DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir25a and nmr-2

DIOPT Version :9

Sequence 1:	NP_001260049.1	Gene:	Ir25a / 33683	FlyBaseID:	FBgn0031634	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	NP_001256640.1	Gene:	nmr-2 / 180002	WormBaseID:	WBGene00003775	Length:	990	Species:	Caenorhabditis elegans

Alignment Length:	1004	Identity:	225/1004 - (22%)
Similarity:	376/1004 - (37%)	Gaps:	261/1004 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 KVLLEAICNKYATSIEKKQTPHLILDTTKSGIASETVKSFTQA----------LGLPTI-----S 132
            |.:|:.:||...::     ...||:..|    ||||..|.|.|          .|:|.|     :
Worm   102 KEVLDCLCNNVTSN-----NVALIIFVT----ASETYDSTTAAEQYFLTAASYTGIPIIAWNADN 157

  Fly   133 ASYGQQGDLRQWRDLDEAKQKYLLQVMPPADIIPEAIRSIVIHMN-----ITNAAILYDDSFVMD 192
            |.:..:.||..:|         ::|:.||.:....|:.:::...|     :..:.:..:|.||..
Worm   158 AGFTFENDLGPYR---------IIQMAPPIEHQARAMLALLRRYNWPKFGVVTSEMAGNDRFVTA 213

  Fly   193 HKYK-SLLQNIQTRHVITAIAKDGKREREEQIEKLRNLDINNFFIL---------GTLQSIRMVL 247
            .:.: .|..|..|:..:...:....:...:...||.::..|...|:         ||:.|....:
Worm   214 IREELELFSNKSTKFEMIHFSHMNTKNDTDVDLKLADVKKNQAKIILLYANAAQAGTIFSHAEKM 278

  Fly   248 ESVKPAYFERNFAWHAITQNEGEISSQRDNATIMFMKPMAYTQYRDRLGLLRTTYN--------- 303
            :.:...|.     |         |.:|....|...:|..|      :.|:|...::
Worm   279 DMIGEKYL-----W---------IGTQSVKGTQTTVKAPA------QAGMLCVNFHTVSNAMFAP 323

  Fly   304 --------LNEEPQLSSAFYFDL------ALRSFLTIKEMLQSGAWPKD---MEYLNCDDFQGGN 351
                    :...|:|..|....|      :|:|.::.|.......|...   .|::.. .|..||
Worm   324 RDDILPLIIQLAPKLFGAALLQLRPNEMFSLKSNVSCKSEDGDPYWDNGKYIYEHMKA-AFVKGN 387

  Fly   352 TPQRNLDLRDYFTKITEPTSYGTFDLVTQSTQPF---NGHS--FMKFE----MDINVLQIRGGSS 407
                                            ||   :||.  |..||    :..::||| ....
Worm   388 --------------------------------PFHVDDGHDSFFYTFEKTGRLRNSILQI-SNLR 419

  Fly   408 VNSKSIGKWIS-GL--NSELIVKDEE---QMKNL---TADTVY-RIFTVVQAPFIMRDETAPKGY 462
            .|||....|.. |:  |:||.:.|.:   :..|.   .||..: ::.|:.:.|||...:..|...
Worm   420 TNSKGEKTWEKVGIFTNNELKMADVQWPGEKANPPQGAADKFHVKVVTLHEPPFIAVSDVDPDTQ 484

  Fly   463 K---------------------------------GYCIDLINEIAAIVHFDYTIQEVEDGKFGNM 494
            |                                 |||:||:|::|..:.|.||:.:|.|.|:|..
Worm   485 KCPGNQGSICDWGDVEYTDGAGVKKNRTLLKCCSGYCVDLLNKLANDIGFTYTLYKVRDEKWGLK 549

  Fly   495 DENGQWNGIVKKLMDKQADIGLGSMSVMAEREIVIDFTVPYYDLVGITIMMQRPSSPSSLFKFLT 559
            .||| |||::..||..:||:.:.|:.:.:||...|||::|:.| .||:|:::..|...|...||.
Worm   550 TENG-WNGLIADLMHNKADMCVTSLKLNSERARDIDFSLPFLD-TGISIIVKIRSGVLSPTAFLE 612

  Fly   560 VLETNVWLCIL-AAYFFTSFLMWIFDRWSPYSYQNNREKYKDDEEKREFNLKECLWFCMTSL-TP 622
            ..|.:.|:.|| ......:..:::|:..||||:  |.:||...|.|  |:|....|....:| :.
Worm   613 PFEYSTWVIILFVCIHVAAISIFLFEWVSPYSF--NMQKYPPPEHK--FSLFRSYWLVWATLFSA 673

  Fly   623 QGGGEAPKNLSGRLVAATWWLFGFIIIASYTANLAAFLTVSRLDTPVESLDDLAKQYKILYAPLN 687
            ....:.||:...||:|..|..||...:|.||||||||:..                 ::.|..|:
Worm   674 SVSTDVPKSTVSRLMALVWAAFGLTFLAVYTANLAAFMIT-----------------RVQYYDLS 721

  Fly   688 G-SSAMTYFE-------RMSNIEQMFYEIWKDLSLNDSLTAVERSKLAVWDYPVSDKYTKMWQAM 744
            | ...|..|.       |...::.           .::...::|:...:.:|...:||.:|
Worm   722 GIHDPMLNFPHDQKPPFRFGTVDG-----------GNTHETMKRNWHKMHEYVKHNKYFRM---- 771

  Fly   745 QEAKLPATLDEAVARVRNSTAATGFAFLGDATDIRYL--QLTNCDLQVVGEEFSRKPYAIAVQQG 807
                   .:...:..|:|....   ||:.||..:.|.  :..||.|..||:..|...|.|...:.
Worm   772 -------NISAGIEAVKNEELD---AFIYDAVVLDYWAGKDANCALMTVGKWASMTGYGIGFPKN 826

  Fly   808 SHLKDQFNNAILTLLNKRQLEKLKEKWWKNDEALAKCDKPEDQSDGISIQNIGGVFIVIFVGIGM 872
            |......|:.:|....|..||:|:..|...  |.......:.||..:.|:|....|:::..||.:
Worm   827 SPHTSLVNHYMLQYQQKGDLERLQNFWLTG--ACTPDSHSQTQSAPLGIENFLSAFVLLAGGIIV 889

  Fly   873 ACITLVFEYWWYRYRKNP----------RIIDVAEANA----ERSNAADHPGKLVDGVILGHSGE 923
            :.|.|.||:.:..:.:.|          .||.:|...:    |..:...........:...:|.:
Worm   890 SVIVLGFEHIYCMHLRKPLQKIDPNGWCGIISMAMGKSLTFTEAVDRVQEWRSRTQSLASTNSPQ 954

  Fly   924 KFEKSKAALRPR---FNQ--YPATFKPRF 947
            ...:..|.|||.   |||  .|....|||
Worm   955 LKRRRSANLRPTEEPFNQDLNPPRRSPRF 983

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	40..426	CDD:107378	78/410 (19%)
		PBP2_iGluR_putative	438..836	CDD:270435	115/443 (26%)
		Lig_chan	565..870	CDD:278489	74/316 (23%)
nmr-2	NP_001256640.1	rSAM_ocin_1	<54..>108	CDD:274893	2/5 (40%)
		Periplasmic_Binding_Protein_type1	102..443	CDD:385651	78/412 (19%)
		Periplasmic_Binding_Protein_Type_2	460..860	CDD:389745	115/449 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910