Protein Alignment Ir25a and Grin1

DIOPT Version :10

• Sequence 1: NP_001260049.1
• Gene: Ir25a / 33683
• FlyBaseID: FBgn0031634
• Length: 947
• Species: Drosophila melanogaster
• Sequence 2: NP_001257531.1
• Gene: Grin1 / 24408
• RGDID: 2736
• Length: 959
• Species: Rattus norvegicus
• Alignment Length: 1048
• Identity: 234/1048 - (22%)
• Similarity: 406/1048 - (38%)
• Gaps: 253/1048 - (24%)

  Fly    14 LLGFLSLLS-SFSLEIAAQTTQNINVLFINEVDNEPAAKAVEVVLTYLKKNIRYG-LSVQLDSIE 76
            ||.|..|.| ||:.........||..:.......:...:||.      :.|.|:| ..:||::..
  Rat     6 LLTFALLFSCSFARAACDPKIVNIGAVLSTRKHEQMFREAVN------QANKRHGSWKIQLNATS 64

  Fly    77 -ANKSDAKVLLEAICNK------YATSIEKKQTP--HLILDTTKSGIASETVKSFT------QAL 126
             .:|.:|..:..::|..      ||..:....||  |.          :.|..|:|      ..|
  Rat    65 VTHKPNAIQMALSVCEDLISSQVYAILVSHPPTPNDHF----------TPTPVSYTAGFYRIPVL 119

  Fly   127 GLPTISASYGQQGDLRQWRDLDEAKQKYLLQVMPP----ADIIPEAIRSIVIHMNITNAAILYDD 187
            ||.|..:.|.           |::.....|:.:||    :.:..|.:|.    .|..:..:|..|
  Rat   120 GLTTRMSIYS-----------DKSIHLSFLRTVPPYSHQSSVWFEMMRV----YNWNHIILLVSD 169

  Fly   188 SFVMDHKYKSLLQNIQTRHVITAIAKDGKREREEQIEKLRNLDINN----------FFILGTLQS 242
                ||:.::..:.::     |.:.:...:.::...|.|..|..:|          .|..||...
  Rat   170 ----DHEGRAAQKRLE-----TLLEERESKSKKRNYENLDQLSYDNKRGPKAEKVLQFDPGTKNV 225

  Fly   243 IRMVLESVKPAYFERNFAWHAITQNEGEISSQRDNATIMF----MKPMAYTQY------------ 291
            ..:::|:       |......|.     :|:..|:|..::    |..|..:.|
  Rat   226 TALLMEA-------RELEARVII-----LSASEDDAATVYRAAAMLNMTGSGYVWLVGEREISGN 278

  Fly   292 -----RDRLGLLRTTYNLNEEPQLSSAFYFDLALRSFLTIKEMLQSGAWPKDMEYLNCDDFQGGN 351
                 .|.:..|:.....||...:|.|  ..:..::   :.|:|         |..|..|...|.
  Rat   279 ALRYAPDGIIGLQLINGKNESAHISDA--VGVVAQA---VHELL---------EKENITDPPRGC 329

  Fly   352 TPQRNL-DLRDYFTKITEPTSY-----GTFDLVTQSTQPFNGHSFMKFEMDINVLQ--IRGGSSV 408
            ....|: .....|.::...:.|     |..:......:.|..:|.|..: :..::|  |..|:.|
  Rat   330 VGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQ-NRKLVQVGIYNGTHV 393

  Fly   409 --NSKSIGKWISGLNSELIVKDEEQMKNLTADTVYRIFTVVQAPFI-----MRD----------- 455
              |.:.| .|..|        :.|:.:.....|..:|.|:.|.||:     |.|
  Rat   394 IPNDRKI-IWPGG--------ETEKPRGYQMSTRLKIVTIHQEPFVYVKPTMSDGTCKEEFTVNG 449

  Fly   456 --------------------ETAPKGYKGYCIDLINEIAAIVHFDYTIQEVEDGKFG-----NMD 495
                                .|.|:...|:||||:.::|..::|.|.:..|.|||||     |..
  Rat   450 DPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVADGKFGTQERVNNS 514

  Fly   496 ENGQWNGIVKKLMDKQADIGLGSMSVMAEREIVIDFTVPY-YDLVGITIMMQRPSSPSSLFKFLT 559
            ...:|||::.:|:..|||:.:..:::..||...|:|:.|: |.  |:||::::....|:|..|:.
  Rat   515 NKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQ--GLTILVKKEIPRSTLDSFMQ 577

  Fly   560 VLETNVWLCILAAYFFTSFLMWIFDRWSPYS-YQNNREKYKDDEEKREFNLKECLWFCMTSLTPQ 623
            ..::.:||.:..:....:.::::.||:||:. ::.|.|    :||:....|...:||....|...
  Rat   578 PFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSE----EEEEDALTLSSAMWFSWGVLLNS 638

  Fly   624 GGGE-APKNLSGRLVAATWWLFGFIIIASYTANLAAFLTVSRLDTPVESLDDLAKQY---KILYA 684
            |.|| ||::.|.|::...|..|..||:|||||||||||.:.|.:..:..::|...:.   |.:||
  Rat   639 GIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDKFIYA 703

  Fly   685 PLNGSSAMTYFERMSNIEQMFYEIWKDLSLNDSLTAVERSKLAVWDYPVSDKYTKMWQAMQEAKL 749
            .:..||...||.|...:..|:..:.|. :...:..|:                    ||:::.||
  Rat   704 TVKQSSVDIYFRRQVELSTMYRHMEKH-NYESAAEAI--------------------QAVRDNKL 747

  Fly   750 PATLDEAVARVRNSTAATGFAFLGDATDIRYLQLTNCDLQVVGEEFSRKPYAIAVQQGSHLKDQF 814
                               .||:.|:..:.:.....|||...||.|.|..:.|.:::.|..|...
  Rat   748 -------------------HAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNV 793

  Fly   815 NNAILTLLNKRQLEKLKEKWWKNDEALAKCDKPEDQSDGISIQNIGGVFIVIFVGIGMACITLVF 879
            :.:||.......:|.|.:.|.:..|    ||...:....::.:|:.|||:::..|| :|.|.|:|
  Rat   794 SLSILKSHENGFMEDLDKTWVRYQE----CDSRSNAPATLTFENMAGVFMLVAGGI-VAGIFLIF 853

  Fly   880 EYWWYRYRKNPR----IIDVAEANAERSNAADHPGKLVDGVILGHSG--EKFEKSKAALRPRFNQ 938
            ....|:..|:.|    .:..|..|..|.|..|.           .||  |...|.||..|...:.
  Rat   854 IEIAYKRHKDARRKQMQLAFAAVNVWRKNLQDR-----------KSGRAEPDPKKKATFRAITST 907

  Fly   939 YPATFKPR 946
            ..::||.|
  Rat   908 LASSFKRR 915

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	37..418	CDD:380606	77/441 (17%)
		PBP2_iGluR_putative	438..836	CDD:270435	115/444 (26%)
Grin1	NP_001257531.1	PBP1_iGluR_NMDA_NR1	25..404	CDD:380602	79/446 (18%)
		PBP2_iGluR_NMDA_Nr1	416..820	CDD:270437	116/453 (26%)
		CaM_bdg_C0	856..884	CDD:402271	7/27 (26%)