DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir25a and GRIA3

DIOPT Version :9

Sequence 1:NP_001260049.1 Gene:Ir25a / 33683 FlyBaseID:FBgn0031634 Length:947 Species:Drosophila melanogaster
Sequence 2:NP_000819.4 Gene:GRIA3 / 2892 HGNCID:4573 Length:894 Species:Homo sapiens


Alignment Length:976 Identity:257/976 - (26%)
Similarity:427/976 - (43%) Gaps:213/976 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    33 TQNINVLFINEVDNEPAAKAVEVVLTYLKKNIR---YGLSVQLDSIEANKSDAKVLLEAICNKYA 94
            |.:|..||:.....|.:|....|.|....:|..   :.|:..:|.::::.|.:  :..|.|::::
Human    33 TISIGGLFMRNTVQEHSAFRFAVQLYNTNQNTTEKPFHLNYHVDHLDSSNSFS--VTNAFCSQFS 95

  Fly    95 TSIEKKQTPHLILDTTKSGIASETVKSFTQALGLPTISASYGQQGDLRQWRDLDEAKQKYLLQVM 159
            ..:      :.|...... ::..|:.||..||....::.|:....|:           ::::|:.
Human    96 RGV------YAIFGFYDQ-MSMNTLTSFCGALHTSFVTPSFPTDADV-----------QFVIQMR 142

  Fly   160 PPADIIPEAIRSIVIHMNITNAAILYDDSFVMDHKYKSLLQNI-----QTRHVITA--------- 210
            |   .:..||.|::.|........|||     ..:..|:||.|     |....:||         
Human   143 P---ALKGAILSLLGHYKWEKFVYLYD-----TERGFSILQAIMEAAVQNNWQVTARSVGNIKDV 199

  Fly   211 -----IAKDGKREREE------QIEKLRNLDINNFFILG-----------TLQSIRMVLESVKPA 253
                 |.::..|.:|:      ::|:: |..:....|||           .|....::||.|  .
Human   200 QEFRRIIEEMDRRQEKRYLIDCEVERI-NTILEQVVILGKHSRGYHYMLANLGFTDILLERV--M 261

  Fly   254 YFERNFAWHAITQNEGEISSQ---------------RDNATIMFMKPMAYTQYRDRLGLLRTTYN 303
            :...|.....|..||..:..|               ..||      |:.||.......:|     
Human   262 HGGANITGFQIVNNENPMVQQFIQRWVRLDEREFPEAKNA------PLKYTSALTHDAIL----- 315

  Fly   304 LNEEPQLSSAFYF------DLALRSFLTIKEMLQSGAWPKDMEYLNCDDFQGGNTPQRNLDLRDY 362
                 .::.||.:      |::.|.  :..:.|.:.|.|          :..|...:|.|.:   
Human   316 -----VIAEAFRYLRRQRVDVSRRG--SAGDCLANPAVP----------WSQGIDIERALKM--- 360

  Fly   363 FTKITEPTSYGTFDLVTQSTQPFNGHSFMKFEMDINVLQIRGGSSVNSKSIGKWISGLNSELIVK 427
             .::...|....||...:.|         .:.:|:..:::.|     |:..|.|  ......:..
Human   361 -VQVQGMTGNIQFDTYGRRT---------NYTIDVYEMKVSG-----SRKAGYW--NEYERFVPF 408

  Fly   428 DEEQMKNLTADTVYR---IFTVVQAPFIM--RDETAPKG---YKGYCIDLINEIAAIVHFDYTIQ 484
            .::|:.|.:|.:..|   :.|::::|::|  ::....:|   |:|||:||..|||..|...|.:.
Human   409 SDQQISNDSASSENRTIVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLS 473

  Fly   485 EVEDGKFGNMD-ENGQWNGIVKKLMDKQADIGLGSMSVMAEREIVIDFTVPYYDLVGITIMMQRP 548
            .|.|||:|..| |...|||:|.:|:..:|||.:..:::...||.||||:.|:..| ||:||:::|
Human   474 IVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSL-GISIMIKKP 537

  Fly   549 -SSPSSLFKFLTVLETNVWLCILAAYFFTSFLMWIFDRWSPYSY--QNNREKYKDDEE----KRE 606
             .|...:|.||..|...:|:||:.||...|.::::..|:|||.:  ::|.|:.:|.:.    ..|
Human   538 QKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQSPPDPPNE 602

  Fly   607 FNLKECLWFCMTSLTPQGGGEAPKNLSGRLVAATWWLFGFIIIASYTANLAAFLTVSRLDTPVES 671
            |.:...|||.:.:...||...:|::||||:|...||.|..|||:||||||||||||.|:.:|:||
Human   603 FGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIES 667

  Fly   672 LDDLAKQYKILYAPLNGSSAMTYFERMSNIEQMFYEIWKDLSLNDSLTAVERSKLAVWDYPVSDK 736
            .:|||||.:|.|..|:..|...:|                          .|||:||        
Human   668 AEDLAKQTEIAYGTLDSGSTKEFF--------------------------RRSKIAV-------- 698

  Fly   737 YTKMWQAMQEAK---LPATLDEAVARVRNSTAATGFAFLGDATDIRYL-QLTNCDLQVVGEEFSR 797
            |.|||..|:.|:   ...|..:.|||||.|...  ||||.::|...|: |...||...||.....
Human   699 YEKMWSYMKSAEPSVFTKTTADGVARVRKSKGK--FAFLLESTMNEYIEQRKPCDTMKVGGNLDS 761

  Fly   798 KPYAIAVQQGSHLKDQFNNAILTLLNKRQLEKLKEKWWKNDEALAKCDK----PEDQSDGISIQN 858
            |.|.:|..:||.|::..|.|:|.|..:..|:|||.|||.:.   .:|..    .:|::..:|:.|
Human   762 KGYGVATPKGSALRNAVNLAVLKLNEQGLLDKLKNKWWYDK---GECGSGGGDSKDKTSALSLSN 823

  Fly   859 IGGVFIVIFVGIGMACITLVFEYWWYRYR---------KNPRIIDVAEANAERSNAADHPGKLVD 914
            :.|||.::..|:|:|.:..:.|: .|:.|         ||.:....|.|...::.|....|..|.
Human   824 VAGVFYILVGGLGLAMMVALIEF-CYKSRAESKRMKLTKNTQNFKPAPATNTQNYATYREGYNVY 887

  Fly   915 G 915
            |
Human   888 G 888

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
Ir25aNP_001260049.1 PBP1_iGluR_AMPA_Like 40..426 CDD:107378 77/445 (17%)
PBP2_iGluR_putative 438..836 CDD:270435 152/417 (36%)
Lig_chan 565..870 CDD:278489 111/318 (35%)
GRIA3NP_000819.4 PBP1_iGluR_AMPA_GluR3 35..409 CDD:380610 79/452 (17%)
PBP2_iGluR_AMPA 422..805 CDD:270433 153/422 (36%)
Glutamate binding. /evidence=ECO:0000250 508..510 0/1 (0%)