DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir25a and gria2b

DIOPT Version :9

Sequence 1:	NP_001260049.1	Gene:	Ir25a / 33683	FlyBaseID:	FBgn0031634	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	XP_005157361.1	Gene:	gria2b / 170451	ZFINID:	ZDB-GENE-020125-4	Length:	897	Species:	Danio rerio

Alignment Length:	1044	Identity:	264/1044 - (25%)
Similarity:	445/1044 - (42%)	Gaps:	274/1044 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LMNPKTSKILWLLGFLSLLSSFSLEIAAQTTQNINVLFINEVDNEPAAKAVEVVLTYLKKNIRYG 67
            |.|.....|..||| ::...|.|::|..        ||....|.|.:|..:.:|        ::|
Zfish     4 LKNLSICLIALLLG-MTTGGSPSVQIGG--------LFPRGADQEYSAFRIGMV--------QFG 51

  Fly    68 -----LSVQLDSIEANKSDAKVLLEAICNKYATSI-------EKKQTPHLILDTTKSGIASETVK 120
                 |:..:|::|...|.|  :....|::::..:       :||..              .|:.
Zfish    52 TAEFRLTPHIDNLEVANSFA--VTNCFCSQFSRGVYAIFGFYDKKSV--------------NTIT 100

  Fly   121 SFTQALGLPTISASYGQQGDLRQWRDLDEAKQKYLLQVMPPADIIPEAIRSIVIHMNITNAAILY 185
            ||...|.:..|:.|:...|:           |::::|:.|.   |...:.|::.:......|.||
Zfish   101 SFCGTLHVSFITPSFPLDGN-----------QQFIIQMRPD---IKGPLLSLIEYYKWDKFAYLY 151

  Fly   186 DDSFVM------------------------------DHKYKSLLQNIQT---RHVITAIAKDGKR 217
            |....:                              |..|:||.|:::.   |.||....:|..:
Zfish   152 DSDRGLTTLQVVLDTAAEKKWQVTAINVGNMKDERKDEAYRSLFQDLENKKERRVILDCEQDKVK 216

  Fly   218 EREEQ-------IEKLRNLDINNFFILGTLQSIR---------MVLESVKPAYFERNFAWHAITQ 266
            :..||       ::....:..|..|:.|.|..|:         .:::...|...:.:..|.|:.:
Zfish   217 DIMEQVITIGRHVKGYHYIIANLGFVDGDLSKIQYGGANVSGFQIVDFDDPLVSKFDQRWEALEE 281

  Fly   267 NE--GEISSQRDNATIMFMKPMAYTQ-----YRDRLGLLRTTYNLNEEPQLSSAFYFDLALRSFL 324
            .|  |..|..|..:.:.:......|:     ::.|:.:.|...|
Zfish   282 KEYPGADSKIRYTSALTYDAVQVMTEAFRYLHKQRIDISRRANN--------------------- 325

  Fly   325 TIKEMLQSGAWP--------KDMEYLNCDDFQGGNTPQRNLDLRDYFTKITEPTSYGTFDLVTQS 381
              .:.|.:.|.|        :.::.:..|...|      |:....|..::
Zfish   326 --GDCLANPAVPWAQGVEIERALKQVRVDGLTG------NIQFDQYGKRV--------------- 367

  Fly   382 TQPFNGHSFMKFEMDINVLQIRGGSSVNSKSIGKW-----ISGLNSELIVKDEEQMKNLTADTVY 441
                        ...:||::::...:|   .||.|     :....|:|...|...::|.|.
Zfish   368 ------------NYTVNVMELKSNGAV---KIGYWNEVDKMVVTKSDLFPNDTMGLENKTV---- 413

