418	CDD:380606	73/435 (17%)
		PBP2_iGluR_putative	438..836	CDD:270435	143/411 (35%)
GRIK2	NP_068775.1	PBP1_iGluR_Kainate	37..414	CDD:380605	79/463 (17%)
		Periplasmic_Binding_Protein_Type_2	430..800	CDD:473866	143/408 (35%)