DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir25a and gria2a

DIOPT Version :9

Sequence 1:	NP_001260049.1	Gene:	Ir25a / 33683	FlyBaseID:	FBgn0031634	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	XP_005170953.1	Gene:	gria2a / 170450	ZFINID:	ZDB-GENE-020125-3	Length:	893	Species:	Danio rerio

Alignment Length:	1026	Identity:	266/1026 - (25%)
Similarity:	447/1026 - (43%)	Gaps:	251/1026 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LLGFLSLLSSFSLEIAAQTTQNINVLFINEVDNEPAAKAVEVVLTYLKKNIRYG-----LSVQLD 73
            :|..|.|.:.:.|.:....:..|..||....|.|.:|..:.:|        ::|     |:..:|
Zfish     2 ILSGLLLPALWGLALGGSPSVQIGGLFPRGADQEYSAFRIGMV--------QFGTAEFRLTPHID 58

  Fly    74 SIEANKSDAKVLLEAICNKYATSI-------EKKQTPHLILDTTKSGIASETVKSFTQALGLPTI 131
            ::|...|.|  :....|::::..:       :||..              .|:.||.:.|.:..|
Zfish    59 NLEVANSFA--ITNCFCSQFSRGVYAIFGFYDKKSV--------------NTITSFCETLHVSFI 107

  Fly   132 SASYGQQGDLRQWRDLDEAKQKYLLQVMPPADIIPEAIRSIVIHMNITNAAILYDDSFVM----- 191
            :.|:...| |.|          ::||:.|.   |...:.|:|.:......|.|||....:
Zfish   108 TPSFPADG-LNQ----------FVLQMRPD---IKGPLISLVEYYKWEKFAYLYDSDRGLSTLQA 158

  Fly   192 -------------------------DHKYKSLLQNIQT---RHVITAIAKDGKREREEQIEKL-R 227
                                     |..|:||.|:::.   |.||....:|..::..||:..: |
Zfish   159 VLDTAAERKWQVTAINVGNLKDEWKDEAYRSLFQDLENKNERRVILDCEQDKVKDIMEQVITIGR 223

  Fly   228 NLD-----INNF-FILGTLQSIR---------MVLESVKPAYFERNFAWHAITQNEGEISSQRDN 277
            ::.     |.|| |:.|.|..|:         .:::...|...:.:..|.|:.:.|...:..|
Zfish   224 HVKGYHYIIANFGFVDGDLSKIQYGGANVSGFQIVDFDDPLVAKFDQRWEALEEKEYPGADSR-- 286

  Fly   278 ATIMFMKPMAYTQYRDRLGLLRTTYNLNEEPQLSSAFYFDLALRSFLTIKEMLQSGAWP------ 336
              |.:...:.|    |.:.::...:....:.::      |::.|.  ...:.|.:.|.|
Zfish   287 --IRYTSALTY----DAVQVMTEAFRFLHKQRI------DISRRG--NNGDCLANPAVPWAQGVE 337

  Fly   337 --KDMEYLNCDDFQGGNTPQRNLDLRDYFTKITEPTSYGTFDLVTQSTQPFNGHSFMKFEMDINV 399
              :.::.:..|...|      |:....|..::                           ...:||
Zfish   338 IERALKQVRVDGLTG------NIQFDQYGRRV---------------------------NYTVNV 369

  Fly   400 LQIRGGSSVNSKSIGKW-----ISGLNSELIVKDEEQMKNLTADTVYRIFTVVQAPFIMRDETAP 459
            ::::....|   .||.|     ::...|:|...|...|:|.|.    .:.|:::||::|..:.|.
Zfish   370 MELKNSGPV---KIGYWNEMDKMAVTKSDLFPNDTMGMENKTV----IVTTILEAPYVMLKKNAE 427

  Fly   460 -----KGYKGYCIDLINEIAAIVHFDYTIQEVEDGKFGNMD-ENGQWNGIVKKLMDKQADIGLGS 518
                 :.|:|||:||..|||....|.|.::.|.|||:|..| |...|||:|.:|:..:|||.:..
Zfish   428 LFTDNERYEGYCVDLAAEIAKHCGFKYQLRIVADGKYGARDAETKIWNGMVGELVYGKADIAVAP 492

  Fly   519 MSVMAEREIVIDFTVPYYDLVGITIMMQRP-SSPSSLFKFLTVLETNVWLCILAAYFFTSFLMWI 582
            :::...||.||||:.|:..| ||:||:::| .|...:|.||..|...:|:||:.||...|.::::
Zfish   493 LTITLVREEVIDFSKPFMSL-GISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFL 556

  Fly   583 FDRWSPYSYQNNREKYKD-----DEEKREFNLKECLWFCMTSLTPQGGGEAPKNLSGRLVAATWW 642
            ..|:|||.:  :.|:::|     .|...||.:...|||.:.:...||...:|::||||:|...||
Zfish   557 VSRFSPYEW--HTEEFEDGQLGPSESTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWW 619

  Fly   643 LFGFIIIASYTANLAAFLTVSRLDTPVESLDDLAKQYKILYAPLNGSSAMTYFERMSNIEQMFYE 707
            .|..|||:||||||||||||.|:.:|:||.:|||||.:|.|..|:..|...:|
Zfish   620 FFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDAGSTKEFF------------ 672

  Fly   708 IWKDLSLNDSLTAVERSKLAVWDYPVSDKYTKMWQAMQEAKLPATL----DEAVARVRNSTAATG 768
                          .|||:|::|        ||||.|:.|: |:..    .|.|.|||.|...
Zfish   673 --------------RRSKIALFD--------KMWQYMKSAE-PSVFVKNTVEGVLRVRKSKGK-- 712

  Fly   769 FAFLGDATDIRYL-QLTNCDLQVVGEEFSRKPYAIAVQQGSHLKDQFNNAILTLLNKRQLEKLKE 832
            :|:|.::|...|: |...||...||.....|.|.||..:||.|::..|.|:|.|..:..|:|||.
Zfish   713 YAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSALRNAVNLAVLKLNEQGLLDKLKN 777

  Fly   833 KWWKNDEALAKC----DKPEDQSDGISIQNIGGVFIVIFVGIGMACITLVFEYWWYRYRKNPRII 893
            |||.:.   .:|    .:.::::..:|:.|:.|||.::..|:|:|.:..:.|: .|:.|...:.:
Zfish   778 KWWYDK---GECGSGGGESKEKTSALSLSNVAGVFYILVGGLGLAMLVALVEF-CYKSRAEAKRM 838

  Fly   894 DVAEANAERSNAADHPGKLVDGVILGHSGEK-------FEKSKAA---LRP 934
            .:...:|.||.|     :|   .|.|.:||.       |.|:..|   |||
Zfish   839 KMTFTDAMRSKA-----RL---SITGSTGENGRVLTPDFSKAVHAVPYLRP 881

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	40..426	CDD:107378	77/459 (17%)
		PBP2_iGluR_putative	438..836	CDD:270435	151/414 (36%)
		Lig_chan	565..870	CDD:278489	109/318 (34%)
gria2a	XP_005170953.1	Periplasmic_Binding_Protein_Type_1	23..391	CDD:299141	77/457 (17%)
		ANF_receptor	51..373	CDD:279440	65/400 (16%)
		PBP2_iGluR_AMPA	406..783	CDD:270433	154/420 (37%)
		Lig_chan	538..816	CDD:278489	109/319 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591882
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.840