Protein Alignment Ir25a and Grin3b

DIOPT Version :9

• Sequence 1: NP_001260049.1
• Gene: Ir25a / 33683
• FlyBaseID: FBgn0031634
• Length: 947
• Species: Drosophila melanogaster
• Sequence 2: XP_006513350.1
• Gene: Grin3b / 170483
• MGIID: 2150393
• Length: 1138
• Species: Mus musculus
• Alignment Length: 963
• Identity: 194/963 - (20%)
• Similarity: 348/963 - (36%)
• Gaps: 281/963 - (29%)

  Fly    65 RYGLSVQLDSI--EANKSDAKVLLEAICNKYATSIEKKQTPH-LILDTTKSGIASETVKSFTQAL 126
            |.|.||:|.::  .|..:.|:||.       |.:....:.|| |.|:..  .:||.|....:.|.
Mouse   114 RAGASVRLAALLPRAPAARARVLA-------ALATPSPRLPHNLSLELV--AVASPTRDPASLAR 169

  Fly   127 GLPTISASYGQQGDLRQWRDLDEAKQKY-LLQVM------PPADIIPEAIRSIV-----IHMNIT 179
            ||..:.|..|....:    ...||:.:. |||.:      |...::...:|:.:     .|:.:.
Mouse   170 GLCQVLAPPGVVASI----TFPEARPELRLLQFLAAATETPVLSVLRREVRAPLGAPTPFHLQLD 230

  Fly   180 NAAILYD-----DSFVMDHKYKSL---LQNIQTRHVITAIAKDGKREREEQIEKLRNLDINN--- 233
            .|:.|..     .|.|..|.::.:   |..::....:..:......:..:.:..|..||..|
Mouse   231 WASPLETILDVLVSLVRAHAWEDIALVLCRVRDPSGLVTLWTSRASQAPKFVLDLSQLDSGNDSL 295

  Fly   234 ---FFILGTLQS-----------------IRMVLESVKPAYFERNFAWHAITQNEGEISSQRDNA 278
               ..:||||:.                 ...|||:..|..     .|
Mouse   296 RATLALLGTLEGGGTPVSAAVLLGCSTAHAHEVLEAAPPGP-----QW----------------- 338

  Fly   279 TIMFMKPMAYTQYRDRLGLLRTTYNLNE--EPQLSSAFY--FDLALRSFLTIKEM-----LQSGA 334
              :...|:. .:...:.||......|.|  :|.|.:|.:  .:|..|:..::..|     |...|
Mouse   339 --LLGTPLP-AEALPKTGLPPGVLVLGETGQPSLEAAVHDMVELVARALSSMALMHPERALLPAA 400

  Fly   335 WPKDMEYLNCDDFQGGNTPQRNLDLRDYFTKITEPTSYGTFDLVTQSTQPFNGHSFMKFEMDINV 399
                   :||:|.:.|.:......|..:.                 |...|.|.:        ..
Mouse   401 -------VNCEDLKTGGSESTARTLARFL-----------------SNTSFQGRT--------GA 433

  Fly   400 LQIRGGSSVNSK-------------------SIGKWISGL------NSELIVKDEEQMKNLTADT 439
            :.:.|.|.|:..                   ::|.|..|.      .:.|.|...   ....|..
Mouse   434 VWVAGSSQVHVSRHFKVWSLRRDPLGAPAWATVGSWQDGQLDFQPGAAALRVPSP---SGTQARP 495

  Fly   440 VYRIFTVVQAPFIM-----RDETAPKGY---------------------------------KGYC 466
            ..|:.|:|:.||:.     .|...|.|.                                 .|||
Mouse   496 KLRVVTLVEHPFVFTRESDEDGQCPAGQLCLDPGTNDSARLDALFTALENGSVPRTLRRCCYGYC 560

  Fly   467 IDLINEIAAIVHFDYTIQEVEDGKFGNMDENGQWNGIVKKLMDKQADIGLGSMSVMAEREIVIDF 531
            |||:..:|..:.||:.:..|.|||:|.: .:|:|.|:|..|:..:|.:.:.|.|:.:.|..|:||
Mouse   561 IDLLERLAEDLAFDFELYIVGDGKYGAL-RDGRWTGLVGDLLAGRAHMAVTSFSINSARSQVVDF 624

  Fly   532 TVPYYDLVGITIMMQRPSSPSSLFKFLTVLETNVWLCILAAYFFTSFLMWIFDRWSPYSYQ---N 593
            |.|::. ..:.||::...:.|.:..|:..|..::|:.:.||...|:..:.:::..|||...   .
Mouse   625 TSPFFS-TSLGIMVRTRDTASPIGAFMWPLHWSMWVGVFAALHLTALFLTLYEWRSPYGLTPRGR 688

  Fly   594 NREKYKDDEEKREFNLKECLWFCMTSLTPQG-GGEAPKNLSGRLVAATWWLFGFIIIASYTANLA 657
            ||...        |:....|..|...|..:. ..:.||..:||.:...|.:|..::::|||||||
Mouse   689 NRGTV--------FSYSSALNLCYAILFGRTVSSKTPKCPTGRFLMNLWAIFCLLVLSSYTANLA 745

  Fly   658 AFLTVSRLDTPVESLDDLAKQYKILYAPLNGSSAMTYFERMSNIEQMFYEIWKDLSLNDSLTAVE 722
            |.:...:.                             ||.:|.|.        |..|:
Mouse   746 AVMVGDKT-----------------------------FEELSGIH--------DPKLH------- 766

  Fly   723 RSKLAVWDYPVSD-KYTKMWQAMQEAKLPATLDEAVARVRNSTAAT---GF-----------AFL 772
                    :|... ::..:|::..||.:.|:..|..|.:|..:|.|   |.           ||:
Mouse   767 --------HPSQGFRFGTVWESSAEAYIKASFPEMHAHMRRHSAPTTPHGVAMLTSDPPKLNAFI 823

  Fly   773 GDATDIRY-LQL-TNCDLQVVGEEFSRKPYAIAVQQGSHLKDQFNNAILTLLNKRQLEKLKEKWW 835
            .|.:.:.| :.: .:|.|..||:.|:.:.|.|.:.|.|.|....:..|....:...::.|.:||:
Mouse   824 MDKSLLDYEVSIDADCKLLTVGKPFAIEGYGIGLPQNSPLTSNLSEFISRYKSSGFIDLLHDKWY 888

  Fly   836 KNDEALAKCDK---PEDQSDGISIQNIGGVFIVIFVGIGMACITLVFEYWWYR 885
            |    :..|.|   ...::..:.:.::.|:|:::.:|:|.|.:|.:.|:.:||
Mouse   889 K----MVPCGKRVFAVTETLQMGVYHLSGLFVLLCLGLGSALLTSLGEHVFYR 937

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	40..426	CDD:107378	77/440 (18%)
		PBP2_iGluR_putative	438..836	CDD:270435	103/456 (23%)
		Lig_chan	565..870	CDD:278489	67/328 (20%)
Grin3b	XP_006513350.1	PBP1_iGluR_NMDA_NR3	141..481	CDD:380600	66/402 (16%)
		PBP2_iGluR_NMDA_Nr3	494..888	CDD:270438	102/455 (22%)
		Lig_chan	656..922	CDD:365843	67/329 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846672
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830