DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir25a and Ir41a

DIOPT Version :9

Sequence 1:	NP_001260049.1	Gene:	Ir25a / 33683	FlyBaseID:	FBgn0031634	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	NP_995744.4	Gene:	Ir41a / 2768714	FlyBaseID:	FBgn0040849	Length:	648	Species:	Drosophila melanogaster

Alignment Length:	828	Identity:	153/828 - (18%)
Similarity:	264/828 - (31%)	Gaps:	311/828 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 WRDLDEAKQKYLLQVMPPADIIPEAIRSIVIHMNITNAAILYDDS---FVMDHKYKSLLQNIQTR 205
            |.|      |:..|::..:|.|.      .:.:||.:    :||:   :::|...|.  :.:|.:
  Fly    28 WND------KFEFQLLHKSDYIS------FVGINIKS----FDDNGGHYIIDTGLKK--KELQNK 74

  Fly   206 HVITAIAKDGKREREEQIEKLRNLDINNFFILGTLQSIRMVLESVKPAYFERNFAWHAITQNEGE 270
            |:.                    ||          :.:..::.|::            :|..|..
  Fly    75 HLF--------------------LD----------ELVIKIIISIE------------VTHCETF 97

  Fly   271 ISSQRD-----NATIMFMKPMAYTQYRDRLGLLRTTYNLNEEPQLSSAFYFDLALRSFLTIKEML 330
            :...:|     ||   |.|...|:.:|.........:..||.|:..:.|:.|.....|: :::..
  Fly    98 VVFDKDIDRFVNA---FNKASVYSIWRSLHNKFVFAHIANESPESRNHFFEDQPNILFV-VRDHS 158

  Fly   331 QSGAWPKDMEYLNCDDFQGGNTPQRNLDLRDYFTKITEPTSYGTFDLVTQSTQPFN-GHSFMKFE 394
            .:.::.     :..:.|.|              .|...|:.....|....|.|.|. |.|.  |.
  Fly   159 SASSFD-----IKTNKFVG--------------RKAENPSQMILVDRYLASEQRFQFGKSL--FA 202

  Fly   395 MDINVLQ----------------IRGGSSVNSKSIGKWISGLNSELIVKDEEQMKNLTAD-TVYR 442
            ..:|.||                |:...|.|::.:|  :||         |...||:..| |..|
  Fly   203 DKLNNLQGREVIIAGFDYPPYTVIKHNMSTNAQDMG--VSG---------ESDFKNVYIDGTETR 256

  Fly   443 IFTVVQAPFIMRDETAPKGYKGYCIDLINEIAAIVHFDYTIQ--EVEDGKFGNMDENGQWNGIVK 505
            |..                  .:|          ..|:.|||  ......:|.:..|...:|.:.
  Fly   257 IVL------------------NFC----------EQFNCTIQIDSSAANDWGKVYPNMSGDGALG 293

  Fly   506 KLMDKQADIGLGSMSVMAEREIVIDFTVPYYDLVGITIMMQRPSSPSSLFKFLTVLETNVW---- 566
            .|::::|||.:|:|....|....:|.:: |....|||.::..|...:|.:..|...:..:|
  Fly   294 MLINRKADICIGAMYSWYEDYTYLDLSM-YLVRSGITCLVPAPLRLTSWYLPLEPFKETLWAAIL 357

  Fly   567 LCILAAYFFTSFLMWIFDRWSPYSYQNNREKYKDDEEKREFNLKECLWFCMTS---------LTP 622
            ||:.|.  .|..::......:.|.....||.:               |.| ||         ...
  Fly   358 LCLCAE--ATGLVLAYKSEQALYVLPGYREGW---------------WTC-TSFGVCTTFKLFIS 404

  Fly   623 QGGGEAPKNLSGRLVAATWWLFGFIIIASYTANLAAFLTVSRLDTPVESLDDLAKQYKILYAPLN 687
            |.|.....:|:.|::....:|...||.:.|...||:.||       :.|:|:.|
  Fly   405 QSGNSKAYSLTVRVLLFACFLNDLIITSIYGGGLASILT-------IPSMDEAA----------- 451

  Fly   688 GSSAMTYFERMSNIEQMFYEIWKDLSLNDSLTAVERSKLAVWDYPVSDKYTKMWQAMQEAKLPA- 751
                                        |::|.:...:|             .|.|..||.:.|
  Fly   452 ----------------------------DTVTRLRFHRL-------------QWAANSEAWVSAI 475

  Fly   752 -TLDEAVARVRNSTAATGFAFLGDATDIRY----------LQLTNCDLQVVGEEFSRKP---YAI 802
             ..|||:.:                 ||.|          |:|.......:|....|.|   :||
  Fly   476 RASDEALVK-----------------DILYNFHIYSDDELLRLAQDQHMRIGFTVERLPFGHFAI 523

  Fly   803 -------AVQQGSHLKD----QFNNAILTLLNKRQLEKLK-----------EKWWK----NDEAL 841
                   |:.|...:||    |:..|.:..| ...|:||.           :|:|:    .|...
  Fly   524 GNYLGPQAIDQLVIMKDDIYFQYTVAFVPRL-WPLLDKLNTLIYSWHSSGFDKYWEYRVVADNLN 587

  Fly   842 AKCDKP-EDQSDG--------ISIQNIGGVFIVIFVGIGMACITLVFE 880
            .|..:. ::...|        :.:.|..|..||..:|..:|.:|.:.|
  Fly   588 LKIQQQVQETMTGTKDIGPVPLGMSNFAGFIIVWILGSAIATLTFLLE 635

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	40..426	CDD:107378	52/306 (17%)
		PBP2_iGluR_putative	438..836	CDD:270435	86/450 (19%)
		Lig_chan	565..870	CDD:278489	67/367 (18%)
Ir41a	NP_995744.4	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45463078
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840