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Protein Alignment Ir25a and GRIA4

DIOPT Version :9

Sequence 1:	NP_001260049.1	Gene:	Ir25a / 33683	FlyBaseID:	FBgn0031634	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	NP_000820.4	Gene:	GRIA4 / 2893	HGNCID:	4574	Length:	902	Species:	Homo sapiens

Alignment Length:	973	Identity:	272/973 - (27%)
Similarity:	438/973 - (45%)	Gaps:	200/973 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 ILWLLGFLSLLSSFSLEIAAQTTQNINVLFINEVDNEPAAKAVEVVLTYLKKNIR---YGLSVQL 72
            :|...||..|...     |..::..|..|||...|.|..|..:.:.|.....|..   :.|...:
Human     9 VLLFSGFWGLAMG-----AFPSSVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNASEAPFNLVPHV 68

  Fly    73 DSIEANKSDAKVLLEAICNKYATSI------EKKQTPHLILDTTKSGIASETVKSFTQALGLPTI 131
            |:||...|.|  :..|.|::|:..:      ..|::.|             |:.||..||.:..|
Human    69 DNIETANSFA--VTNAFCSQYSRGVFAIFGLYDKRSVH-------------TLTSFCSALHISLI 118

  Fly   132 SASYGQQGDLRQWRDLDEAKQKYLLQVMPPADIIPEAIRSIVIHMNITNAAILYDDSFVMDHKYK 196
            :.|:..:|:           .:::||:.|.   :..|:.|::.|........|||    .|..|
Human   119 TPSFPTEGE-----------SQFVLQLRPS---LRGALLSLLDHYEWNCFVFLYD----TDRGY- 164

  Fly   197 SLLQNIQTR------HVITAIAKDG--------------KREREE-----QIEKLRNLDINNFFI 236
            |:||.|..:      || :||..:.              :|:.::     :||:|:|:
Human   165 SILQAIMEKAGQNGWHV-SAICVENFNDVSYRQLLEELDRRQEKKFVIDCEIERLQNI------- 221

  Fly   237 LGTLQSIRMVLESVKPAYFERNFAWHAITQNEG--EISSQR-----DNAT----IMFMKPMAYTQ 290
               |:.|..|.:.||        .:|.|..|.|  :||.:|     .|.|    :.|..||. .:
Human   222 ---LEQIVSVGKHVK--------GYHYIIANLGFKDISLERFIHGGANVTGFQLVDFNTPMV-IK 274

  Fly   291 YRDRLGLL-RTTYNLNE-EPQLSSAFYFDLALRSFLTIKEMLQSGAWPKDMEYLNCDDFQGGNTP 353
            ..||...| :..|..:| .|:.:||..:|    ..|.:.|..:|      :.....|..:.||..
Human   275 LMDRWKKLDQREYPGSETPPKYTSALTYD----GVLVMAETFRS------LRRQKIDISRRGNAG 329

  Fly   354 Q----------RNLDLRDYF--TKITEPTSYGTFDLVTQSTQPFNGHSFMKFEMDINVLQIRGGS 406
            .          :.:|:....  .:|...|....||           |...:....::|.:::
Human   330 DCLANPAAPWGQGIDMERTLKQVRIQGLTGNVQFD-----------HYGRRVNYTMDVFELK--- 380

  Fly   407 SVNSKSIGKWISGLNSELIVKDEEQMKNLTADTVYR---IFTVVQAPFIM--RDETAPKG---YK 463
            |...:.:|.| :.::..::::|...:.|.||....|   :.|::::|::|  ::....:|   |:
Human   381 STGPRKVGYW-NDMDKLVLIQDVPTLGNDTAAIENRTVVVTTIMESPYVMYKKNHEMFEGNDKYE 444

  Fly   464 GYCIDLINEIAAIVHFDYTIQEVEDGKFGNMDENGQ-WNGIVKKLMDKQADIGLGSMSVMAEREI 527
            |||:||.:|||..:...|.|..|.|||:|..|.:.: |||:|.:|:..:|:|.:..:::...||.
Human   445 GYCVDLASEIAKHIGIKYKIAIVPDGKYGARDADTKIWNGMVGELVYGKAEIAIAPLTITLVREE 509

  Fly   528 VIDFTVPYYDLVGITIMMQRP-SSPSSLFKFLTVLETNVWLCILAAYFFTSFLMWIFDRWSPYSY 591
            ||||:.|:..| ||:||:::| .|...:|.||..|...:|:||:.||...|.::::..|:|||.:
Human   510 VIDFSKPFMSL-GISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEW 573

  Fly   592 QNNR-EKYKD---DEEKREFNLKECLWFCMTSLTPQGGGEAPKNLSGRLVAATWWLFGFIIIASY 652
            .... |..|:   |:...||.:...|||.:.:...||...:|::||||:|...||.|..|||:||
Human   574 HTEEPEDGKEGPSDQPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSY 638

  Fly   653 TANLAAFLTVSRLDTPVESLDDLAKQYKILYAPLNGSSAMTYFERMSNIEQMFYEIWKDLSLNDS 717
            ||||||||||.|:.:|:||.:|||||.:|.|..|:..|...:|
Human   639 TANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFF---------------------- 681

  Fly   718 LTAVERSKLAVWDYPVSDKYTKMWQAMQEAK---LPATLDEAVARVRNSTAATGFAFLGDATDIR 779
                .|||:||        |.|||..|:.|:   ...|..|.|||||.|...  ||||.::|...
Human   682 ----RRSKIAV--------YEKMWTYMRSAEPSVFTRTTAEGVARVRKSKGK--FAFLLESTMNE 732

  Fly   780 YL-QLTNCDLQVVGEEFSRKPYAIAVQQGSHLKDQFNNAILTLLNKRQLEKLKEKWW-KNDEALA 842
            |: |...||...||.....|.|.:|..:||.|:...|.|:|.|.....|:|||.||| ...|...
Human   733 YIEQRKPCDTMKVGGNLDSKGYGVATPKGSSLRTPVNLAVLKLSEAGVLDKLKNKWWYDKGECGP 797

  Fly   843 KCDKPEDQSDGISIQNIGGVFIVIFVGIGMACITLVFEYWWYRYRKNPRIIDVAEANAERSNA 905
            |....:|::..:|:.|:.|||.::..|:|:|.:..:.|: .|:.|...:.:.:..:.|.|:.|
Human   798 KDSGSKDKTSALSLSNVAGVFYILVGGLGLAMLVALIEF-CYKSRAEAKRMKLTFSEAIRNKA 859

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.