DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir25a and GRIK1

DIOPT Version :9

Sequence 1:NP_001260049.1 Gene:Ir25a / 33683 FlyBaseID:FBgn0031634 Length:947 Species:Drosophila melanogaster
Sequence 2:NP_001317923.1 Gene:GRIK1 / 2897 HGNCID:4579 Length:949 Species:Homo sapiens


Alignment Length:984 Identity:260/984 - (26%)
Similarity:420/984 - (42%) Gaps:237/984 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 LW-------LLGFLSLLSSFSLEIAAQTTQNINVLFINEVDNEPA---AKAVEVVLTYLKKN--- 63
            ||       ||.||    .:.|...|.....|..:| ..|:|||.   ..|.:..:|.:.:|   
Human    12 LWTRDTSWALLYFL----CYILPQTAPQVLRIGGIF-ETVENEPVNVEELAFKFAVTSINRNRTL 71

  Fly    64 -----IRYGLS-VQL-DSIEANKSDAKVLLEAICNKYATSIEKKQTPHLILDTTKSGIASETVKS 121
                 :.|.:. :.| ||.||::        ..|::.|..:.....|     :..|.:::  |:|
Human    72 MPNTTLTYDIQRINLFDSFEASR--------RACDQLALGVAALFGP-----SHSSSVSA--VQS 121

  Fly   122 FTQALGLPTISASYGQQGDLRQWR--DLDEAKQKYLLQVMPPADIIPEAIRSIVIHMNITNAAIL 184
            ...||.:|.|..         :|:  .:|. |..:.:.:.|....|..||..:|::.|.....::
Human   122 ICNALEVPHIQT---------RWKHPSVDN-KDLFYINLYPDYAAISRAILDLVLYYNWKTVTVV 176

  Fly   185 YDDSFVMDHKYKSLLQNIQTRHVITAIAKDGKREREEQIEKLRNLDINNFFILGTLQSIRMVLES 249
            |:||..:          |:.:.:|.|.::...:      .|:|.|...|       :..:.:|:.
Human   177 YEDSTGL----------IRLQELIKAPSRYNIK------IKIRQLPSGN-------KDAKPLLKE 218

  Fly   250 VKPAYFERNFAWHAITQNEGEISSQRDNATIMFMKPMA-YTQYRDRLGLLRTTYNLNEEPQLSSA 313
            :|... |....:....:...||..|     |:||..|. |..|      ..||.:|         
Human   219 MKKGK-EFYVIFDCSHETAAEILKQ-----ILFMGMMTEYYHY------FFTTLDL--------- 262

  Fly   314 FYFDLALRSFLTIKEMLQSGAWPKDMEYLNCDD--------------FQGGNTPQRNLDLRDYFT 364
            |..||.|..:        ||........||.|:              .|....|:..| |....|
Human   263 FALDLELYRY--------SGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGL-LDGMMT 318

  Fly   365 KITEP------------TSYGTFDLVTQSTQ-----PF------------------NGH-SFMK- 392
              ||.            .|:....|...|.|     |:                  .|| :|.| 
Human   319 --TEAALMYDAVYMVAIASHRASQLTVSSLQCHRHKPWRLGPRFMNLIKEARWDGLTGHITFNKT 381

  Fly   393 ------FEMDINVLQIRGGSSVNS----------KSIGKWISGLNSELIVKDEEQMKNLT---AD 438
                  |::||..|:..|......          |.||.|.|.....:...::::..|:|   |:
Human   382 NGLRKDFDLDIISLKEEGTEKAAGEVSKHLYKVWKKIGIWNSNSGLNMTDSNKDKSSNITDSLAN 446

  Fly   439 TVYRIFTVVQAPFIM-RDETAP----KGYKGYCIDLINEIAAIVHFDYTIQEVEDGKFGNMDENG 498
            ....:.|:::.|::| |....|    ..::|||:||:.|::.|:.|.|.::.|.|||:|..::.|
Human   447 RTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFIYDVKLVPDGKYGAQNDKG 511

  Fly   499 QWNGIVKKLMDKQADIGLGSMSVMAEREIVIDFTVPYYDLVGITIMMQRPSSPS-SLFKFLTVLE 562
            :|||:||:|:|.:||:.:..:::...||.||||:.|:..| ||:|:.::|:..: .:|.||..|.
Human   512 EWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTL-GISILYRKPNGTNPGVFSFLNPLS 575

  Fly   563 TNVWLCILAAYFFTSFLMWIFDRWSPYSYQNNREKYKD-DEEKREFNLKECLWFCMTSLTPQGGG 626
            .::|:.:|.|....|.::::..|::||.:.|......| |..:..|.|....||.:.:|..||..
Human   576 PDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSE 640

  Fly   627 EAPKNLSGRLVAATWWLFGFIIIASYTANLAAFLTVSRLDTPVESLDDLAKQYKILYAPLNGSSA 691
            ..||.||.|:|...||.|..|||:||||||||||||.|:::|::|.||||||.||.|..:...|.
Human   641 LMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVRDGST 705

  Fly   692 MTYFERMSNIEQMFYEIWKDLSLNDSLTAVERSKLAVWDYPVSDKYTKMWQAM---QEAKLPATL 753
            ||:|                          ::||::.        |.|||..|   |:..|....
Human   706 MTFF--------------------------KKSKIST--------YEKMWAFMSSRQQTALVRNS 736

  Fly   754 DEAVARVRNSTAATGFAFLGDATDIRYLQLTNCDLQVVGEEFSRKPYAIAVQQGSHLKDQFNNAI 818
            ||.:.||    ..|.:|.|.::|.|.|:...||:|..:|.....|.|.:....||..:|:...||
Human   737 DEGIQRV----LTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAI 797

  Fly   819 LTLLNKRQLEKLKEKWWKNDEALAKCDKPED---QSDGISIQNIGGVFIVIFVGIGMACITLVFE 880
            |.|..:.:|..:|||||:.:..      ||:   ::..:.::||||:|||:..|:.::....:.|
Human   798 LQLQEEGKLHMMKEKWWRGNGC------PEEDNKEASALGVENIGGIFIVLAAGLVLSVFVAIGE 856

  Fly   881 YWWYRYRKN 889
            : .|:.|||
Human   857 F-IYKSRKN 864

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
Ir25aNP_001260049.1 PBP1_iGluR_AMPA_Like 40..426 CDD:107378 93/468 (20%)
PBP2_iGluR_putative 438..836 CDD:270435 139/407 (34%)
Lig_chan 565..870 CDD:278489 104/311 (33%)
GRIK1NP_001317923.1 Periplasmic_Binding_Protein_Type_1 35..430 CDD:324556 94/475 (20%)
Periplasmic_Binding_Protein_Type_2 446..815 CDD:328725 139/407 (34%)
Glutamate binding. /evidence=ECO:0000250 531..533 0/1 (0%)