Protein Alignment Ir25a and gria2b

DIOPT Version :10

• Sequence 1: NP_001260049.1
• Gene: Ir25a / 33683
• FlyBaseID: FBgn0031634
• Length: 947
• Species: Drosophila melanogaster
• Sequence 2: XP_068069253.1
• Gene: gria2b / 170451
• ZFINID: ZDB-GENE-020125-4
• Length: 944
• Species: Danio rerio
• Alignment Length: 1091
• Identity: 269/1091 - (24%)
• Similarity: 447/1091 - (40%)
• Gaps: 321/1091 - (29%)

  Fly     3 LMNPKTSKILWLLGFLSLLSSFSLEIAAQTTQNINVLFINEVDNEPAAKAVEVVLTYLKKNIRYG 67
            |.|.....|..||| ::...|.|::|..        ||....|.|.:|..:.:|        ::|
Zfish     4 LKNLSICLIALLLG-MTTGGSPSVQIGG--------LFPRGADQEYSAFRIGMV--------QFG 51

  Fly    68 -----LSVQLDSIEANKSDAKVLLEAICNKYATSI-------EKKQTPHLILDTTKSGIASETVK 120
                 |:..:|::|...|.|  :....|::::..:       :||..              .|:.
Zfish    52 TAEFRLTPHIDNLEVANSFA--VTNCFCSQFSRGVYAIFGFYDKKSV--------------NTIT 100

  Fly   121 SFTQALGLPTISASYGQQGDLRQWRDLDEAKQKYLLQVMPPADIIPEAIRSIVIHMNITNAAILY 185
            ||...|.:..|:.|:...|:           |::::|:.|.   |...:.|::.:......|.||
Zfish   101 SFCGTLHVSFITPSFPLDGN-----------QQFIIQMRPD---IKGPLLSLIEYYKWDKFAYLY 151

  Fly   186 DDSFVM------------------------------DHKYKSLLQNIQT---RHVITAIAKDGKR 217
            |....:                              |..|:||.|:::.   |.||....:|..:
Zfish   152 DSDRGLTTLQVVLDTAAEKKWQVTAINVGNMKDERKDEAYRSLFQDLENKKERRVILDCEQDKVK 216

  Fly   218 EREEQ-------IEKLRNLDINNFFILGTLQSIR---------MVLESVKPAYFERNFAWHAITQ 266
            :..||       ::....:..|..|:.|.|..|:         .:::...|...:.:..|.|:.:
Zfish   217 DIMEQVITIGRHVKGYHYIIANLGFVDGDLSKIQYGGANVSGFQIVDFDDPLVSKFDQRWEALEE 281

  Fly   267 NE--GEISSQRDNATIMFMKPMAYTQ-----YRDRLGLLRTTYNLNEEPQLSSAFYFDLALRSFL 324
            .|  |..|..|..:.:.:......|:     ::.|:.:.|...|
Zfish   282 KEYPGADSKIRYTSALTYDAVQVMTEAFRYLHKQRIDISRRANN--------------------- 325

  Fly   325 TIKEMLQSGAWP--------KDMEYLNCDDFQGGNTPQRNLDLRDYFTKITEPTSYGTFDLVTQS 381
              .:.|.:.|.|        :.::.:..|...|      |:....|..::
Zfish   326 --GDCLANPAVPWAQGVEIERALKQVRVDGLTG------NIQFDQYGKRV--------------- 367

  Fly   382 TQPFNGHSFMKFEMDINVLQIRGGSSVNSKSIGKW-----ISGLNSELIVKDEEQMKNLTADTVY 441
                        ...:||::::...:|   .||.|     :....|:|...|...::|.|.
Zfish   368 ------------NYTVNVMELKSNGAV---KIGYWNEVDKMVVTKSDLFPNDTMGLENKTV---- 413

