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Protein Alignment Ir25a and GRIA2

DIOPT Version :9

Sequence 1:	NP_001260049.1	Gene:	Ir25a / 33683	FlyBaseID:	FBgn0031634	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	NP_000817.5	Gene:	GRIA2 / 2891	HGNCID:	4572	Length:	883	Species:	Homo sapiens

Alignment Length:	1009	Identity:	265/1009 - (26%)
Similarity:	428/1009 - (42%)	Gaps:	267/1009 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ILMNPKTSKILWLLGFLSLLSSFSLEIAAQTTQNINVLFINEVDNEPAAKAVEVVLTYLKKNIRY 66
            :|::|    :||  |.:..:||.|::|..        ||....|.|.:|..|.:|..   ....:
Human     9 VLLSP----VLW--GLIFGVSSNSIQIGG--------LFPRGADQEYSAFRVGMVQF---STSEF 56

  Fly    67 GLSVQLDSIEANKSDAKVLLEAICNKYATSI-------EKKQTPHLILDTTKSGIASETVKSFTQ 124
            .|:..:|::|...|.|  :..|.|::::..:       :||..              .|:.||..
Human    57 RLTPHIDNLEVANSFA--VTNAFCSQFSRGVYAIFGFYDKKSV--------------NTITSFCG 105

  Fly   125 ALGLPTISASYGQQGDLRQWRDLDEAKQKYLLQVMPPADIIPEAIRSIVIHMNITNAAILYD--- 186
            .|.:..|:.|:...|           ...:::|:.|.   :..|:.|::.:......|.|||
Human   106 TLHVSFITPSFPTDG-----------THPFVIQMRPD---LKGALLSLIEYYQWDKFAYLYDSDR 156

  Fly   187 ---------DSFV------------------MDHKYKSLLQNIQ---TRHVITAIAKDGKREREE 221
                     ||..                  .|..|:||.|:::   .|.||.    |.:|::..
Human   157 GLSTLQAVLDSAAEKKWQVTAINVGNINNDKKDEMYRSLFQDLELKKERRVIL----DCERDKVN 217

  Fly   222 QIEKLRNLDINNFFILGTLQSIRMVLESVKPAYFERNFAWHAITQNEGEISSQRDNATIMF---- 282
            .|       ::....:|         :.||        .:|.|..|.|  .:..|...|.|
Human   218 DI-------VDQVITIG---------KHVK--------GYHYIIANLG--FTDGDLLKIQFGGAN 256

  Fly   283 MKPMAYTQYRDRLGLLRTTYNLNEEPQLSSAFYFDLALRSFLTIKEMLQSGAWPKDMEY---LNC 344
            :.......|.|               .|.|.|     :..:.|::|....||....::|   |..
Human   257 VSGFQIVDYDD---------------SLVSKF-----IERWSTLEEKEYPGAHTTTIKYTSALTY 301

  Fly   345 DDFQGGNTPQRNLDLRDYFTKITEPTSYGTFDLVTQSTQPFNGHSFMKFEMDINVLQIRG----- 404
            |..|......||  ||....:|:...:.|  |.:.....|:.  ..::.|..:..:|:.|
Human   302 DAVQVMTEAFRN--LRKQRIEISRRGNAG--DCLANPAVPWG--QGVEIERALKQVQVEGLSGNI 360

  Fly   405 -----GSSVN------------SKSIGKW------------------ISGLNSELIVKDEEQMKN 434
                 |..:|            .:.||.|                  .|||.::.:|
Human   361 KFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTELPSGNDTSGLENKTVV-------- 417

  Fly   435 LTADTVYRIFTVVQAPFIMRDET-----APKGYKGYCIDLINEIAAIVHFDYTIQEVEDGKFGNM 494
                    :.|::::|::|..:.     ..:.|:|||:||..|||....|.|.:..|.|||:|..
Human   418 --------VTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGAR 474

  Fly   495 DENGQ-WNGIVKKLMDKQADIGLGSMSVMAEREIVIDFTVPYYDLVGITIMMQRP-SSPSSLFKF 557
            |.:.: |||:|.:|:..:|||.:..:::...||.||||:.|:..| ||:||:::| .|...:|.|
Human   475 DADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSL-GISIMIKKPQKSKPGVFSF 538

  Fly   558 LTVLETNVWLCILAAYFFTSFLMWIFDRWSPYSYQNNREKYKD------DEEKREFNLKECLWFC 616
            |..|...:|:||:.||...|.::::..|:|||.:  :.|:::|      .|...||.:...|||.
Human   539 LDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEW--HTEEFEDGRETQSSESTNEFGIFNSLWFS 601

  Fly   617 MTSLTPQGGGEAPKNLSGRLVAATWWLFGFIIIASYTANLAAFLTVSRLDTPVESLDDLAKQYKI 681
            :.:...||...:|::||||:|...||.|..|||:||||||||||||.|:.:|:||.:||:||.:|
Human   602 LGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEI 666

  Fly   682 LYAPLNGSSAMTYFERMSNIEQMFYEIWKDLSLNDSLTAVERSKLAVWDYPVSDKYTKMWQAMQE 746
            .|..|:..|...:|                          .|||:||:|        |||..|:.
Human   667 AYGTLDSGSTKEFF--------------------------RRSKIAVFD--------KMWTYMRS 697

  Fly   747 AKLPA----TLDEAVARVRNSTAATGFAFLGDATDIRYL-QLTNCDLQVVGEEFSRKPYAIAVQQ 806
            |: |:    |..|.|||||.|...  :|:|.::|...|: |...||...||.....|.|.||..:
Human   698 AE-PSVFVRTTAEGVARVRKSKGK--YAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPK 759

  Fly   807 GSHLKDQFNNAILTLLNKRQLEKLKEKWW-KNDEALAKCDKPEDQSDGISIQNIGGVFIVIFVGI 870
            ||.|:...|.|:|.|..:..|:|||.||| ...|..||....::::..:|:.|:.|||.::..|:
Human   760 GSSLRTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSGSKEKTSALSLSNVAGVFYILVGGL 824

  Fly   871 GMACITLVFEYWWYRYRKNPRIIDVAEANAERSN 904
            |:|.:..:.|: .|:.|...:.:.||: ||:..|
Human   825 GLAMLVALIEF-CYKSRAEAKRMKVAK-NAQNIN 856

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.