DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir25a and Grin2b

DIOPT Version :9

Sequence 1:NP_001260049.1 Gene:Ir25a / 33683 FlyBaseID:FBgn0031634 Length:947 Species:Drosophila melanogaster
Sequence 2:NP_036706.1 Gene:Grin2b / 24410 RGDID:2738 Length:1482 Species:Rattus norvegicus


Alignment Length:995 Identity:223/995 - (22%)
Similarity:382/995 - (38%) Gaps:268/995 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 NPKTSKILWL-LGFLSLLSSFSLEIAAQTTQNINVLFINEVDNEPAAKAVEVVLTYLKKNIRYGL 68
            :||    .|| |..|::..|.:....:..:..|.|:.:...| |.|.|...      :|:..:.|
  Rat     9 SPK----FWLVLAVLAVSGSKARSQKSPPSIGIAVILVGTSD-EVAIKDAH------EKDDFHHL 62

  Fly    69 SV--QLDSIEANKSDAKVLLEAICNKYATSIEKKQTPHLILDTTKSGIASETVKSFTQALGLPTI 131
            ||  :::.:..|::|.|.::..||:  ..|..|.|......||.:..||.  :..|..|..|..|
  Rat    63 SVVPRVELVAMNETDPKSIITRICD--LMSDRKIQGVVFADDTDQEAIAQ--ILDFISAQTLTPI 123

  Fly   132 SASYGQQGDLRQWRDLDEAKQKY------------LLQVMPPADIIPEAIRSIVIHMNITNAAIL 184
            ...:|  |......|.||:...:            :|.:|...|..   |.|||     |.....
  Rat   124 LGIHG--GSSMIMADKDESSMFFQFGPSIEQQASVMLNIMEEYDWY---IFSIV-----TTYFPG 178

  Fly   185 YDDSFVMDHKYKSLLQN------IQTRHVITAIAKDGKREREEQIEKLRNLDINNFFILGTLQSI 243
            |.| ||  :|.:|.::|      ::...::.....||..:.:.|::||::..|..:........|
  Rat   179 YQD-FV--NKIRSTIENSFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSPIILLYCTKEEATYI 240

  Fly   244 RMVLESVKPAYFERNFAW---HAITQNEGEISSQRDNATIMFMKPMAYTQY--------RDRLGL 297
            ..|..||....:  .:.|   ..:..:...:.|:.....|    .::|.::        ||.:.:
  Rat   241 FEVANSVGLTGY--GYTWIVPSLVAGDTDTVPSEFPTGLI----SVSYDEWDYGLPARVRDGIAI 299

  Fly   298 LRTTYNLNEEPQLSSAFYFDLALRSFLTIKEMLQSGAW---PKDMEYLNCDDFQGGNTPQRNL-- 357
            :.|                        ...:||...::   ||...|         ||.::.:  
  Rat   300 ITT------------------------AASDMLSEHSFIPEPKSSCY---------NTHEKRIYQ 331

  Fly   358 --DLRDYFTKITEPTSYGTFDLVTQSTQPFNGH--SFMK--FEMDINVLQIRGGSSVNSKSIGKW 416
              .|..|...:|                 |.|.  ||.:  ::|...::.|........:.:|||
  Rat   332 SNMLNRYLINVT-----------------FEGRNLSFSEDGYQMHPKLVIILLNKERKWERVGKW 379

  Fly   417 ISGLNSELIVKDEE-QMKNLT-----------ADTVYRIFTVVQAPFIMRDETAP---------- 459
                      ||:. |||...           .|....|.|:.:|||::.:...|          
  Rat   380 ----------KDKSLQMKYYVWPRMCPETEEQEDDHLSIVTLEEAPFVIVESVDPLSGTCMRNTV 434

  Fly   460 ---------------KGY-----KGYCIDLINEIAAIVHFDYTIQEVEDGKFGNMDENGQWNGIV 504
                           .||     ||:|||::.:|:..|.|.|.:..|.:||.|. ..||.|||::
  Rat   435 PCQKRIISENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLYLVTNGKHGK-KINGTWNGMI 498

  Fly   505 KKLMDKQADIGLGSMSVMAEREIVIDFTVPYYDLVGITIMMQRPSSPSSLFKFLTVLETNVWLCI 569
            .:::.|:|.:.:||:::..||..|:||:||:.: .||::|:.|.:...|...||.....:||:.:
  Rat   499 GEVVMKRAYMAVGSLTINEERSEVVDFSVPFIE-TGISVMVSRSNGTVSPSAFLEPFSADVWVMM 562

  Fly   570 LAAYFFTSFL-MWIFDRWSPYSYQNNREKYKDDEEK--REFNLKECLWFCM-----TSLTPQGGG 626
            .......|.: :::|:.:||..|  || ...|..|.  ..|.:.:.:|...     .|:..|.  
  Rat   563 FVMLLIVSAVAVFVFEYFSPVGY--NR-CLADGREPGGPSFTIGKAIWLLWGLVFNNSVPVQN-- 622

  Fly   627 EAPKNLSGRLVAATWWLFGFIIIASYTANLAAFLTVSRLDTPVESLDDLAKQYKILYAP------ 685
              ||..:.:::.:.|..|..|.:||||||||||:........|..|.|...|....::|      
  Rat   623 --PKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGT 685

  Fly   686 -LNGSSAMTYFERMSNIEQMFYEI------WKDLSLNDSLTAVERSKLAVWDYPVSDKYTKMWQA 743
             .|||:     ||  ||...:.|:      :....::|:|.:::..||.                
  Rat   686 VPNGST-----ER--NIRNNYAEMHAYMGKFNQRGVDDALLSLKTGKLD---------------- 727

  Fly   744 MQEAKLPATLDEAVARVRNSTAATGFAFLGDATDIRYL--QLTNCDLQVV--GEEFSRKPYAIAV 804
                                      ||:.||..:.|:  :...|.|..:  |:.|:...|.||:
  Rat   728 --------------------------AFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAI 766

  Fly   805 QQGSHLKDQFNNAILTLLNKRQLEKLKEKWWKNDEALAKCDKPEDQSDGISIQNIGGVFIVIFVG 869
            |:.|..|.|.:.|||.|....::|:|:..|.   ..:...:|.|..|..:.|.|:.|||.::...
  Rat   767 QKDSGWKRQVDLAILQLFGDGEMEELEALWL---TGICHNEKNEVMSSQLDIDNMAGVFYMLGAA 828

  Fly   870 IGMACITLVFE---YWWYRY 886
            :.::.||.:.|   ||.:|:
  Rat   829 MALSLITFICEHLFYWQFRH 848

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
Ir25aNP_001260049.1 PBP1_iGluR_AMPA_Like 40..426 CDD:107378 80/427 (19%)
PBP2_iGluR_putative 438..836 CDD:270435 115/452 (25%)
Lig_chan 565..870 CDD:278489 78/329 (24%)
Grin2bNP_036706.1 PBP1_iGluR_NMDA_NR2 33..393 CDD:107373 87/449 (19%)
PBP2_iGluR_NMDA_Nr2 403..803 CDD:270436 115/460 (25%)
HisJ <459..>542 CDD:223904 32/84 (38%)
Lig_chan 557..829 CDD:278489 78/330 (24%)
Pore-forming. /evidence=ECO:0000269|PubMed:24876489, ECO:0000305|PubMed:24876489 604..623 3/22 (14%)