Protein Alignment Ir25a and glr-6

DIOPT Version :10

• Sequence 1: NP_001260049.1
• Gene: Ir25a / 33683
• FlyBaseID: FBgn0031634
• Length: 947
• Species: Drosophila melanogaster
• Sequence 2: NP_741822.2
• Gene: glr-6 / 180955
• WormBaseID: WBGene00001617
• Length: 844
• Species: Caenorhabditis elegans
• Alignment Length: 920
• Identity: 220/920 - (23%)
• Similarity: 391/920 - (42%)
• Gaps: 150/920 - (16%)

  Fly    14 LLGFL---------SLLSSFSLEIAAQTTQNINVLFINE--VDNEPAAKAVEVVLTYLKKNIRYG 67
            ||.||         .|::|..||.:.:|..||.|..|||  |....|..........| ||....
 Worm     9 LLSFLGTGVSSIRIGLITSHHLEHSVRTAVNIIVPRINEQIVKTRGACFITHTSFIAL-KNSHED 72

  Fly    68 LSVQLDSIEANKSDAKVLLEAICNKYATSIEKKQTPHLILDTTKSGIASETVKSFTQALGLPTIS 132
            |:.::..: || |:..|::..:..:..:.||::.....||............|..|.....|::.
 Worm    73 LNTKICDL-AN-SEVSVIIGVVDRESGSIIEEQCAELNILFIHYYWTPGYQKKQQTSLNLYPSME 135

  Fly   133 ASYGQQGDLRQWR---------DLDEAKQKYLLQVMPPADIIPEAIRSIVIHMNITNAAILYDDS 188
            .|...:..:..||         :.|..||  |::.:...:..|..:|:..:..::...|:...|:
 Worm   136 YSQLMERLINLWRWDNFVYIYSNYDAPKQ--LIETLSRLEKSPALLRAHTLDDSMMATALALRDT 198

  Fly   189 FVMDH---KYKSLLQNIQTRHVITAIAKDGKREREEQIEKLRNLDINNFFILGTLQSIRMVLESV 250
            ...:.   |...:|..:.....:|..         :...||..:.::|:|::..|..:...|..
 Worm   199 CDRNRCWPKKNRVLIELSPNETLTFF---------DASLKLGMISVHNWFLITALDDLNDHLSQ- 253

  Fly   251 KPAYFERNFAWHAITQNEGEISSQRDNATIMFMK-PMAYTQYRDRLGLLRTTYNLNEEPQLSSAF 314
               |.........:|     :|.::.|...:.:| |..|.:|..::.....|      |....||
 Worm   254 ---YTHNGMRVSLLT-----VSKEKWNQNDLAIKLPDMYQEYLAKIPSNPRT------PFKDFAF 304

  Fly   315 YFDLALRSFLTIKEMLQSGAWPKDMEYLNCDDFQGGNTPQRNLDLRDYFTKITEPTSYGTFDLVT 379
            .||..|.:       .|:|    |...::|.|         |..::.:...|.:|     |..:|
 Worm   305 IFDSILLA-------CQAG----DRRIISCGD---------NEAVKKFKLPIVKP-----FKGLT 344

  Fly   380 QSTQPFNGHSFMK------FEMDINVLQIRGGSSVNSKSIGKWISGLNSELIVKDEEQMKNLTAD 438
            .... |||.|...      :||.|....:..|...::....|.::.|...:....|....::...
 Worm   345 GKIS-FNGTSDRSDSELHIWEMGITGAGLHTGIWKSTWEGSKELTMLAKNIPGTHEHYQASVRES 408

  Fly   439 TVYRIFTVVQAPFIMRDETAPKG---YKGYCIDLINEIAAIVHFDYTIQEVEDGKFGNMDENG-- 498
            ...::.::.:.|::: ::..|.|   ::|:|:||::::|.::||:||::.|:|.|:|.. :||
 Worm   409 RTLKVTSIHEKPYVI-EKIMPDGRIKHEGFCVDLLDKLAEMLHFNYTLKIVKDNKYGER-KNGTD 471

  Fly   499 QWNGIVKKLMDKQADIGLGSMSVMAEREIVIDFTVPYYDLVGITIMMQRPS--SPSSLFKFLTVL 561
            :|:|::.:::...||:.:..::|.|.|..|||||.|:..| ||:::|::|:  |.|||.:||..|
 Worm   472 EWDGMIGEILRGDADMAVAPITVTATRLEVIDFTDPFLQL-GISMLMRQPNPKSSSSLTRFLWPL 535

  Fly   562 ETNVWLCILAAYFFTSFLMWIFDRWSPYSYQNNREKYKDDEEKREFNLKECLWFCMTSLTPQGGG 626
            ..:||.....|...|:.|:.:....||            .|...||.::..:|:.:..|...|.|
 Worm   536 SASVWTFSAIATVITALLVTVAAVLSP------------KESTAEFKIQNSVWYLVCILLRAGSG 588

  Fly   627 EAPKNLSGRLVAATWWLFGFIIIASYTANLAAFLTVSRLDTPVESLDDLAKQYKILYAPLNGSSA 691
            ...:..:.||::|.||.|..::||.||||.||.|||.|...|..|.::|..|.:..:..:.|.|.
 Worm   589 YNCQAGATRLISAVWWSFTLVLIAQYTANFAALLTVDRKSMPFNSFEELGNQTEYNFGSILGGST 653

  Fly   692 MTYFERMSNIEQMFYEIWKDLSLNDSLTAVERSKLAVWDYPVSDKYTKMWQAMQEAKLPA---TL 753
            |.:| :.|.||                                 .:.::|:.||.|:..|   |.
 Worm   654 MQFF-KYSRIE---------------------------------TFRRLWERMQSAEPSAFVGTN 684

  Fly   754 DEAVARVRNSTAATGFAFLGDATDIRYLQLTNCDLQVVGE-EFSRKPYAIAVQQGSHLKDQFNNA 817
            .|.|.||.|..    :.||.::..:.|....||:|..||. ......|:||:.:||..:::....
 Worm   685 HEGVNRVLNEK----YVFLMESATLDYQVTQNCNLTRVGNVVLGSNGYSIALPKGSKWREKLTRQ 745

  Fly   818 ILTLLNKRQLEKLKEKWWKNDEALAKCDKPEDQSDGISIQNIGGVFIVIFVGIGMACITLVFEYW 882
            ||.|..|..:..||..|||..:...:..:|||....:..:|:.|:|:::.:|.|:..:..|.|:.
 Worm   746 ILDLNEKGIILMLKNNWWKKSQQECQSSEPEDLQTALGAENVYGLFLLLALGSGIGVLCAVLEHT 810

  Fly   883 WY-RYRKNPR 891
            .: .:.||.|
 Worm   811 HFIFFEKNKR 820

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	37..418	CDD:380606	75/401 (19%)
		PBP2_iGluR_putative	438..836	CDD:270435	117/408 (29%)
glr-6	NP_741822.2	PBP1_iGluR_non_NMDA-like	21..394	CDD:380591	83/427 (19%)
		PBP2_iGluR_Kainate	409..764	CDD:270432	117/407 (29%)