DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir25a and glr-4

DIOPT Version :9

Sequence 1:	NP_001260049.1	Gene:	Ir25a / 33683	FlyBaseID:	FBgn0031634	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	NP_001254126.1	Gene:	glr-4 / 174258	WormBaseID:	WBGene00001615	Length:	951	Species:	Caenorhabditis elegans

Alignment Length:	959	Identity:	251/959 - (26%)
Similarity:	405/959 - (42%)	Gaps:	204/959 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 LSSFSLEIAAQTTQNINVLFINEVDNEPAAKAVEVVLTYLKKNIRYGLSVQLDSIEANKSDAKVL 85
            :..::.|..|.|....:::.....||....:..|:        ::.|:...:.|.|.::.|:: |
Worm    49 IDRWNTEHGAHTQIKFSIVSPIRYDNNYEERMCEI--------MQQGIVAVVLSNEESEQDSQ-L 104

  Fly    86 LEAICNKY--------ATSIEKKQTPHLILDTTKSGIASETVKSFTQALGLPTISASYGQQGDLR 142
            ::::|:.:        :||:....:..:.|.....|..:.....|..::.......:|....||.
Worm   105 IKSMCHYFNIPCLSLQSTSLRDSVSDFVTLLGPSRGAGARATSEFLDSMRWTGFLLAYQHGSDLE 169

  Fly   143 QWRDLDEAKQKYLLQVMPPADIIPEAIRSIVIHMNITNAAILYDDSFVMDHKYKSLLQNIQTRHV 207
            ....|.:.||           |:....|.  ||:.|.......||       |:..|:.::||..
Worm   170 DLSPLMQYKQ-----------IVDTGGRR--IHIKIRRLPNNTDD-------YEPFLKYVKTRLK 214

  Fly   208 ITAIAKDGKREREEQIEKLRNLDINNFFILGTLQSIRMVLESVKPAYFERNFAWHAITQNEGEIS 272
            .|.|.                :..||..:|..|......|...:|.:.      :..|..  ::|
Worm   215 QTNII----------------IHSNNITVLYNLLQQARGLNMAEPPFS------YVFTNT--DLS 255

  Fly   273 SQRDNATIMFMKPMAYTQYRDRLGLLRTTYNLNEEPQLSSAFYFDLALRS------FLTIKEMLQ 331
            ...|     |:..|....:...:..|:...|   :|.:.:    .|||.|      .::|..|.:
Worm   256 LLED-----FLNNMYGASFHCNITGLQLVKN---DPMMKT----QLALTSEAVYVVGMSIYRMRE 308

  Fly   332 SGAWPKDMEYLNCD------DFQGGNTPQRNLDLRDYFTKITEPTSYGTFDLVTQSTQPFNGHSF 390
            .|..|:....: ||      |.:..|...|.|.||:..|...:..|.|..|
Worm   309 LGHAPRQSSIM-CDSHDIWSDGRIMNEGIRKLKLRNQLTGDVQFKSNGERD-------------- 358

  Fly   391 MKFEMDINVLQIRGGSSVNSK--SIGKWIS--GLNSEL---------IVKDEEQMKNLTADTVYR 442
                 ||   ...|...:||:  .:|.|..  |.|.:.         |..|.|.::.|.    .|
Worm   359 -----DI---MYHGVGRINSQFVKLGNWSEKRGWNFDSRYANRWEFDIDPDSEDLEGLH----LR 411

  Fly   443 IFTVVQAPFIMRDETAPKGYKGYCIDLINEIAAIVHFDYTIQEVEDGKFGNMDENGQWNGIVKKL 507
            :...::.||:::  |....|:|:||||:||:..::.|:|||.||:||.:|..||:|:||||:..|
Worm   412 VVVYLEEPFVIK--TGENQYEGFCIDLLNEMTQVLKFNYTIIEVQDGTYGIEDESGRWNGIIGAL 474

  Fly   508 MDKQADIGLGSMSVMAEREIVIDFTVPYYDLVGITIMMQRPSSPS---SLFKFLTVLETNVWLCI 569
            ...:||:.|.::::...|..|:|||:|:..| ||:|::.|.|..:   ||:.||..|...||:.:
Worm   475 QRHEADLSLSAVTITYSRAEVVDFTLPFMHL-GISILLARTSEETDKGSLWTFLEPLSLTVWISL 538

  Fly   570 LAAYFFTSFLMWIFDRWSPYSYQN-NREKYKDDE----EKREFNLKECLWFCMTSLTPQGGGEAP 629
            |.:|...|:.|.|..::|||.:.| .|...:|.|    :|.:|.:....||.|.||..||....|
Worm   539 LISYCIVSYSMHILAKFSPYEWYNLERIDERDFENIKNQKNQFTVLNSFWFTMGSLMQQGSDVIP 603

  Fly   630 KNLSGRLVAATWWLFGFIIIASYTANLAAFLTVSRLDTPVESLDDLAKQYKILYAPLNGSSAMTY 694
            :..:.||:|..||:|..|||:||||.|||||||.|:.||:||..|||.|.||.|..|...|.|.:
Worm   604 RAAATRLIAVVWWMFTQIIISSYTAQLAAFLTVERMSTPIESTQDLANQQKIRYGVLKSGSTMDF 668

  Fly   695 FERMSNIEQMFYEIWKDLSLNDSLTAVERSKLAVWDYPVSDKYTKMWQAMQEAKLPATL----DE 755
            |                          ..||:.:        |.:||..| |:..|...    .|
Worm   669 F--------------------------RESKIPM--------YERMWSVM-ESSSPGVFVNSSRE 698

  Fly   756 AVARVRNSTAATGFAFLGDATDIRYLQLTNCDLQVVGEEFSRKPYAIAVQQGSHLKDQFNNAILT 820
            .:|||::.    |:|::.:::.:.|....:|:||.:|.....|.|.||:.:||.|:|..:..:|.
Worm   699 GIARVKSG----GYAYMMESSMLEYYLERDCELQSIGGLLDSKGYGIALPKGSPLRDILSRTVLQ 759

  Fly   821 LLNKRQLEKLKEKWWKNDEALAKC-DKPEDQSDGISIQNIGGVFIVIFVGI--------GMACI- 875
            |..:..||.||.|||::......| ..|.:::.....|||.|:|.|:..|:        |..||
Worm   760 LQERTILEALKNKWWRDRREGPSCGPPPSEKATNSKPQNIFGIFYVLLTGLIVAFLLACGEYCIE 824

  Fly   876 ----------TLVFEYW-WYRYRKNPRIIDVAEANAERSNAADHPGKLV 913
                      |:|.::. |||...|    |..:.:..|:...|..|:.|
Worm   825 SRHEAFRLKLTIVGKFMDWYRGNSN----DSKQRSKLRNMQLDTAGQEV 869

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	40..426	CDD:107378	76/418 (18%)
		PBP2_iGluR_putative	438..836	CDD:270435	144/409 (35%)
		Lig_chan	565..870	CDD:278489	104/314 (33%)
glr-4	NP_001254126.1	PBP1_iGluR_Kainate	30..385	CDD:107377	78/423 (18%)
		ANF_receptor	45..365	CDD:279440	72/403 (18%)
		Periplasmic_Binding_Protein_Type_2	410..775	CDD:304360	144/406 (35%)
		Lig_chan	533..810	CDD:278489	104/315 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910