  Fly   442 RIFTVVQAPFIMRDETAP-----KGYKGYCIDLINEIAAIVHFDYTIQEVEDGKFGNMD-ENGQW 500
            .:.|:::||::|..:.|.     :.|:|||:||..|||....|.|.::.|.|||:|..| |...|
Zfish   414 IVTTILEAPYVMLKKNADLFMDNERYEGYCVDLAAEIAKHCGFKYQLKIVGDGKYGARDAETKIW 478

  Fly   501 NGIVKKLMDKQADIGLGSMSVMAEREIVIDFTVPYYDLVGITIMMQRP-SSPSSLFKFLTVLETN 564
            ||:|.:|:..:|||.:..:::...||.||||:.|:..| ||:||:::| .|...:|.||..|...
Zfish   479 NGMVGELVYGKADIAVAPLTITLVREEVIDFSKPFMSL-GISIMIKKPQKSKPGVFSFLDPLAYE 542

  Fly   565 VWLCILAAYFFTSFLMWIFDRWSPYSYQNNREKYKD-----DEEKREFNLKECLWFCMTSLTPQG 624
            :|:||:.||...|.::::..|:|||.:  :.|:|:|     :|...||.:...|||.:.:...||
Zfish   543 IWMCIVFAYIGVSVVLFLVSRFSPYEW--HTEEYEDGQIQTNESTNEFGIFNSLWFSLGAFMRQG 605

  Fly   625 GGEAPKNLSGRLVAATWWLFGFIIIASYTANLAAFLTVSRLDTPVESLDDLAKQYKILYAPLNGS 689
            ...:|::||||:|...||.|..|||:||||||||||||.|:.:|:||.:|||||.:|.|..|:..
Zfish   606 CDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSG 670

  Fly   690 SAMTYFERMSNIEQMFYEIWKDLSLNDSLTAVERSKLAVWDYPVSDKYTKMWQAMQEAKLPA--- 751
            |...:|                          .|||:|::|        |||..|:.|: |:
Zfish   671 STKEFF--------------------------RRSKIALFD--------KMWTYMKGAE-PSVFV 700

  Fly   752 -TLDEAVARVRNSTAATGFAFLGDATDIRYL-QLTNCDLQVVGEEFSRKPYAIAVQQGSHLKDQF 814
             |..|.|.|||.|...  :|:|.::|...|: |...||...||.....|.|.||..:||.|::..
Zfish   701 KTTAEGVMRVRKSKGK--YAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRNAV 763

  Fly   815 NNAILTLLNKRQLEKLKEKWWKNDEALAKCD--------KPEDQSDG------------------ 853
            |.|:|.|..:..|:|||.|||.:.   .:|.        .|.:||||
Zfish   764 NLAVLKLNEQGLLDKLKNKWWYDK---GECGSGGGDSKVSPREQSDGTPVNLAVLKLSEQGTLDK 825

  Fly   854 -------------------------ISIQNIGGVFIVIFVGIGMACITLVFEYWWYRYRKNPRII 893
                                     :|:.|:.|||.::..|:|:|.:..:.|: .|:.|...:.:
Zfish   826 LKNKWWYDKGECGAKDSGSKEKTSALSLSNVAGVFYILVGGLGLAMLVALVEF-CYKSRAEAKRM 889

  Fly   894 DVAEANAERSNAADHPGKLVDGVILGHSGE-------KFEKSKAA---LRP 934
            .|..::|.||.|     :|   .:.|.:||       :|.|:..|   :||
Zfish   890 KVTFSDAMRSKA-----RL---SVTGSTGENGRVMSPEFPKAVHAVPFVRP 932

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	37..418	CDD:380606	71/461 (15%)
		PBP2_iGluR_putative	438..836	CDD:270435	152/414 (37%)
gria2b	XP_068069253.1	PBP1_iGluR_AMPA_GluR2	27..397	CDD:380612	72/474 (15%)
		PBP2_iGluR_AMPA	410..790	CDD:270433	155/426 (36%)