DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir25a and T25E4.2

DIOPT Version :9

Sequence 1:	NP_001260049.1	Gene:	Ir25a / 33683	FlyBaseID:	FBgn0031634	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	NP_001364710.1	Gene:	T25E4.2 / 188897	WormBaseID:	WBGene00020804	Length:	455	Species:	Caenorhabditis elegans

Alignment Length:	447	Identity:	97/447 - (21%)
Similarity:	160/447 - (35%)	Gaps:	116/447 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   469 LINEIAAIVHFDYTIQEVEDGKFGNMDENGQWNGIVKKLMDKQADIGLGSMSVMAEREIVIDFTV 533
            |:|..|.||..|..|::..|     |..||            .|||.|.|.....:|...:|||.
Worm    47 LMNSTATIVQIDADIEQSID-----MVSNG------------SADITLVSARQTLDRMKKVDFTT 94

  Fly   534 P----YY--------DLVGITIMMQRPSSPSSLFKFLTVLETNVWLCILAA--YFFTSFLMWIFD 584
            |    ||        :|.....:|:       ||.:.|:.....:..|:.|  |.:|    |||.
Worm    95 PIGFVYYGYLVREIPELAVADYIMR-------LFDYDTLAILISFGLIIGALLYLYT----WIFG 148

  Fly   585 RWSPYSYQNNREKYKDDEEKREFNLKECLWFCMTSLTPQGGGEAPKNLSGRLVAATWWLFGFIII 649
                               .|..:|.:.::...:.:..|........:...::...|.|...:||
Worm   149 -------------------LRVRSLLDWMFISCSGIIHQFMFRISSPICALVLIGFWLLCCLVII 194

  Fly   650 ASYTANLAAFLTVS-RLDTPVESLDDL--AKQYKILYAPLNGSSAMTYFERMSNIEQMFYEIWKD 711
            ..|.|.|.:||.:| ...|...:||.:  |.::|       |.:.:        |::..|..:
Worm   195 TYYEAKLKSFLLLSHHRGTIFNTLDGVLEAAEHK-------GWTLV--------IQERGYTPY-- 242

  Fly   712 LSLNDSLTA-VERSKLAVWDYPVSDKYTKMWQAMQEAKLPATLDEAVARVRNSTAATGFAFLGD- 774
            |..|.|..| ::|.|..:          ....|..:|.|....|:.|          ||:.|..
Worm   243 LYCNPSQCARLDRLKSRI----------NFIGADDDANLLLGQDKHV----------GFSALASD 287

  Fly   775 --ATDIRYLQLTNCDLQVVGEEFSRKPYAIAVQQG-SHLKDQFNNAILTLLNKRQLEKLKEKWWK 836
              .|||.|....:..|.|..:..:.:..|.||.:. ..|:::||.|:  ...|.....::.::
Worm   288 LAETDITYFDYHSKILFVRDKIMAPEYLAYAVNKNVKGLREKFNRAV--AYTKSGYGTVRSRY-- 348

  Fly   837 NDEALAKCDKPEDQSDGISIQNIGGVFIVI----FVGIGMACITLVFEYWWYRYRKN 889
             ..:....:....||..|::..... ||.:    |:..|:|.|..:.|..::|..||
Worm   349 -IASFPSYNSVTSQSQTITVLQTSH-FIQLYKFCFIFYGIAIIVFILEIIFHRMTKN 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	40..426	CDD:107378
		PBP2_iGluR_putative	438..836	CDD:270435	84/388 (22%)
		Lig_chan	565..870	CDD:278489	62/318 (19%)
T25E4.2	NP_001364710.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900