DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir25a and Grik5

DIOPT Version :9

Sequence 1:	NP_001260049.1	Gene:	Ir25a / 33683	FlyBaseID:	FBgn0031634	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	XP_006228444.1	Gene:	Grik5 / 24407	RGDID:	2735	Length:	980	Species:	Rattus norvegicus

Alignment Length:	897	Identity:	227/897 - (25%)
Similarity:	394/897 - (43%)	Gaps:	172/897 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 INEVDNEPAAKAVEVVLTYLKKNIRYGLSVQLDSIEANKSDAKVLLEAICNKYATSIEKKQTPHL 105
            ||.:...||...|||.:..|:::.:|         |...:..::|.:.:.:
  Rat    51 INGIIEVPAKARVEVDIFELQRDSQY---------ETTDTMCQILPKGVVS-------------- 92

  Fly   106 ILDTTKSGIASETVKSFTQALGLPTISASYGQQGDLRQWRDLDEAKQKYL----LQVMPPADIIP 166
            :|..:.|..::.||........:|.|..  |.:         :..:.:||    :.:.|..:.:.
  Rat    93 VLGPSSSPASASTVSHICGEKEIPHIKV--GPE---------ETPRLQYLRFASVSLYPSNEDVS 146

  Fly   167 EAIRSIVIHMNITNAAILYDDSFVMDHKYKSLLQNIQTRHVITAIAKDGKREREEQIEKLRNLDI 231
            .|:..|:...|..:|:::...:..:....:.:...:.::..::....|..|:....::::|:..:
  Rat   147 LAVSRILKSFNYPSASLICAKAECLLRLEELVRGFLISKETLSVRMLDDSRDPTPLLKEIRDDKV 211

  Fly   232 NNFFILGTLQSIRMVLESVKPAYFERNFAWHAITQNEGEI----SSQRDNATIM--FMKPMAYTQ 290
            :...|........:||...........|..:.:|..:..|    ....|::.|:  .|...::..
  Rat   212 STIIIDANASISHLVLRKASELGMTSAFYKYILTTMDFPILHLDGIVEDSSNILGFSMFNTSHPF 276

  Fly   291 YRDRLGLLRTTYNLNEE------PQLSSAFYFDLALRSFLTIKEMLQS-------------GAWP 336
            |.:.:..|..::..|.|      |.||:|..||........::|:.:|             ..||
  Rat   277 YPEFVRSLNMSWRENCEASTYPGPALSAALMFDAVHVVVSAVRELNRSQEIGVKPLACTSANIWP 341

  Fly   337 KD---MEYLNCDDFQGGNTPQRNLDLRDYFTKITEPTSYGTFDLVTQSTQPFNGHSFMKFEMDIN 398
            ..   |.||...::.|       |..|..|....:.|:| |..::.:|.|   ||
  Rat   342 HGTSLMNYLRMVEYDG-------LTGRVEFNSKGQRTNY-TLRILEKSRQ---GH---------- 385

  Fly   399 VLQIRGGSSVNSKSIGKWIS----GLNSELIVKDEEQMKNLTADTVYRIFTVVQAPFIMRDE--- 456
                        :.||.|.|    .:|:..:   :..:....|:....:.|:::.|::||..
  Rat   386 ------------REIGVWYSNRTLAMNATTL---DINLSQTLANKTLVVTTILENPYVMRRPNFQ 435

  Fly   457 --TAPKGYKGYCIDLINEIAAIVHFDYTIQEVEDGKFGNMDENGQWNGIVKKLMDKQ-ADIGLGS 518
              :..:.::|:|:|::.|:|.::.|.|.::.||||.:|..:.||.|.|:|.:|:::| ||:.:.:
  Rat   436 ALSGNERFEGFCVDMLRELAELLRFRYRLRLVEDGLYGAPEPNGSWTGMVGELINRQKADLAVAA 500

  Fly   519 MSVMAEREIVIDFTVPYYDLVGITI-----MMQRPSSPSSLFKFLTVLETNVWLCILAAYFFTSF 578
            .::.||||.||||:.|:..| ||:|     |.::|    ..|.||......|||.:|.||...|.
  Rat   501 FTITAEREKVIDFSKPFMTL-GISILYRVHMGRKP----GYFSFLDPFSPAVWLFMLLAYLAVSC 560

  Fly   579 LMWIFDRWSPYSYQNNRE--KYKDDEEKREFNLKECLWFCMTSLTPQGGGEAPKNLSGRLVAATW 641
            ::::..|.|||.:.|...  :.:....:.::.|...|||.:.....||....|:.||.|.|:..|
  Rat   561 VLFLAARLSPYEWYNPHPCLRARPHILENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVW 625

  Fly   642 WLFGFIIIASYTANLAAFLTVSRLDTPVESLDDLAKQYKILYAPLNGSSAMTYFERMSNIEQMFY 706
            |.|..|||:||||||||||||.|::.||||.||||.|..|.|..::..|.||:|:...      |
  Rat   626 WAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFFQNSR------Y 684

  Fly   707 EIWKDLSLNDSLTAVERSKLAVWDYPVSDKYTKMWQAMQEAKLPA----TLDEAVARVRNSTAAT 767
            :                            .|.:||..|| :|.|:    :.:|.:|||.||.
  Rat   685 Q----------------------------TYQRMWNYMQ-SKQPSVFVKSTEEGIARVLNSR--- 717

  Fly   768 GFAFLGDATDIRYLQLTNCDLQVVGEEFSRKPYAIAVQQGSHLKDQFNNAILTLLNKRQLEKLKE 832
             :|||.::|...|.:..||:|..:|.....|.|.|.:..||..:|:...|||.|....:||.||.
  Rat   718 -YAFLLESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKR 781

  Fly   833 KWWKNDEALAKCDKPED-QSDGISIQNIGGVFIVIFVGIGMACITLVFEYWW 883
            |||:.    .:|.|.|| ::.|:.::||||:|:|:..|:.:|....|.|:.|
  Rat   782 KWWEG----GRCPKEEDHRAKGLGMENIGGIFVVLICGLIIAVFVAVMEFIW 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	40..426	CDD:107378	70/420 (17%)
		PBP2_iGluR_putative	438..836	CDD:270435	139/414 (34%)
		Lig_chan	565..870	CDD:278489	108/311 (35%)
Grik5	XP_006228444.1	PBP1_iGluR_Kainate_KA1_2	23..401	CDD:380616	69/416 (17%)
Grik5	XP_006228444.1	Periplasmic_Binding_Protein_Type_2	414..785	CDD:389745	139/414 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350220
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.740