Protein Alignment Ir25a and Grin2c

DIOPT Version :10

• Sequence 1: NP_001260049.1
• Gene: Ir25a / 33683
• FlyBaseID: FBgn0031634
• Length: 947
• Species: Drosophila melanogaster
• Sequence 2: XP_017452477.1
• Gene: Grin2c / 24411
• RGDID: 2739
• Length: 1250
• Species: Rattus norvegicus
• Alignment Length: 918
• Identity: 202/918 - (22%)
• Similarity: 344/918 - (37%)
• Gaps: 264/918 - (28%)

  Fly   130 TISASYGQQGDLRQWRDLDEAKQKYL---LQVMP---------PADIIPE--------AIRSIVI 174
            |::..:|..|.|:.........|.:|   |::.|         |:.|:.:        .:..||.
  Rat    44 TVAVVFGSSGPLQTQARTRLTSQNFLDLPLEIQPLTVGVNNTNPSSILTQICGLLGAARVHGIVF 108

  Fly   175 HMNITNAAILYDDSFVMDHKYKSLLQNIQTRHVITAIAKDGKR--------EREEQI--EKLRNL 229
            ..|:...|:.....||....:..:|.......|:....:.|..        |::.|:  :.|...
  Rat   109 EDNVDTEAVAQLLDFVSSQTHVPILSISGGSAVVLTPKEPGSAFLQLGVSLEQQLQVLFKVLEEY 173

  Fly   230 DINNFFILGTLQ-SIRMVLESVKPAYFERNFAWHAITQNEGEIS--------------------- 272
            |.:.|.::.:|. ...:.||.|:........:|..:.....|:.
  Rat   174 DWSAFAVITSLHPGHALFLEGVRAVADASYLSWRLLDVLTLELGPGGPRARTQRLLRQVDAPVLV 238

  Fly   273 --SQRDNATIMFMKPMAYTQYRDRLGLLRTTY-----NL----NEEPQLSSAFYFDLALRSFLT- 325
              ..|:.|.::|.:..       :.||:...:     ||    .:.|..:    |.:.|.|.:|
  Rat   239 AYCSREEAEVLFAEAA-------QAGLVGPGHVWLVPNLALGSTDAPPAA----FPVGLISVVTE 292

  Fly   326 ---------IKE---MLQSGAWPKDMEY-------LNCDDFQGGNTPQRNLDLRDYFTKIT---- 367
                     :::   :|..||.....:|       .:|....|..:|.|....| :...:|
  Rat   293 SWRLSLRQKVRDGVAILALGAHSYRRQYGTLPAPAGDCRSHPGPVSPAREAFYR-HLLNVTWEGR 356

  Fly   368 ----EPTSYGTFDLV--TQSTQPFNGHSFMKFEMDINVLQIRGGSSVNSKSIGKWISGL------ 420
                .|..|    ||  |......|.|..  :||                 :|:|..|:
  Rat   357 DFSFSPGGY----LVRPTMVVIALNRHRL--WEM-----------------VGRWDHGVLYMKYP 398

  Fly   421 ------NSELIVKDEEQMKNLTADTV-YRIFTVVQAP---------------------FIMRDET 457
                  .|...|.|.   ::||..|: .|.|.:|::|                     |...|.|
  Rat   399 VWPRYSTSLQPVVDS---RHLTVATLEERPFVIVESPDPGTGGCVPNTVPCRRQSNHTFSSGDLT 460

  Fly   458 APKGY-----KGYCIDLINEIAAIVHFDYTIQEVEDGKFGNMDENGQWNGIVKKLMDKQADIGLG 517
            .   |     ||:|||::.::|.:|.|.|.:..|.:||.|.. ..|.|||::.::..|:||:.:|
  Rat   461 P---YTKLCCKGFCIDILKKLAKVVKFSYDLYLVTNGKHGKR-VRGVWNGMIGEVYYKRADMAIG 521

  Fly   518 SMSVMAEREIVIDFTVPYYDLVGITIMMQRPSSPSSLFKFLTVLETNVW-----LCILAAYFFTS 577
            |:::..||..:|||:||:.: .||::|:.|.:...|...||......||     :|:..    .:
  Rat   522 SLTINEERSEIIDFSVPFVE-TGISVMVSRSNGTVSPSAFLEPYSPAVWVMMFVMCLTV----VA 581

  Fly   578 FLMWIFDRWSPYSYQNNREKYKDDEEKREFNLKECLW----FCMTSLTPQGGGEAPKNLSGRLVA 638
            ..:::|:.:||.||..|..|.|..... .|.:.:.:|    ....:..|.   |.|:..:.:::.
  Rat   582 ITVFMFEYFSPVSYNQNLTKGKKPGGP-SFTIGKSVWLLWALVFNNSVPI---ENPRGTTSKIMV 642

  Fly   639 ATWWLFGFIIIASYTANLAAFLTVSRLDTPVESLDDLAKQY---KILYAPL------NGSSAMTY 694
            ..|..|..|.:||||||||||:...:....|..|.|  |::   :..|.|.      |||:
  Rat   643 LVWAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSD--KKFQRPQDQYPPFRFGTVPNGST---- 701

  Fly   695 FER--MSNIEQMFYEIWK--DLSLNDSLTAVERSKLAVWDYPVSDKYTKMWQAMQEAKLPATLDE 755
             ||  .||...|...:.|  ..|:.|:||:::..||.
  Rat   702 -ERNIRSNYRDMHTHMVKFNQRSVEDALTSLKMGKLD---------------------------- 737

  Fly   756 AVARVRNSTAATGFAFLGDATDIRYL--QLTNCDLQVV--GEEFSRKPYAIAVQQGSHLKDQFNN 816
                          ||:.||..:.|:  :...|.|..:  |:.|:...|.||:|:.||.|...:.
  Rat   738 --------------AFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDL 788

  Fly   817 AILTLLNKRQLEKLKEKWWKNDEALAKCDKPEDQSDGISIQNIGGVFIVIFVGIGMACITLVFE- 880
            |:|.||...:.:||:..|.   ..:.:.:|.|..|..:.|.|:.|||.::.|.:|:|.:...:|
  Rat   789 ALLQLLGDGETQKLETVWL---SGICQNEKNEVMSSKLDIDNMAGVFYMLLVAMGLALLVFAWEH 850

  Fly   881 --YWWYRY 886
              ||..|:
  Rat   851 LVYWKLRH 858

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	37..418	CDD:380606	63/380 (17%)
		PBP2_iGluR_putative	438..836	CDD:270435	118/450 (26%)
Grin2c	XP_017452477.1	PBP1_iGluR_NMDA_NR2	41..397	CDD:380601	64/387 (17%)
		PBP2_iGluR_NMDA_Nr2	413..813	CDD:270436	120/467 (26%)
		NMDAR2_C	850..>925	CDD:463148	3/9 (33%)