Protein Alignment Ir25a and Grin3a

DIOPT Version :10

• Sequence 1: NP_001260049.1
• Gene: Ir25a / 33683
• FlyBaseID: FBgn0031634
• Length: 947
• Species: Drosophila melanogaster
• Sequence 2: NP_001263284.1
• Gene: Grin3a / 242443
• MGIID: 1933206
• Length: 1135
• Species: Mus musculus
• Alignment Length: 959
• Identity: 198/959 - (20%)
• Similarity: 359/959 - (37%)
• Gaps: 281/959 - (29%)

  Fly    40 FINEVDNEPAAKAVEVVLTYLKKNIRYGLSVQLDSIEANKSDAKVLLEAICNKYATSIEKKQTP- 103
            |:..|.:....:.|..:|.:.:..   |..::||           |:.::.:....||.:.:.|
Mouse   180 FLQSVCHTVVVQGVSALLAFPQSQ---GEMMELD-----------LVSSVLHIPVLSIVRHEFPR 230

  Fly   104 --------HLILDTTKSGIASETVKSFTQALGLPTISASYG-------QQGDLRQWRDLDEAKQK 153
                    .|.|:.:.|..|..||       .:.|::..|.       :..::..:..|.|...|
Mouse   231 ESQNPLHLQLSLENSLSSDADVTV-------SILTMNNWYNFSLLLCQEDWNITDFLLLTENNSK 288

  Fly   154 YLLQVMPPADIIPEAIRSIVIHMNITNAAILYDDSFVMDHKYKSLLQNIQTRHVITAIAKDGKRE 218
            :.|          |:|.:|..:::.|                |.||..:|.
Mouse   289 FHL----------ESIINITANLSST----------------KDLLSFLQV-------------- 313

  Fly   219 REEQIEKLRNLDINNFFILGTLQSIRMVLE-SVKPAYFERNFAW-HAITQNEGEISSQRDNATIM 281
               |:|.:||...........:.|||.:.| |.:......:..| ...:||..|:.::.
Mouse   314 ---QLENIRNSTPTMVMFGCDMGSIRQIFEMSTQFGLSPPDLHWVLGDSQNVEELRTEG------ 369

  Fly   282 FMKPMAYTQYRDRLGLL---RTTYNLNEEPQLSSAFY----FDLALRSFLTIKEMLQS--GAWPK 337
              .|         |||:   :||.::.|       :|    .:|..|:..| ..|:|.  ...|.
Mouse   370 --LP---------LGLIAHGKTTQSVFE-------YYVQDAMELVARAVAT-ATMIQPELALLPS 415

  Fly   338 DMEYLNCDDFQGGNTPQRNLDLRDYFTKITEPTSYGTFDLVTQSTQPFNGHSFMKFEMDINVLQI 402
            .|   ||.|.:     ..||....|.::....|:             |.|.|        ..:::
Mouse   416 TM---NCMDVK-----TTNLTSGQYLSRFLANTT-------------FRGLS--------GSIKV 451

  Fly   403 RGGSSVNSKS-------------------IGKWISGLNSELIVKD-----EEQMKNLT----ADT 439
            :|.:.|:|::                   :|.|..|    .||.|     |:..::.|    .:.
Mouse   452 KGSTIVSSENNFFIWNLQYDPMGKPMWTRLGSWQGG----RIVMDSGIWPEQAQRHKTHFHHPNK 512

  Fly   440 VY-RIFTVVQAPFIM------------------------------------RDETAPKGYK---- 463
            :: |:.|:::.||:.                                    .::|.|..:|
Mouse   513 LHLRVVTLIEHPFVFTREVDDEGLCPAGQLCLDPMTNDSSILDSLFSSLHSSNDTVPIKFKKCCY 577

  Fly   464 GYCIDLINEIAAIVHFDYTIQEVEDGKFGNMDENGQWNGIVKKLMDKQADIGLGSMSVMAEREIV 528
            ||||||:.::|..::||:.:..|.|||:|.. :||.|.|:|..|:...|::.:.|.|:...|..|
Mouse   578 GYCIDLLEQLAEDMNFDFDLYIVGDGKYGAW-KNGHWTGLVGDLLSGTANMAVTSFSINTARSQV 641

  Fly   529 IDFTVPYYDL-VGITIMMQRPSSPSSLFKFLTVLETNVWLCILAAYFFTSFLMWIFDRWSPYSYQ 592
            ||||.|::.. :||.:..:..::|  :..|:..|...:||.|..|...|:..:.:::..||:...
Mouse   642 IDFTSPFFSTSLGILVRTRDTAAP--IGAFMWPLHWTMWLGIFVALHITAIFLTLYEWKSPFGMT 704

  Fly   593 ---NNREKYKDDEEKREFNLKECLWFCMTSLTPQGGG-EAPKNLSGRLVAATWWLFGFIIIASYT 653
               .||.|.        |:....|..|...|..:... :.||..:||.:...|.:|....:::||
Mouse   705 PKGRNRNKV--------FSFSSALNVCYALLFGRTAAIKPPKCWTGRFLMNLWAIFCMFCLSTYT 761

  Fly   654 ANLAAFLTVSRLDTPVESLDDLAKQYKILYAPLNGSSAMTYFERMSNIEQMFYEIWKDLSLNDSL 718
            |||||.:...::...:..:.|     ..|:.|..|.       |...:.:...|
Mouse   762 ANLAAVMVGEKIYEELSGIHD-----PKLHHPSQGF-------RFGTVRESSAE----------- 803

  Fly   719 TAVERSKLAVWDYPVSDKYTKMWQAMQEAKLPATLDEAVARVRNSTAATGFAFLGDATDIRY-LQ 782
                       || |...:.:|.:.|:...:|||.| .|..::|...... ||:.|...:.| :.
Mouse   804 -----------DY-VRQSFPEMHEYMRRYNVPATPD-GVQYLKNDPEKLD-AFIMDKALLDYEVS 854

  Fly   783 L-TNCDLQVVGEEFSRKPYAIAVQQGSHLKDQFNNAILTLLNKRQLEKLKEKWWKNDEALAKCDK 846
            : .:|.|..||:.|:.:.|.|.:...|.|....:..|....:...::.|.:||:|    :..|.|
Mouse   855 IDADCKLLTVGKPFAIEGYGIGLPPNSPLTSNISELISQYKSHGFMDVLHDKWYK----VVPCGK 915

  Fly   847 PE---DQSDGISIQNIGGVFIVIFVGIGMACITLVFEYWWYRYRKNPRI 892
            ..   .::..:.|::..|:|:::.:|.|::.:|.:.|:..||... |||
Mouse   916 RSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHIVYRLLL-PRI 963

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	37..418	CDD:380606	74/423 (17%)
		PBP2_iGluR_putative	438..836	CDD:270435	103/445 (23%)
Grin3a	NP_001263284.1	PBP1_iGluR_NMDA_NR3	40..496	CDD:380600	78/437 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	59..118
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	102/443 (23%)
		Lig_chan	674..941	CDD:459656	67/315 (21%)
		PPP2CB binding site. /evidence=ECO:0000250|UniProtKB:Q9R1M7	951..987		6/14 (43%)
		GIT1-binding. /evidence=ECO:0000250|UniProtKB:Q9R1M7	1082..1115