DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir25a and glr-7

DIOPT Version :9

Sequence 1:	NP_001260049.1	Gene:	Ir25a / 33683	FlyBaseID:	FBgn0031634	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	NP_001337310.1	Gene:	glr-7 / 180547	WormBaseID:	WBGene00001618	Length:	885	Species:	Caenorhabditis elegans

Alignment Length:	909	Identity:	383/909 - (42%)
Similarity:	538/909 - (59%)	Gaps:	99/909 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 VQLDSIEANKSDAKVLLEAICNKYATSIEKKQTPHLILDTTKSGIASETVKSFTQALGLPTISAS 134
            :.|:..:.|.|..   :.::|::..       ....::...:|..:...|....:...:|||
Worm    12 ISLERYDFNDSSD---INSLCDQMV-------NVSFVISVCRSNDSISLVAELARISQVPTI--- 63

  Fly   135 YGQQGDLRQWR-DLD--------EAKQKYLLQVMPPADIIPEAIRSIVIHMNIT-NAAILYDDSF 189
               |.||..|. .|:        .:...|...|:... :....|..|...:||| |:.:|||:.:
Worm    64 ---QVDLNYWSLPLNFNGTSVPTISSPSYTTMVLSTL-VFQNVITDIFADLNITPNSTVLYDNMY 124

  Fly   190 VMD----HKYKSLLQNIQTRHVITAIAKDGKREREEQIEKLRNLDINNFFILGTLQSI-RMVLES 249
            ..|    ....|:|..|:...:.|.:.:     ...||.:||...||:..::...::: |..||:
Worm   125 PPDFTAWRDAFSVLPGIRFVPMETTVLR-----MRAQITQLRMASINSLILVAKTENVERFTLEA 184

  Fly   250 VKPAYF--ERNFAWHAITQNEGEISSQRDNATIMF-MKPMAYTQ-----------YRDRLGLLRT 300
               |.|  :|.|..:.:|::..........:..|| ::|....:           :|:.:| |..
Worm   185 ---ADFIEQRVFNTYVLTKDITAFKCDSCESAFMFWLRPFPVGKLMEIRDLDDYLFRNEIG-LEL 245

  Fly   301 TYNLNEEPQLSSAFYFDLALRSFLTIKEMLQSGAWPKDMEYLNCDDFQGGNTPQRNLDLRDYFTK 365
            .|::|....|:.|||.::...:|.||:.|   .|....:....|.  .|.:.|.....:||..
Worm   246 DYSINGWDSLNVAFYMNVMGYAFETIRTM---NATFDVLPTFTCQ--TGPSEPNITTTVRDII-- 303

  Fly   366 ITEPT-SYGTFDLVTQSTQPFNGHSFMKFEMDINVLQIRGG----SSVNSKSIGKW--ISGLNSE 423
            :.:|. .||.:   |::     |.:....::::.:.:|...    .::.:|.:|.|  ||.| |.
Worm   304 LNDPAHEYGNY---TEA-----GLNMFFQDVEVRIYKIDRDRDHEDALFNKEVGVWSPISKL-SV 359

  Fly   424 LIVKDEEQMKNLTADTVYRIFTVVQAPFIMRDETAPKGYKGYCIDLINEIAAIVHFDYTIQEVED 488
            :....:..::||   .::|:.|::|.||:.|.......|:||||||||.|...|:|.|||.||||
Worm   360 MYGTLQVDVRNL---NIFRVVTLIQPPFVQRTGDPDTPYEGYCIDLINMIQVEVNFTYTIYEVED 421

  Fly   489 GKFGNMDENGQWNGIVKKLMDKQADIGLGSMSVMAEREIVIDFTVPYYDLVGITIMMQRPSSPSS 553
            |.||.||:||.|||::..|:...|||.|..:|||||||..:|||||||||||.||:|::.....|
Worm   422 GSFGTMDDNGNWNGLIGALVSGSADIALAPLSVMAERENDVDFTVPYYDLVGTTILMKKADVEYS 486

  Fly   554 LFKFLTVLETNVWLCILAAYFFTSFLMWIFDRWSPYSYQNNREKYKDDEEKREFNLKECLWFCMT 618
            ||||:.|||..|||||:|||.|||.|:|||||:||||:.||:|:|::|.|||:|:||||||||||
Worm   487 LFKFMKVLEWPVWLCIVAAYLFTSILLWIFDRFSPYSFTNNKERYQNDIEKRQFSLKECLWFCMT 551

  Fly   619 SLTPQGGGEAPKNLSGRLVAATWWLFGFIIIASYTANLAAFLTVSRLDTPVESLDDLAKQYKILY 683
            |||||||||||||:|||||||||||||||||||||||||||||||||:.|:.|||||||||||.|
Worm   552 SLTPQGGGEAPKNISGRLVAATWWLFGFIIIASYTANLAAFLTVSRLEQPISSLDDLAKQYKIEY 616

  Fly   684 APLNGSSAMTYFERMSNIEQMFYEIWKDLSLNDSLTAVERSKLAVWDYPVSDKYTKMWQAMQEAK 748
            ||:.||::.|||.||:.||:.||.:||::|||:|::..:|:||||||||||||:|.||:.|||:|
Worm   617 APIKGSASETYFRRMAEIEETFYNMWKEMSLNESMSPRDRAKLAVWDYPVSDKFTNMWRYMQESK 681

  Fly   749 LPATLDEAVARVRNSTAATGFAFLGDATDIRYLQLTNCDLQVVGEEFSRKPYAIAVQQGSHLKDQ 813
            ||..:|.||.||.||  ..||||:||||:|:|..||||:||.||.||||||||||||.|..|||:
Worm   682 LPVNMDTAVDRVLNS--VDGFAFIGDATEIKYAALTNCNLQQVGTEFSRKPYAIAVQSGHILKDK 744

  Fly   814 FNNAILTLLNKRQLEKLKEKWWKNDEALAKCDKPEDQSDGISIQNIGGVFIVIFVGIGMACITLV 878
            .::|||.|||:|:||.||||||.::.....|....|:||||||||||||||||..||.::.:||.
Worm   745 ISSAILMLLNERRLETLKEKWWTDNPNKVSCPDSSDESDGISIQNIGGVFIVILAGIALSIVTLA 809

  Fly   879 FEYWWYRYR------KNPRIIDVAEA-----NAERSNAA--DHPGKLVDGVILGHSGEKFEKSK 929
            |||::|:.:      |....:::.::     |...:|..  |.| ||.:|.  ..:|..|.::|
Worm   810 FEYYYYKRKARKAAEKEQEELEMKQSQQVVPNGFHTNGVKQDAP-KLTNGT--KTNGNTFRRTK 870

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	40..426	CDD:107378	79/391 (20%)
		PBP2_iGluR_putative	438..836	CDD:270435	264/397 (66%)
		Lig_chan	565..870	CDD:278489	214/304 (70%)
glr-7	NP_001337310.1	Periplasmic_Binding_Protein_Type_1	<102..>220	CDD:324556	30/125 (24%)
glr-7	NP_001337310.1	PBP2_iGluR_putative	373..767	CDD:270435	264/395 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160164658
Domainoid	1	1.000	456	1.000	Domainoid score	I249
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H15105
Inparanoid	1	1.050	630	1.000	Inparanoid score	I463
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		oto18299
orthoMCL	1	0.900	-	-		OOG6_119364
Panther	1	1.100	-	-	LDO	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.750