DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir25a and glr-5

DIOPT Version :9

Sequence 1:	NP_001260049.1	Gene:	Ir25a / 33683	FlyBaseID:	FBgn0031634	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	NP_505244.1	Gene:	glr-5 / 179251	WormBaseID:	WBGene00001616	Length:	932	Species:	Caenorhabditis elegans

Alignment Length:	960	Identity:	225/960 - (23%)
Similarity:	406/960 - (42%)	Gaps:	193/960 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 WLLGFLSLLSSFSLEIAAQTTQNINVLFINEVDNEPAAKAVEVVLTYLKKNIRYG---LSVQ--- 71
            ::....::|..||....|   ..|..:| .|.::.....||...:.:|.:...||   |.::
Worm     7 YIFSIFTILHVFSTSCIA---YKIGAIF-REREDAHIEAAVRYSVEWLSQRGIYGDIDLVIEYID 67

  Fly    72 -LDSIEANKSDAKVLLEAICNKYATSIEKKQTPHLI--LDTTKSGIASETVKSFTQALGLPTISA 133
             ||..:|.|...|:|               :..|::  |..:.:.:.:: ::..|..|.:|.::|
Worm    68 VLDHYDAIKKACKML---------------EKDHIVALLGGSHAALNAQ-LERITDDLDIPFLTA 116

  Fly   134 SYGQQGDLRQWRDLDEAKQKYLLQVMPPADIIPEAIRSIVIHMNITNAAILYDDSFVMDHKYKSL 198
            .    .|||  .|:.::|..:.     |...:.||:..:..|.......::|:.    |.:.:.|
Worm   117 I----DDLR--TDMGKSKIDFW-----PRPQLFEAVVDMFTHWRWNRIVLVYEG----DERIRRL 166

  Fly   199 LQNIQT------RHVITAIAKDG---KRERE-EQIEKLRNL---DINNF--------------FI 236
            .|.:::      |..:..: .||   |..|: :::|:.|.|   |.:.|              |:
Worm   167 EQLLESEEYASIRFYLIKV-HDGDYMKAARQVKELEECRLLHKKDCSEFSRLLVDMNPEHTYTFL 230

  Fly   237 LGTLQSIRMVLESVKPAYFERNFAWHAITQNEGEISSQ-----RDNATIMFMKPMA-----YTQY 291
            |.:||   |.|..:|        .|..:|..  |:|:.     |.|.. .|:.|..     .|:.
Worm   231 LASLQ---MGLIELK--------HWFLLTNM--ELSTMDMELFRYNHA-RFISPYPVDSTFLTEN 281

  Fly   292 RDRLGLLRTTYNLNEE-----------PQLSSAFYFDLALRSFLTIKEMLQSGAWPKDMEYLNCD 345
            ||.........::.|:           ..:.:.|.|| |:.:|..:...|.|.....|:....|
Worm   282 RDAFNFSHFKEHITEKWAMKTDNSRNLKMMEAVFTFD-AVYAFANVFNELSSHMQMNDVPQTLC- 344

  Fly   346 DFQGGNTPQRNLDLRDYFTKITEPTSYGTFDLVTQSTQPFNGHSF-MKFEMDINVLQIRGGSSVN 409
                 ....||.....:...:.:...:.....::...:..|||.. ..|.|.|.:|    |.|..
Worm   345 -----RKSSRNSRKYQHGRSLIDNIVHNDLHGLSGDLRRLNGHPLKSNFSMRIQLL----GYSGR 400

  Fly   410 SKSIGKWISGLNSELIVKDEEQ---MKNL-TADTV---YRIFTVVQAPFIMRDET-----APKGY 462
            ...||.|....|..:.:..:.:   .:|: .:|.:   :|:.|:::.|::|..:.     |...:
Worm   401 LDDIGFWEPATNVHVNMSGDSKAQLQRNVQVSDELKPHFRVTTIMERPYVMLKKNHYELDANSKF 465

  Fly   463 KGYCIDLINEIAAIVHFDYTIQEVEDGKFGNMDE--NGQWNGIVKKLMDKQADIGLGSMSVMAER 525
            :|:||||:.|::..:.|.|||..|:|||:|| |:  ||.|:|::.:::..:|::.:..::|...|
Worm   466 EGFCIDLLAELSKDLGFTYTIHAVKDGKYGN-DKYGNGSWDGMMGEILRGEAEMAVAPLTVNYRR 529

  Fly   526 EIVIDFTVPYYDLVGITIMMQRPSSPS-SLFKFLTVLETNVWLCILAAYFFTSFLMWIFDRWSPY 589
            ...:|||.|:..| ||:|:.:.|.... .||.||..|...:|..|..:....:..|:.....:||
Worm   530 SEAVDFTKPFLSL-GISILYKVPDDQQPDLFSFLNPLSWQIWTAIATSIITVTLGMYFVANVTPY 593

  Fly   590 SYQNN-----------REKYKDDEE-----KREFNLKECLWFCMTSLTPQGGGEAPKNLSGRLVA 638
            .:..|           ...:..::|     ...::....:|:.::::...|....|:.:|.||:.
Worm   594 EWNLNFSCCTAHEPHPAAAFATNQEAPIVMSNNYSFWNTVWYVLSTMLKGGCDFGPRAVSTRLLG 658

  Fly   639 ATWWLFGFIIIASYTANLAAFLTVSRLDTPVESLDDLAKQYKILYAPLNGSSAMTYFERMSNIEQ 703
            .|||:|..:||::|||||||.|||||...|:::|||||.|..|.|..:.|.|.|.:|
Worm   659 GTWWVFYLVIISAYTANLAAVLTVSRPYIPIKNLDDLANQTTISYGTIRGGSTMQFF-------- 715

  Fly   704 MFYEIWKDLSLNDSLTAVERSKLAVWDYPVSDKYTKMWQAMQEAKLPATLD-EAVARVRNSTAAT 767
                              :.|::|.        :.||||.|::..:..|.: :.|.|    ..:.
Worm   716 ------------------QESRIAA--------HVKMWQYMKDKDVFVTSNGKGVER----ALSM 750

  Fly   768 GFAFLGDATDIRYLQLTNCDLQVVGEEFSRKPYAIAVQQGSHLKDQFNNAILTLLNKRQLEKLKE 832
            .:|:|.::|.:.|....||:|..:|.....|.|.||:.:.|...|:.:..||....:..:|..|.
Worm   751 NYAYLMESTSLEYETQQNCNLTQIGGVLGSKGYGIALAKKSEWTDRISRQILLYAKRGIIEMKKT 815

  Fly   833 KWWKNDEALAKCDKPEDQSD--GISIQNIGGVFIVIFVGIGMACITLVFE 880
            |||::..|.........:.|  .:|:.|:.|:||.:.|||.:|.|.::||
Worm   816 KWWRSKGAACASTASAVKHDRFALSMYNVAGLFITLGVGIVLAAIVVIFE 865

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	40..426	CDD:107378	86/443 (19%)
		PBP2_iGluR_putative	438..836	CDD:270435	118/425 (28%)
		Lig_chan	565..870	CDD:278489	83/323 (26%)
glr-5	NP_505244.1	PBP1_iGluR_delta_like	26..418	CDD:107376	87/449 (19%)
		ANF_receptor	38..377	CDD:279440	71/391 (18%)
		PBP2_iGluR_Kainate	438..819	CDD:270432	117/420 (28%)
		Lig_chan	568..855	CDD:278489	83/324 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810