DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir25a and GRID2

DIOPT Version :9

Sequence 1:	NP_001260049.1	Gene:	Ir25a / 33683	FlyBaseID:	FBgn0031634	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	XP_011530195.2	Gene:	GRID2 / 2895	HGNCID:	4576	Length:	1035	Species:	Homo sapiens

Alignment Length:	920	Identity:	209/920 - (22%)
Similarity:	382/920 - (41%)	Gaps:	194/920 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 TKSGIASETVKSFTQALGLPTISASYGQQGDLRQWRDLDEAKQK--YLLQVMPPADIIPEAIRSI 172
            |.:|    :::|...|:.:|.:.......|..|....|..:.:.  |.|.|.||. .:.:.|..:
Human   112 TSAG----SLQSLADAMHIPHLFIQRSTAGTPRSGCGLTRSNRNDDYTLSVRPPV-YLHDVILRV 171

  Fly   173 VIHMNITNAAILYDDSFVMDHKYKSLLQNIQTRHVITAIAKDGKREREEQIEKLRNLDINNFFIL 237
            |.........|.||..:.        ::.||  ..:..:::.|.....:::|...|..|...|..
Human   172 VTEYAWQKFIIFYDSEYD--------IRGIQ--EFLDKVSQQGMDVALQKVENNINKMITTLFDT 226

  Fly   238 GTLQSIRMVLESVKPAYFERNFA--------------------WHAITQNEGEISSQRDNATIMF 282
            ..::.:....::::.|....|.|                    |..|.:...::..|.     :.
Human   227 MRIEELNRYRDTLRRAILVMNPATAKSFITEVVETNLVAFDCHWIIINEEINDVDVQE-----LV 286

  Fly   283 MKPMAYTQYRDRLGLLRTTY----NLNE-----------------EP-----QLSSAFYFDLALR 321
            .:.:.      ||.::|.|:    |:::                 :|     ::|:.:.:|..|.
Human   287 RRSIG------RLTIIRQTFPVPQNISQRCFRGNHRISSTLCDPKDPFAQNMEISNLYIYDTVLL 345

  Fly   322 SFLTIKEMLQSGAWPKDMEYLNC-----DDFQGGNTPQRNLDLRDYFTKITEPTSYGT------- 374
            ......:.|:...| ..|..|:|     ..:|||.:....:. :...:.:|....:|.
Human   346 LANAFHKKLEDRKW-HSMASLSCIRKNSKPWQGGRSMLETIK-KGGVSGLTGELEFGENGGNPNV 408

  Fly   375 -FDLVTQSTQPFNGHSFMKFEMDINVLQIRGGSSVNSKSIGKW--ISGLNSELIVKDEEQMKNLT 436
             |:::..:.....|....|.|.    ::.:|.:......:|.|  ::|||..|   .:::::|..
Human   409 HFEILGTNYGEELGRGVRKNER----IRPQGSTGKIWPQLGCWNPVTGLNGSL---TDKKLENNM 466

  Fly   437 ADTVYRIFTVVQAPFIMRDETA---PKGYKGYCIDLINEIAAIVHFDYTIQEVEDGKFGNMDENG 498
            ...|.|:.||::.||:|..|..   ||.|:|:.||:::.::..:.|:|.|....|.|:|:..|:|
Human   467 RGVVLRVVTVLEEPFVMVSENVLGKPKKYQGFSIDVLDALSNYLGFNYEIYVAPDHKYGSPQEDG 531

  Fly   499 QWNGIVKKLMDKQADIGLGSMSVMAEREIVIDFTVPYYDLVGITIMMQRPSSPSSLFKFLTVLET 563
            .|||:|.:|:.|:||||:.::::..:||.|:|||..|.| ..:.::::|......:|..|...:.
Human   532 TWNGLVGELVFKRADIGISALTITPDRENVVDFTTRYMD-YSVGVLLRRAEKTVDMFACLAPFDL 595

  Fly   564 NVWLCILAAYFFTSFLMWIFDRWSPYSYQNNREKYKDDEEKREFNLKECLWFCMTSLTPQGGGEA 628
            ::|.||.........|:::.:..:|...|..        ......|...:||...|...|||...
Human   596 SLWACIAGTVLLVGLLVYLLNWLNPPRLQMG--------SMTSTTLYNSMWFVYGSFVQQGGEVP 652

  Fly   629 PKNLSGRLVAATWWLFGFIIIASYTANLAAFLTVSRLDTPVESLDDLAKQYKILYAPLNGSSAMT 693
            ...|:.|::...||||..|:|:|||||||||||::|:::.::||.||:||.:|.|..:..|:...
Human   653 YTTLATRMMMGAWWLFALIVISSYTANLAAFLTITRIESSIQSLQDLSKQTEIPYGTVLDSAVYE 717

  Fly   694 Y--------FERMSNIEQMFYEIWKDLS-LNDSLTAVERSKLAVWDYPVSDKYTKMWQAMQEAKL 749
            :        |||    :.|:.::|:.:: .|.|...|..|:..:                |:.|.
Human   718 HVRMKGLNPFER----DSMYSQMWRMINRSNGSENNVLESQAGI----------------QKVKY 762

  Fly   750 PATLDEAVARVRNSTAATGFAFLGDATDIRYLQLT--NCDLQVVGEEFSRKPYAIAVQQGSHLKD 812
                             ..:||:.||..:.|:.:.  :|....:|...:.:.|.||:|.||..:|
Human   763 -----------------GNYAFVWDAAVLEYVAINDPDCSFYTIGNTVADRGYGIALQHGSPYRD 810

  Fly   813 QFNNAILTLLNKRQLEKLKEKWW-KNDEALAKCD-----KPEDQSDGISIQNIGGVFIVIFVGIG 871
            .|:..||.|.....::.||.||| ||    .:||     ..:.:...:.|::..|||.::..||.
Human   811 VFSQRILELQQNGDMDILKHKWWPKN----GQCDLYSSVDTKQKGGALDIKSFAGVFCILAAGIV 871

  Fly   872 MACITLVFEYWWYRYRKNPRI--------IDVAEANAERSNAA----DHPGKLVDGVILGHSGEK 924
            ::|...:.|.||.: ||..|:        ||:...: .|.|:.    |.|.|            :
Human   872 LSCFIAMLETWWNK-RKGSRVPSKEDDKEIDLEHLH-RRVNSLCTDDDSPHK------------Q 922

  Fly   925 FEKSKAALRP 934
            |..|...|.|
Human   923 FSTSSIDLTP 932

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	40..426	CDD:107378	61/378 (16%)
		PBP2_iGluR_putative	438..836	CDD:270435	119/412 (29%)
		Lig_chan	565..870	CDD:278489	84/321 (26%)
GRID2	XP_011530195.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156082
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6275
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.690