DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir25a and Grin3a

DIOPT Version :9

Sequence 1:	NP_001260049.1	Gene:	Ir25a / 33683	FlyBaseID:	FBgn0031634	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	NP_612555.1	Gene:	Grin3a / 191573	RGDID:	621704	Length:	1135	Species:	Rattus norvegicus

Alignment Length:	1037	Identity:	207/1037 - (19%)
Similarity:	379/1037 - (36%)	Gaps:	314/1037 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 YGLSVQ-LDSIEANKSDAKVL----------------LEAICNKYAT-------SIEKKQTPHLI 106
            |.||:: :.:|||...|..::                |:::|:....       :..:.|...:.
  Rat   144 YNLSLEVVMAIEAGLGDLPLMPFSSPSSPWSSDPFSFLQSVCHTVVVQGVSALLAFPQSQGEMME 208

  Fly   107 LDTTKSGIASETVKSFTQALGLPTISASYGQ-----QGDLRQWRDLDEAKQKYLLQVMPPADIIP 166
            ||...|            .|.:|.:|....:     |..|.....|:.:       :...||:..
  Rat   209 LDLVSS------------VLHIPVLSIVRHEFPRESQNPLHLQLSLENS-------LSSDADVTV 254

  Fly   167 EAIRSIVIHMNITNAAIL--YDDSFVMDHKYKSLLQNIQTRHVITAI--------AKDGKREREE 221
                ||:...|..|.::|  .:|..:.|  :..|.:|....|:.:.|        .||.....:.
  Rat   255 ----SILTMNNWYNFSLLLCQEDWNITD--FLLLTENNSKFHLESVINITANLSSTKDLLSFLQV 313

  Fly   222 QIEKLRNLDINNFFILGTLQSIRMVLE-SVKPAYFERNFAW-HAITQNEGEISSQRDNATIMFMK 284
            |::.:||...........:.|||.:.| |.:.........| ...:||..|:.::.        .
  Rat   314 QMDNIRNSTPTMVMFGCDMDSIRQIFEMSTQFGLSPPELHWVLGDSQNVEELRTEG--------L 370

  Fly   285 PMAYTQYRDRLGLL---RTTYNLNEEPQLSSAFY----FDLALRSFLTIKEMLQS--GAWPKDME 340
            |         |||:   :||.::.|       :|    .:|..|:..| ..|:|.  ...|..|
  Rat   371 P---------LGLIAHGKTTQSVFE-------YYVQDAMELVARAVAT-ATMIQPELALLPSTM- 417

  Fly   341 YLNCDDFQGGNTPQRNLDLRDYFTKITEPTSYGTFDLVTQSTQPFNGHSFMKFEMDINVLQIRGG 405
              ||.|.:     ..||....|.::....|:             |.|.|        ..::::|.
  Rat   418 --NCMDVK-----TTNLTSGQYLSRFLANTT-------------FRGLS--------GSIKVKGS 454

  Fly   406 SSVNSKS-------------------IGKWISGLNSELIVKD-----EEQMKNLT----ADTVY- 441
            :.::|::                   :|.|..|    .||.|     |:..::.|    .:.::
  Rat   455 TIISSENNFFIWNLQHDPMGKPMWTRLGSWQGG----RIVMDSGIWPEQAQRHKTHFQHPNKLHL 515

  Fly   442 RIFTVVQAPFIM------------------------------------RDETAPKGYK----GYC 466
            |:.|:::.||:.                                    .::|.|..:|    |||
  Rat   516 RVVTLIEHPFVFTREVDDEGLCPAGQLCLDPMTNDSSMLDRLFSSLHSSNDTVPIKFKKCCYGYC 580

