Protein Alignment Ir25a and GRIA1

DIOPT Version :10

• Sequence 1: NP_001260049.1
• Gene: Ir25a / 33683
• FlyBaseID: FBgn0031634
• Length: 947
• Species: Drosophila melanogaster
• Sequence 2: NP_001244950.1
• Gene: GRIA1 / 2890
• HGNCID: 4571
• Length: 916
• Species: Homo sapiens
• Alignment Length: 1021
• Identity: 263/1021 - (25%)
• Similarity: 430/1021 - (42%)
• Gaps: 287/1021 - (28%)

  Fly    39 LFINEVDNEPAAKAVEVVLTYLKKNIRYGLS---------VQLDSIEANKSDAKVLLEAICNKYA 94
            ||.|:...|.||             .|:.||         .|:|.:  |.||:..:....|::::
Human    40 LFPNQQSQEHAA-------------FRFALSQLTEPPKLLPQIDIV--NISDSFEMTYRFCSQFS 89

  Fly    95 TSI------EKKQTPHLILDTTKSGIASETVKSFTQALGLPTISASYGQQGDLRQWRDLDEAKQK 153
            ..:      .:::|.:::             .||..||.:..|:.|:          .:|.:.|
Human    90 KGVYAIFGFYERRTVNML-------------TSFCGALHVCFITPSF----------PVDTSNQ- 130

  Fly   154 YLLQVMPPADIIPEAIRSIVIHMNITNAAILYDDSFVMDHKYKSLLQNI-----QTRHVITAI-- 211
            ::||:.|.   :.:|:.||:.|........:||..     :..|:||.:     :....:||:
Human   131 FVLQLRPE---LQDALISIIDHYKWQKFVYIYDAD-----RGLSVLQKVLDTAAEKNWQVTAVNI 187

  Fly   212 ---AKDGKR----EREEQIEKLRNLDINN---FFILGTLQSIRMVLESVKPAYFERN-FAWHAIT 265
               .::|.|    :.|::.|:|..:|..:   ..|||  |.|::          |:| ..:|.|.
Human   188 LTTTEEGYRMLFQDLEKKKERLVVVDCESERLNAILG--QIIKL----------EKNGIGYHYIL 240

  Fly   266 QNEGEISSQRDNATIMFMKPMAYTQYRDRLGLLRTTYNLNEEPQLSSAFYFDLALRSFLTIKEML 330
            .|.|                                             :.|:.|..|   ||
Human   241 ANLG---------------------------------------------FMDIDLNKF---KE-- 255

  Fly   331 QSGAWPKDMEYLNCDDFQGGNTPQ--RNLDLRDYFTKI----TEPTSYGTFDLVTQSTQPFNGHS 389
             |||.....:.:|..|.......|  :|.|.||: |::    .:.||..|:|.|....:.|  .|
Human   256 -SGANVTGFQLVNYTDTIPAKIMQQWKNSDARDH-TRVDWKRPKYTSALTYDGVKVMAEAF--QS 316

  Fly   390 FMKFEMDIN-------------------------VLQIR-----GGSSVNSK------------- 411
            ..:..:||:                         :.|:|     |....|.|
Human   317 LRRQRIDISRRGNAGDCLANPAVPWGQGIDIQRALQQVRFEGLTGNVQFNEKGRRTNYTLHVIEM 381

  Fly   412 ------SIGKW------ISGLNSELIVKDEEQMKNLTADTVYRIFTVVQAPFIMRDETAPK---- 460
                  .||.|      :..........|...::|.|    |.:.|:::.|::|..:.|.:
Human   382 KHDGIRKIGYWNEDDKFVPAATDAQAGGDNSSVQNRT----YIVTTILEDPYVMLKKNANQFEGN 442

  Fly   461 -GYKGYCIDLINEIAAIVHFDYTIQEVEDGKFGNMD-ENGQWNGIVKKLMDKQADIGLGSMSVMA 523
             .|:|||::|..|||..|.:.|.::.|.|||:|..| :...|||:|.:|:..:||:.:..:::..
Human   443 DRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWNGMVGELVYGRADVAVAPLTITL 507

  Fly   524 EREIVIDFTVPYYDLVGITIMMQRP-SSPSSLFKFLTVLETNVWLCILAAYFFTSFLMWIFDRWS 587
            .||.||||:.|:..| ||:||:::| .|...:|.||..|...:|:||:.||...|.::::..|:|
Human   508 VREEVIDFSKPFMSL-GISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFS 571

  Fly   588 PYSYQNNR-EKYKD---DEEKREFNLKECLWFCMTSLTPQGGGEAPKNLSGRLVAATWWLFGFII 648
            ||.:.:.. |:.:|   .::..||.:...|||.:.:...||...:|::||||:|...||.|..||
Human   572 PYEWHSEEFEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLII 636

  Fly   649 IASYTANLAAFLTVSRLDTPVESLDDLAKQYKILYAPLNGSSAMTYFERMSNIEQMFYEIWKDLS 713
            |:||||||||||||.|:.:|:||.:|||||.:|.|..|...|...:|
Human   637 ISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLEAGSTKEFF------------------ 683

  Fly   714 LNDSLTAVERSKLAVWDYPVSDKYTKMWQAMQEAKLPA----TLDEAVARVRNSTAATGFAFLGD 774
                    .|||:||::        |||..|:.|: |:    |.:|.:.|||.|...  :|:|.:
Human   684 --------RRSKIAVFE--------KMWTYMKSAE-PSVFVRTTEEGMIRVRKSKGK--YAYLLE 729

  Fly   775 ATDIRYL-QLTNCDLQVVGEEFSRKPYAIAVQQGSHLKDQFNNAILTLLNKRQLEKLKEKWWKND 838
            :|...|: |...||...||.....|.|.||..:||.|::..|.|:|.|..:..|:|||.|||.:.
Human   730 STMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSALRNPVNLAVLKLNEQGLLDKLKNKWWYDK 794

  Fly   839 EALAKCDK----PEDQSDGISIQNIGGVFIVIFVGIGMACITLVFEYWWYRYRKNPR------II 893
               .:|..    .:|::..:|:.|:.|||.::..|:|:|.:..:.|: .|:.|...:      :|
Human   795 ---GECGSGGGDSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEF-CYKSRSESKRMKGFCLI 855

  Fly   894 DVAEANAERSNAADHPGKLVDGVILGHSGEK-------FEKSKAAL 932
            .....| |....:..|.....|...|.|||.       |.||..::
Human   856 PQQSIN-EAIRTSTLPRNSGAGASSGGSGENGRVVSHDFPKSMQSI 900

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	37..418	CDD:380606	88/472 (19%)
		PBP2_iGluR_putative	438..836	CDD:270435	146/413 (35%)
GRIA1	NP_001244950.1	PBP1_iGluR_AMPA_GluR1	36..402	CDD:380613	88/474 (19%)
		PBP2_iGluR_AMPA_GluR1	416..797	CDD:270447	149/425 (35%)