Protein Alignment Ir25a and Grin3b

DIOPT Version :10

• Sequence 1: NP_001260049.1
• Gene: Ir25a / 33683
• FlyBaseID: FBgn0031634
• Length: 947
• Species: Drosophila melanogaster
• Sequence 2: NP_579842.2
• Gene: Grin3b / 170796
• RGDID: 621705
• Length: 1002
• Species: Rattus norvegicus
• Alignment Length: 1031
• Identity: 201/1031 - (19%)
• Similarity: 352/1031 - (34%)
• Gaps: 346/1031 - (33%)

  Fly    48 PAAKA-VEVVLTYLKKNIRYGLSVQLDSIEANKSDAKVLLEAICNKYA-----TSIE-KKQTPHL 105
            |||:| |...|......:.:.||::|.::.:...|...|...:|...|     .||. .:..|.|
  Rat    49 PAARARVLAALATPAPRLPHNLSLELVAVASPTRDPASLARGLCQVLAPPGVVASIAFPEARPEL 113

  Fly   106 -----ILDTTKSGIASETVKSFTQALGLPTISASYGQQGDLRQWRDLDEAKQKYLLQVMPPADII 165
                 :...|::.:.|...:....|||.||   .:..|.|   |..              |.:.|
  Rat   114 RLLQFLAAATETPVVSVLRREVRTALGAPT---PFHLQLD---WAS--------------PLETI 158

  Fly   166 PEAIRSIVIHMNITNAAILYDDSFVMDH-KYKSLLQNIQTRHVITAIAKDGKREREEQIEKLRNL 229
            .:.:.|:|      .|....|.:.|:.. :....|..:.|.|...|         .:.:..|..|
  Rat   159 LDVLVSLV------RAHAWEDIALVLCRVRDPGSLVTLWTNHASQA---------PKFVLDLSRL 208

  Fly   230 DINN------FFILGTLQS-----------------IRMVLESVKPAYFERNFAWHAITQNEGEI 271
            |..|      ..:||.|:.                 ...|||:..|..     .|
  Rat   209 DSRNDSLRAGLALLGALEGGGTPVPAAVLLGCSTARAHEVLEAAPPGP-----QW---------- 258

  Fly   272 SSQRDNATIMFMKPMAYTQYRDRLGLLRTTYNLNEEPQLS-SAFYFDL------ALRSFLTI--- 326
                     :...|:. .:.....||......|.|..|.| .|...|:      ||.|...:
  Rat   259 ---------LLGTPLP-AEALPTTGLPPGVLALGETEQHSLEAVVHDMVELVAQALSSMALVHPE 313

  Fly   327 KEMLQSGAWPKDMEYLNCDDFQGGNTPQRNLDLRDYFTKITEPTSYGTFDLVTQSTQPFNGHSFM 391
            :.:|.:        .:||||.:.|.               :|.|                |.:..
  Rat   314 RALLPA--------VVNCDDLKTGG---------------SEAT----------------GRTLA 339

  Fly   392 KFEMDINVLQIRGGSSVNSKSIGKWISGLNSELIVKDEEQMKNLTADTV---------------- 440
            :|         .|.:|...::...|::| :|::.|....::.:|..|.:
  Rat   340 RF---------LGNTSFQGRTGAVWVTG-SSQVHVSRHFKVWSLRRDPLGAPAWATVGSWQDGQL 394

  Fly   441 ----------------------YRIFTVVQAPFIM-----RDETAPKGY---------------- 462
                                  .|:.|:|:.||:.     .|...|.|.
  Rat   395 DFQPGAAALRVPSPSGTQARPKLRVVTLVEHPFVFTRESDEDGQCPAGQLCLDPGTNDSARLDAL 459

  Fly   463 -----------------KGYCIDLINEIAAIVHFDYTIQEVEDGKFGNMDENGQWNGIVKKLMDK 510
                             .||||||:..:|..:.||:.:..|.|||:|.: .:|:|.|:|..|:..
  Rat   460 FAALVNGSVPRTLRRCCYGYCIDLLERLAEDLAFDFELYIVGDGKYGAL-RDGRWTGLVGDLLAG 523

  Fly   511 QADIGLGSMSVMAEREIVIDFTVPYYDLVGITIMMQRPSSPSSLFKFLTVLETNVWLCILAAYFF 575
            :|.:.:.|.|:.:.|..|:|||.|::. ..:.||::...:.|.:..|:..|..::|:.:.||...
  Rat   524 RAHMAVTSFSINSARSQVVDFTSPFFS-TSLGIMVRTRDTASPIGAFMWPLHWSMWVGVFAALHL 587

  Fly   576 TSFLMWIFDRWSPYSYQ---NNREKYKDDEEKREFNLKECLWFCMTSLTPQG-GGEAPKNLSGRL 636
            |:..:.:::..|||...   .||...        |:....|..|...|..:. ..:.||..:||.
  Rat   588 TALFLTLYEWRSPYGLTPRGRNRGTV--------FSYSSALNLCYAILFGRTVSSKTPKCPTGRF 644

  Fly   637 VAATWWLFGFIIIASYTANLAAFLTVSRLDTPVESLDDLAKQYKILYAPLNGSSAMTYFERMSNI 701
            :...|.:|..::::||||||||.:...:.                             ||.:|.|
  Rat   645 LMNLWAIFCLLVLSSYTANLAAVMVGDKT-----------------------------FEELSGI 680

  Fly   702 EQMFYEIWKDLSLNDSLTAVERSKLAVWDYPVSD-KYTKMWQAMQEAKLPATLDEAVARVRNSTA 765
            .        |..|:               :|... ::..:|::..||.:.|:..|..|.:|..:|
  Rat   681 H--------DPKLH---------------HPSQGFRFGTVWESSAEAYIKASFPEMHAHMRRHSA 722

  Fly   766 AT---GF-----------AFLGDATDIRY-LQL-TNCDLQVVGEEFSRKPYAIAVQQGSHLKDQF 814
            .|   |.           ||:.|.:.:.| :.: .:|.|..||:.|:.:.|.|.:.|.|.|....
  Rat   723 PTTPHGVAMLTSDPPKLNAFIMDKSLLDYEVSIDADCKLLTVGKPFAIEGYGIGLPQNSPLTSNL 787

  Fly   815 NNAILTLLNKRQLEKLKEKWWKNDEALAKCDK---PEDQSDGISIQNIGGVFIVIFVGIGMACIT 876
            :..|....:...::.|.:||:|    :..|.|   ...::..:.:.:..|:|:::.:|:|.|.:|
  Rat   788 SEFISRYKSSGFIDLLHDKWYK----MVPCGKRVFAVTETLQMGVYHFSGLFVLLCLGLGSALLT 848

  Fly   877 LV------------------FEYWWYRYRKNPRIIDVA-------EANAERSNAAD 907
            .:                  .:||.:..:|..|.::..       .|..|||...|
  Rat   849 SLGEHVFYRLVLPRIRRGNKLQYWLHTSQKIHRALNTGPPEGQQERAEQERSGPKD 904

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	37..418	CDD:380606	75/415 (18%)
		PBP2_iGluR_putative	438..836	CDD:270435	104/494 (21%)
Grin3b	NP_579842.2	PBP1_iGluR_NMDA_NR3	19..401	CDD:380600	80/460 (17%)
		PBP2_iGluR_NMDA_Nr3	414..808	CDD:270438	102/455 (22%)
		Lig_chan	574..841	CDD:459656	67/330 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	882..910		5/23 (22%)
		Involved in the trafficking and surface expression of NMDARs. /evidence=ECO:0000250|UniProtKB:Q91ZU9	951..984