Protein Alignment Ir25a and Grin2c

DIOPT Version :10

• Sequence 1: NP_001260049.1
• Gene: Ir25a / 33683
• FlyBaseID: FBgn0031634
• Length: 947
• Species: Drosophila melanogaster
• Sequence 2: XP_017169765.1
• Gene: Grin2c / 14813
• MGIID: 95822
• Length: 1307
• Species: Mus musculus
• Alignment Length: 941
• Identity: 206/941 - (21%)
• Similarity: 353/941 - (37%)
• Gaps: 253/941 - (26%)

  Fly   103 PHLILDTTKSGIASETVKSFTQALGLPTISASYGQQGDLRQWRDLDEAKQKYL---LQVMP---- 160
            |.|:|.:.....|........||:   |::..:|..|.|:.........|.:|   |::.|
Mouse    69 PALLLTSLLGAWAGLGAGQGEQAV---TVAVVFGSSGPLQAQARTRLTPQNFLDLPLEIQPLTIG 130

  Fly   161 -----PADIIPE--------AIRSIVIHMNITNAAILYDDSFVMDHKYKSLLQNIQTRHVITAIA 212
                 |:.|:.:        .:..||...|:...|:.....||....:..:|.......|:....
Mouse   131 VNNTNPSSILTQICGLLGAARVHGIVFEDNVDTEAVAQLLDFVSSQTHVPILSISGGSAVVLTPK 195

  Fly   213 KDGKR--------EREEQI--EKLRNLDINNFFILGTLQ-SIRMVLESVKPAYFERNFAWHAITQ 266
            :.|..        |::.|:  :.|...|.:.|.::.:|. ...:.||.|:........:|..:..
Mouse   196 EPGSAFLQLGVSLEQQLQVLFKVLEEYDWSAFAVITSLHPGHALFLEGVRAVADASYLSWRLLDV 260

  Fly   267 NEGEIS-----------------------SQRDNATIMFMKPMAYTQYRDRLGLLRTTY-----N 303
            ...|:.                       ..|:.|.::|.:..       :.||:...:     |
Mouse   261 LTLELGPGGPRARTQRLLRQVDAPVLVAYCSREEAEVLFAEAA-------QAGLVGPGHVWLVPN 318

  Fly   304 L----NEEPQLSSAFYFDLALRSFLT----------IKE---MLQSGAWPKDMEY-------LNC 344
            |    .:.|..:    |.:.|.|.:|          :::   :|..||.....:|       .:|
Mouse   319 LALGSTDAPPAA----FPVGLISVVTESWRLSLRQKVRDGVAILALGAHSYRRQYGTLPAPAGDC 379

  Fly   345 DDFQGGNTPQRNLDLRDYFTKIT---EPTSYGTFDLVTQSTQ---PFNGHSFMKFEMDINVLQIR 403
            ....|..:|.|....| :...:|   ...|:.....:.|.|.   ..|.|..  :||
Mouse   380 RSHPGPVSPAREAFYR-HLLNVTWEGRDFSFSPGGYLVQPTMVVIALNRHRL--WEM-------- 433

  Fly   404 GGSSVNSKSIGKWISGL------------NSELIVKDEEQMKNLTADTV-YRIFTVVQAP----- 450
                     :|:|..|:            .|...|.|.   ::||..|: .|.|.:|::|
Mouse   434 ---------VGRWDHGVLYMKYPVWPRYSTSLQPVVDS---RHLTVATLEERPFVIVESPDPGTG 486

  Fly   451 ----------------FIMRDETAPKGY-----KGYCIDLINEIAAIVHFDYTIQEVEDGKFGNM 494
                            |...|.|.   |     ||:|||::.::|.:|.|.|.:..|.:||.|..
Mouse   487 GCVPNTVPCRRQSNHTFSSGDITP---YTKLCCKGFCIDILKKLAKVVKFSYDLYLVTNGKHGKR 548

  Fly   495 DENGQWNGIVKKLMDKQADIGLGSMSVMAEREIVIDFTVPYYDLVGITIMMQRPSSPSSLFKFLT 559
             ..|.|||::.::..|:||:.:||:::..||..:|||:||:.: .||::|:.|.:...|...||.
Mouse   549 -VRGVWNGMIGEVYYKRADMAIGSLTINEERSEIIDFSVPFVE-TGISVMVARSNGTVSPSAFLE 611

  Fly   560 VLETNVW-----LCILAAYFFTSFLMWIFDRWSPYSYQNNREKYKDDEEKREFNLKECLW----F 615
            .....||     :|:..    .:..:::|:.:||.||..|..|.|..... .|.:.:.:|    .
Mouse   612 PYSPAVWVMMFVMCLTV----VAITVFMFEYFSPVSYNQNLTKGKKSGGP-SFTIGKSVWLLWAL 671

  Fly   616 CMTSLTPQGGGEAPKNLSGRLVAATWWLFGFIIIASYTANLAAFLTVSRLDTPVESLDDLAKQY- 679
            ...:..|.   |.|:..:.:::...|..|..|.:||||||||||:...:....|..|.|  |::
Mouse   672 VFNNSVPI---ENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSD--KKFQ 731

  Fly   680 --KILYAPL------NGSSAMTYFER--MSNIEQMFYEIWK--DLSLNDSLTAVERSKLAVWDYP 732
              :..|.|.      |||:     ||  .||...|...:.|  ..|:.|:||:::
Mouse   732 RPQDQYPPFRFGTVPNGST-----ERNIRSNYRDMHTHMVKFNQRSVEDALTSLK---------- 781

  Fly   733 VSDKYTKMWQAMQEAKLPATLDEAVARVRNSTAATGFAFLGDATDIRYL--QLTNCDLQVV--GE 793
                       |....:...||               ||:.||..:.|:  :...|.|..:  |:
Mouse   782 -----------MGARHVSRKLD---------------AFIYDAAVLNYMAGKDEGCKLVTIGSGK 820

  Fly   794 EFSRKPYAIAVQQGSHLKDQFNNAILTLLNKRQLEKLKEKWWKNDEALAKCDKPEDQSDGISIQN 858
            .|:...|.||:|:.||.|...:.|:|..|...:.:||:..|.   ..:...:|.|..|..:.|.|
Mouse   821 VFATTGYGIAMQKDSHWKRAIDLALLQFLGDGETQKLETVWL---SGICHNEKNEVMSSKLDIDN 882

  Fly   859 IGGVFIVIFVGIGMACITLVFE---YWWYRY 886
            :.|||.::.|.:|:|.:...:|   ||..|:
Mouse   883 MAGVFYMLLVAMGLALLVFAWEHLVYWKLRH 913

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	37..418	CDD:380606	67/403 (17%)
		PBP2_iGluR_putative	438..836	CDD:270435	118/450 (26%)
Grin2c	XP_017169765.1	PBP1_iGluR_NMDA_NR2	90..446	CDD:380601	64/389 (16%)
		PBP2_iGluR_NMDA_Nr2	462..868	CDD:270436	120/467 (26%)
		NMDAR2_C	905..>980	CDD:463148	3/9 (33%)