Protein Alignment Ir25a and gria3a

DIOPT Version :10

• Sequence 1: NP_001260049.1
• Gene: Ir25a / 33683
• FlyBaseID: FBgn0031634
• Length: 947
• Species: Drosophila melanogaster
• Sequence 2: XP_073805840.1
• Gene: gria3a / 170452
• ZFINID: ZDB-GENE-020125-5
• Length: 940
• Species: Danio rerio
• Alignment Length: 1020
• Identity: 267/1020 - (26%)
• Similarity: 432/1020 - (42%)
• Gaps: 254/1020 - (24%)

  Fly     2 ILMNPKTSKILWLLGFLSLLSSFSLEIAAQTTQNINVLFINEVDNEPAAKAVEVVLTYLKKNIR- 65
            :|:.|      ||:  |...:.|..:|      ||..||:.....|.:|....|.|....:||.
Zfish     9 VLLLP------WLV--LQTQAGFPNQI------NIGGLFMRSTVQEHSAFRFAVQLYNTNQNITE 59

  Fly    66 --YGLSVQLDSIEANKSDAKVLLEAICNKYATSI-------EKKQTPHLILDTTKSGIASETVKS 121
              :.|:..:|::|::.|.:  :..|.|::::..:       :::              :..|:.|
Zfish    60 KPFHLNYNVDNLESSNSFS--VTHAFCSQFSRGVYAIFGFYDRR--------------SMNTLTS 108

  Fly   122 FTQALGLPTISASYGQQGDLRQWRDLDEAKQKYLLQVMPPADIIPEAIRSIVIHMNITNAAILYD 186
            |..||....|:.|:....|:           :::||:.|.   :..|:.|::.|........|||
Zfish   109 FCGALHTSFITPSFPTDTDV-----------QFVLQMRPS---LRGALLSLLAHYKWEKFVYLYD 159

  Fly   187 DSFVMDHKYKSLLQNIQTRHV-----ITAIAKDG---KREREEQIEKLRNLDINNFFILGTLQSI 243
                .|..: |:||.|....|     :||.:...   ..|....||::.......|.|...::.|
Zfish   160 ----TDRGF-SILQAIMESAVMNNWQVTARSVGNIVDPLEYRRIIEEMDRRQEKRFLIDCEVERI 219

  Fly   244 RMVLESVKPAYFERNFAWHAITQNEG-------EISSQRDNAT-IMFMKP-----MAYTQYRDRL 295
            ..:||.|..| .:.:..:|.|..|.|       ::.|...|.| ...:.|     ..:.|..:||
Zfish   220 NSILEQVVIA-GKNSRGYHYILANLGFTNMSLDKVFSGGANITGFQIINPDSPIVQQFLQRWERL 283

  Fly   296 ----------GLLRTTYNLNEEPQLSSAFYFDLALRSFLTIKEMLQSG--------AWPKDMEY- 341
                      ..|:.|..|..:..|..|..|....|..:.|.....:|        .|.:.::.
Zfish   284 DEREFPESRSSPLKYTSALTHDAILVIAEAFRYLRRQRVDISRRGSAGDCLANPAVPWSQGIDIE 348

  Fly   342 --LNCDDFQG--GNTPQRNLDLRDYFTKITEPTSYGTFDLVTQSTQPFNGHSFMKFEMDINVLQI 402
              |.....||  ||....:...|..:|                                ::|.::
Zfish   349 RALKMVQVQGMTGNIQFDSFGRRSNYT--------------------------------VDVYEM 381

  Fly   403 RGGSSVNSKSIGKWISGLNSELIVKDEEQMKNLTADTVYR---IFTVVQAPFIM--RDETAPKG- 461
            :.|   .::.||.|........||  |:|:.|.::....|   :.|:::||::|  |:....:|
Zfish   382 KPG---GARKIGYWNEFEKFVYIV--EQQVTNESSSVENRTIVVTTIMEAPYVMYKRNYMQLEGN 441

  Fly   462 --YKGYCIDLINEIAAIVHFDYTIQEVEDGKFGNMD-ENGQWNGIVKKLMDKQADIGLGSMSVMA 523
              |:|||:||.:|||..|...|.:..|.|||:|..| |...|||:|.:|:..:|||.:..:::..
Zfish   442 DRYEGYCVDLASEIAKHVGIKYKLSIVADGKYGARDPETKTWNGMVGELVYGRADIAVAPLTITL 506

  Fly   524 EREIVIDFTVPYYDLVGITIMMQRP-SSPSSLFKFLTVLETNVWLCILAAYFFTSFLMWIFDRWS 587
            .||.||||:.|:..| ||:||:::| .|...:|.||..|...:|:||:.||...|.::::..|:|
Zfish   507 VREEVIDFSKPFMSL-GISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFS 570

  Fly   588 PYSYQ-NNREKYKD----DEEKREFNLKECLWFCMTSLTPQGGGEAPKNLSGRLVAATWWLFGFI 647
            ||.:. ::.|:.||    .:...:|.:...|||.:.:...||...:|::||||:|...||.|..|
Zfish   571 PYEWHLDDNEETKDPQTPPDPPNDFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLI 635

  Fly   648 IIASYTANLAAFLTVSRLDTPVESLDDLAKQYKILYAPLNGSSAMTYFERMSNIEQMFYEIWKDL 712
            ||:||||||||||||.|:.:|:||.:|||||.:|.|..|:..|...:|
Zfish   636 IISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFF----------------- 683

  Fly   713 SLNDSLTAVERSKLAVWDYPVSDKYTKMWQAMQEAKLPA----TLDEAVARVRNSTAATGFAFLG 773
                     .|||:||        |.|||..|:.|: |:    |..:.|||||.|...  ||||.
Zfish   684 ---------RRSKIAV--------YEKMWSYMKSAE-PSVFVKTTPDGVARVRKSKGK--FAFLL 728

  Fly   774 DATDIRYL-QLTNCDLQVVGEEFSRKPYAIAVQQGSHLKDQFNNAILTLLNKRQLEKLKEKWW-- 835
            ::|...|: |...||...||.....|.|.:|..:||.|:...|.|:|.|..:..|:|||.|||
Zfish   729 ESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALRSAVNLAVLKLNEQGLLDKLKNKWWYD 793

  Fly   836 --------KNDEALAKC------------------------------------DKPE-------- 848
                    .:.:..|:|                                    ||.|
Zfish   794 KGECGSGGGDSKHKARCPTVSLWLTDIRTPVNLAVLKLSEQGILDKLKNKWWYDKGECGTKDSGS 858

  Fly   849 -DQSDGISIQNIGGVFIVIFVGIGMACITLVFEYWWYRYRKNPRI 892
             |::..:|:.|:.|||.::..|:|:|....:.|:.:..:::..|:
Zfish   859 KDKTSALSLSNVAGVFYILVGGLGLAMTVALVEFCYKSHQETKRL 903

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	37..418	CDD:380606	82/434 (19%)
		PBP2_iGluR_putative	438..836	CDD:270435	155/427 (36%)
gria3a	XP_073805840.1	None