  Fly   467 IDLINEIAAIVHFDYTIQEVEDGKFGNMDENGQWNGIVKKLMDKQADIGLGSMSVMAEREIVIDF 531
            |||:.::|..::||:.:..|.|||:|.. :||.|.|:|..|:...|::.:.|.|:...|..||||
  Rat   581 IDLLEQLAEDMNFDFDLYIVGDGKYGAW-KNGHWTGLVGDLLSGTANMAVTSFSINTARSQVIDF 644

  Fly   532 TVPYYDL-VGITIMMQRPSSPSSLFKFLTVLETNVWLCILAAYFFTSFLMWIFDRWSPYSYQ--- 592
            |.|::.. :||.:..:..::|  :..|:..|...:||.|..|...|:..:.:::..||:...
  Rat   645 TSPFFSTSLGILVRTRDTAAP--IGAFMWPLHWTMWLGIFVALHITAIFLTLYEWKSPFGMTPKG 707

  Fly   593 NNREKYKDDEEKREFNLKECLWFCMTSLTPQGGG-EAPKNLSGRLVAATWWLFGFIIIASYTANL 656
            .||.|.        |:....|..|...|..:... :.||..:||.:...|.:|....:::|||||
  Rat   708 RNRNKV--------FSFSSALNVCYALLFGRTAAIKPPKCWTGRFLMNLWAIFCMFCLSTYTANL 764

  Fly   657 AAFLTVSRLDTPVESLDDLAKQYKILYAPLNGSSAMTYFERMSNIEQMFYEIWKDLSLNDSLTAV 721
            ||.:...::...:..:.|     ..|:.|..|.       |...:.:...|
  Rat   765 AAVMVGEKIYEELSGIHD-----PKLHHPSQGF-------RFGTVRESSAE-------------- 803

  Fly   722 ERSKLAVWDYPVSDKYTKMWQAMQEAKLPATLDEAVARVRNSTAATGFAFLGDATDIRY-LQL-T 784
                    || |...:.:|.:.|:...:|||.| .|..::|...... ||:.|...:.| :.: .
  Rat   804 --------DY-VRQSFPEMHEYMRRYNVPATPD-GVQYLKNDPEKLD-AFIMDKALLDYEVSIDA 857

  Fly   785 NCDLQVVGEEFSRKPYAIAVQQGSHLKDQFNNAILTLLNKRQLEKLKEKWWKNDEALAKCDKPE- 848
            :|.|..||:.|:.:.|.|.:...|.|....:..|....:...::.|.:||:|    :..|.|..
  Rat   858 DCKLLTVGKPFAIEGYGIGLPPNSPLTSNISELISQYKSHGFMDVLHDKWYK----VVPCGKRSF 918

  Fly   849 --DQSDGISIQNIGGVFIVIFVGIGMACITLV------------------FEYWWYRYRKNPRII 893
              .::..:.|::..|:|:::.:|.|::.:|.:                  .:||.:..::..|.:
  Rat   919 AVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHIVHRLLLPRIKNKSKLQYWLHTSQRFHRAL 983

  Fly   894 DVA--EANAERSNAADHPGKLVDGVILGHSGEKFEKSK-------------AALRPRFNQYP 940
            :.:  |....||..                 ::.|||:             .:|.||.|..|
  Rat   984 NTSFVEEKQPRSKT-----------------KRVEKSRWRRWTCKTEGDSELSLFPRSNLGP 1028

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	40..426	CDD:107378	76/428 (18%)
		PBP2_iGluR_putative	438..836	CDD:270435	103/445 (23%)
		Lig_chan	565..870	CDD:278489	67/313 (21%)
Grin3a	NP_612555.1	PBP1_iGluR_NMDA_NR3	30..497	CDD:107372	79/435 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	60..117
		ANF_receptor	127..469	CDD:279440	73/403 (18%)
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	102/443 (23%)
		Lig_chan	676..942	CDD:278489	67/314 (21%)
		PPP2CB binding site	951..987		3/35 (9%)
		GIT1-binding. /evidence=ECO:0000269\|PubMed:24297929	1082..1115
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350036
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830