  Fly   442 RIFTVVQAPFIMRDETAP-----KGYKGYCIDLINEIAAIVHFDYTIQEVEDGKFGNMD-ENGQW 500
            .:.|:::||::|..:.|.     :.|:|||:||..|||....|.|.::.|.|||:|..| |...|
Zfish   414 IVTTILEAPYVMLKKNADLFMDNERYEGYCVDLAAEIAKHCGFKYQLKIVGDGKYGARDAETKIW 478

  Fly   501 NGIVKKLMDKQADIGLGSMSVMAEREIVIDFTVPYYDLVGITIMMQRP-SSPSSLFKFLTVLETN 564
            ||:|.:|:..:|||.:..:::...||.||||:.|:..| ||:||:::| .|...:|.||..|...
Zfish   479 NGMVGELVYGKADIAVAPLTITLVREEVIDFSKPFMSL-GISIMIKKPQKSKPGVFSFLDPLAYE 542

  Fly   565 VWLCILAAYFFTSFLMWIFDRWSPYSYQNNREKYKD-----DEEKREFNLKECLWFCMTSLTPQG 624
            :|:||:.||...|.::::..|:|||.:  :.|:|:|     :|...||.:...|||.:.:...||
Zfish   543 IWMCIVFAYIGVSVVLFLVSRFSPYEW--HTEEYEDGQIQTNESTNEFGIFNSLWFSLGAFMRQG 605

  Fly   625 GGEAPKNLSGRLVAATWWLFGFIIIASYTANLAAFLTVSRLDTPVESLDDLAKQYKILYAPLNGS 689
            ...:|::||||:|...||.|..|||:||||||||||||.|:.:|:||.:|||||.:|.|..|:..
Zfish   606 CDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSG 670

  Fly   690 SAMTYFERMSNIEQMFYEIWKDLSLNDSLTAVERSKLAVWDYPVSDKYTKMWQAMQEAKLPA--- 751
            |...:|                          .|||:|::|        |||..|:.|: |:
Zfish   671 STKEFF--------------------------RRSKIALFD--------KMWTYMKGAE-PSVFV 700

  Fly   752 -TLDEAVARVRNSTAATGFAFLGDATDIRYL-QLTNCDLQVVGEEFSRKPYAIAVQQGSHLKDQF 814
             |..|.|.|||.|...  :|:|.::|...|: |...||...||.....|.|.||..:||.|::..
Zfish   701 KTTAEGVMRVRKSKGK--YAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRNAV 763

  Fly   815 NNAILTLLNKRQLEKLKEKWWKNDEALAKCDK----PEDQSDGISIQNIGGVFIVIFVGIGMACI 875
            |.|:|.|..:..|:|||.|||.:.   .:|..    .::::..:|:.|:.|||.::..|:|:|.:
Zfish   764 NLAVLKLNEQGLLDKLKNKWWYDK---GECGSGGGDSKEKTSALSLSNVAGVFYILVGGLGLAML 825

  Fly   876 TLVFEYWWYRYRKNPRIIDVAEANAERSNAADHPGKLVDGVILGHSGE-------KFEKSKAA-- 931
            ..:.|: .|:.|...:.:.|..::|.||.|     :|   .:.|.:||       :|.|:..|
Zfish   826 VALVEF-CYKSRAEAKRMKVTFSDAMRSKA-----RL---SVTGSTGENGRVMSPEFPKAVHAVP 881

  Fly   932 -LRP 934
             :||
Zfish   882 FVRP 885

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	40..426	CDD:107378	72/466 (15%)
		PBP2_iGluR_putative	438..836	CDD:270435	152/414 (37%)
		Lig_chan	565..870	CDD:278489	110/318 (35%)
gria2b	XP_005157361.1	PBP1_iGluR_AMPA_GluR2	27..395	CDD:107384	72/472 (15%)
		ANF_receptor	55..377	CDD:279440	60/407 (15%)
		PBP2_iGluR_AMPA	410..790	CDD:270433	155/426 (36%)
		Lig_chan	542..820	CDD:278489	110/319 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591883
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.840