Protein Alignment Ir25a and Grik2

DIOPT Version :9

• Sequence 1: NP_001260049.1
• Gene: Ir25a / 33683
• FlyBaseID: FBgn0031634
• Length: 947
• Species: Drosophila melanogaster
• Sequence 2: XP_011241422.1
• Gene: Grik2 / 14806
• MGIID: 95815
• Length: 943
• Species: Mus musculus
• Alignment Length: 943
• Identity: 239/943 - (25%)
• Similarity: 400/943 - (42%)
• Gaps: 238/943 - (25%)

  Fly    57 LTYLKKNIRYGLSVQLDSIEANKSDAKVLLEAICNKYATSIEKKQTPHLILDTTKSGIASETVKS 121
            |||..:.|..     .||.||:|.        .|::.:..:.      .|...:.|..|: .|:|
Mouse    76 LTYDTQKINL-----YDSFEASKK--------ACDQLSLGVA------AIFGPSHSSSAN-AVQS 120

  Fly   122 FTQALGLPTISASYGQQGDLRQWRDLDEAKQKYLLQVMPPADIIPEAIRSIVIHMNITNAAILYD 186
            ...|||:|.|...:..|        :.:.|..:.:.:.|....:..||..:|.........::||
Mouse   121 ICNALGVPHIQTRWKHQ--------VSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYD 177

  Fly   187 DSFVMDHKYKSLLQNIQTRHVITAIAKDGKREREEQIEKLRNLDINNFFILGTLQSIRMVLESVK 251
            ||..:          |:.:.:|.|.::...|      .|:|.|..:.       :..:.:|:.:|
Mouse   178 DSTGL----------IRLQELIKAPSRYNLR------LKIRQLPADT-------KDAKPLLKEMK 219

  Fly   252 PAYFERNFAWHAITQNEGEISSQRDNATIMFMKPMAYTQYRDRLGLLRTTYNLNEEPQLSSAFYF 316
                 |...:|.|      .....:.|..:..:.:|       :|::...|:           |.
Mouse   220 -----RGKEFHVI------FDCSHEMAAGILKQALA-------MGMMTEYYH-----------YI 255

  Fly   317 DLALRSF-LTIKEMLQSGAWPKDMEYLNCDDFQGGN------------TPQRNLDLRDYFTKITE 368
            ...|..| |.::....||........||.::.|..:            .|:.:..|.|.|.....
Mouse   256 FTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTTDA 320

  Fly   369 PTSYGTFDLVTQSTQPF----------NGHSFMKF------------------------------ 393
            ...|....:|:.:.|.|          |.|...:|
Mouse   321 ALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLTGRITFNKTNGLRT 385

  Fly   394 EMDINVLQIRGGSSVNSKSIGKW--ISGLNSELIVKDEEQMKNLTADTVYR---IFTVVQAPFIM 453
            :.|::|:.::   ....:.||.|  .||||  :....:.:..|:|.....|   :.|:::.|:::
Mouse   386 DFDLDVISLK---EEGLEKIGTWDPSSGLN--MTESQKGKPANITDSLSNRSLIVTTILEEPYVL 445

  Fly   454 RDETAPKGY-----KGYCIDLINEIAAIVHFDYTIQEVEDGKFGNMDE-NGQWNGIVKKLMDKQA 512
            ..::....|     :||||||:.|::.|:.|.|.|:.|||||:|..|: ||||||:|::|:|.:|
Mouse   446 FKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDVNGQWNGMVRELIDHKA 510

  Fly   513 DIGLGSMSVMAEREIVIDFTVPYYDLVGITIMMQRPSSPS-SLFKFLTVLETNVWLCILAAYFFT 576
            |:.:..:::...||.||||:.|:..| ||:|:.::|:..: .:|.||..|..::|:.||.||...
Mouse   511 DLAVAPLAITYVREKVIDFSKPFMTL-GISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGV 574

  Fly   577 SFLMWIFDR-----W------------------------------SPYSYQNNREKYKD-DEEKR 605
            |.::::..|     |                              |||.:.|......| |..:.
Mouse   575 SCVLFVIARQSKFSWFKYPNCSHYHHSQRCLCTQHLESYMELCLFSPYEWYNPHPCNPDSDVVEN 639

  Fly   606 EFNLKECLWFCMTSLTPQGGGEAPKNLSGRLVAATWWLFGFIIIASYTANLAAFLTVSRLDTPVE 670
            .|.|....||.:.:|..||....||.||.|:|...||.|..|||:||||||||||||.|:::|::
Mouse   640 NFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPID 704

  Fly   671 SLDDLAKQYKILYAPLNGSSAMTYFERMSNIEQMFYEIWKDLSLNDSLTAVERSKLAVWDYPVSD 735
            |.||||||.||.|..:...:.||:|                          ::||::.:|
Mouse   705 SADDLAKQTKIEYGAVEDGATMTFF--------------------------KKSKISTYD----- 738

  Fly   736 KYTKMWQAM---QEAKLPATLDEAVARVRNSTAATGFAFLGDATDIRYLQLTNCDLQVVGEEFSR 797
               |||..|   :::.|..:.:|.:.||..|    .:|||.::|.|.::...||:|..:|.....
Mouse   739 ---KMWAFMSSRRQSVLVKSNEEGIQRVLTS----DYAFLMESTTIEFVTQRNCNLTQIGGLIDS 796

  Fly   798 KPYAIAVQQGSHLKDQFNNAILTLLNKRQLEKLKEKWWKNDEALAKCDKPEDQS---DGISIQNI 859
            |.|.:....||..:|:...|||.|..:.:|..:|||||:.:..      ||::|   ..:.:|||
Mouse   797 KGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGC------PEEESKEASALGVQNI 855

  Fly   860 GGVFIVIFVGIGMACITLVFEYWWYRYRKNPRI 892
            ||:|||:..|:.::....|.|: .|:.:||.::
Mouse   856 GGIFIVLAAGLVLSVFVAVGEF-LYKSKKNAQL 887

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	40..426	CDD:107378	75/423 (18%)
		PBP2_iGluR_putative	438..836	CDD:270435	144/446 (32%)
		Lig_chan	565..870	CDD:278489	107/346 (31%)
Grik2	XP_011241422.1	PBP1_iGluR_Kainate	37..414	CDD:380605	75/422 (18%)
		Periplasmic_Binding_Protein_Type_2	430..835	CDD:389745	144/443 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846691
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.840