DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir25a and Grik1

DIOPT Version :9

Sequence 1:	NP_001260049.1	Gene:	Ir25a / 33683	FlyBaseID:	FBgn0031634	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	XP_006522977.1	Gene:	Grik1 / 14805	MGIID:	95814	Length:	949	Species:	Mus musculus

Alignment Length:	996	Identity:	263/996 - (26%)
Similarity:	422/996 - (42%)	Gaps:	245/996 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ILMNPKTSKILWLLGFLSLLSSFSLEIAAQTTQNINVL--FINEVDNEPA---AKAVEVVLTYLK 61
            :|:.|.    ||.......|..|...|..||:..:..:  ....|:|||.   ..|.:..:|.:.
Mouse     6 VLIQPG----LWTRDTSWTLLYFLCYILPQTSPQVLRIGGIFETVENEPVNVEELAFKFAVTSIN 66

  Fly    62 KN--------IRYGLS-VQL-DSIEANKSDAKVLLEAICNKYATSIEKKQTPHLILDTTKSGIAS 116
            :|        :.|.:. :.| ||.||::        ..|::.|..:.....|     :..|.:::
Mouse    67 RNRTLMPNTTLTYDIQRINLFDSFEASR--------RACDQLALGVAALFGP-----SHSSSVSA 118

  Fly   117 ETVKSFTQALGLPTISASYGQQGDLRQW-------RDLDEAKQKYLLQVMPPADIIPEAIRSIVI 174
              |:|...||.:|.|..         :|       |||      :.:.:.|....|..|:..:|:
Mouse   119 --VQSICNALEVPHIQT---------RWKHPSVDNRDL------FYINLYPDYAAISRAVLDLVL 166

  Fly   175 HMNITNAAILYDDSFVMDHKYKSLLQNIQTRHVITAIAKDGKREREEQIEKLRNLDINNFFILGT 239
            :.|.....::|:||..:          |:.:.:|.|.::...:      .|:|.|...|
Mouse   167 YYNWKTVTVVYEDSTGL----------IRLQELIKAPSRYNIK------IKIRQLPSGN------ 209

  Fly   240 LQSIRMVLESVKPAYFERNFAWHAITQNEGEISSQRDNATIMFMKPMA-YTQYRDRLGLLRTTYN 303
             :..:.:|:.:|... |....:....:...||..|     |:||..|. |..|      ..||.:
Mouse   210 -KDAKPLLKEMKKGK-EFYVIFDCSHETAAEILKQ-----ILFMGMMTEYYHY------FFTTLD 261

  Fly   304 LNEEPQLSSAFYFDLALRSFLTIKEMLQSGAWPKDMEYLNCDD--------------FQGGNTPQ 354
            |         |..||.|..:        ||........||.|:              .|....|:
Mouse   262 L---------FALDLELYRY--------SGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPE 309

  Fly   355 RNLDLRDYFTKITEP------------TSYGTFDLVTQSTQ-----PFN-GHSFMK--------- 392
            ..| |....|  ||.            .|:....|...|.|     |:. |..||.
Mouse   310 TGL-LDGVMT--TEAALMYDAVYMVAIASHRASQLTVSSLQCHRHKPWRLGPRFMNLIKEARWDG 371

  Fly   393 ----------------FEMDINVLQIRGGSSVNS----------KSIGKWISGLNSELIVKD--E 429
                            |::||..|:..|....:.          |.||.|.|  ||.|.:.|  .
Mouse   372 LTGRITFNKTDGLRKDFDLDIISLKEEGTEKASGEVSKHLYKVWKKIGIWNS--NSGLNMTDGNR 434

  Fly   430 EQMKNLT---ADTVYRIFTVVQAPFIM-RDETAP----KGYKGYCIDLINEIAAIVHFDYTIQEV 486
            ::..|:|   |:....:.|:::.|::| |....|    ..::|||:||:.|::.|:.|.|.::.|
Mouse   435 DRSNNITDSLANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFLYDVKLV 499

  Fly   487 EDGKFGNMDENGQWNGIVKKLMDKQADIGLGSMSVMAEREIVIDFTVPYYDLVGITIMMQRPSSP 551
            .|||:|..::.|:|||:||:|:|.:||:.:..:::...||.||||:.|:..| ||:|:.::|:..
Mouse   500 PDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTL-GISILYRKPNGT 563

  Fly   552 S-SLFKFLTVLETNVWLCILAAYFFTSFLMWIFDRWSPYSYQNNREKYKD-DEEKREFNLKECLW 614
            : .:|.||..|..::|:.:|.|....|.::::..|::||.:.|......| |..:..|.|....|
Mouse   564 NPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNSFW 628

  Fly   615 FCMTSLTPQGGGEAPKNLSGRLVAATWWLFGFIIIASYTANLAAFLTVSRLDTPVESLDDLAKQY 679
            |.:.:|..||....||.||.|:|...||.|..|||:||||||||||||.|:::|::|.||||||.
Mouse   629 FGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQT 693

  Fly   680 KILYAPLNGSSAMTYFERMSNIEQMFYEIWKDLSLNDSLTAVERSKLAVWDYPVSDKYTKMWQAM 744
            ||.|..:...|.||:|                          ::||::.        |.|||..|
Mouse   694 KIEYGAVRDGSTMTFF--------------------------KKSKIST--------YEKMWAFM 724

  Fly   745 ---QEAKLPATLDEAVARVRNSTAATGFAFLGDATDIRYLQLTNCDLQVVGEEFSRKPYAIAVQQ 806
               |::.|....||.:.||    ..|.:|.|.::|.|.|:...||:|..:|.....|.|.:....
Mouse   725 SSRQQSALVKNSDEGIQRV----LTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPI 785

  Fly   807 GSHLKDQFNNAILTLLNKRQLEKLKEKWWKNDEALAKCDKPEDQS---DGISIQNIGGVFIVIFV 868
            ||..:|:...|||.|..:.:|..:|||||:.:..      ||:.|   ..:.::||||:|||:..
Mouse   786 GSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGC------PEEDSKEASALGVENIGGIFIVLAA 844

  Fly   869 GIGMACITLVFEYWWYRYRKN 889
            |:.::....:.|: .|:.|||
Mouse   845 GLVLSVFVAIGEF-IYKSRKN 864

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	40..426	CDD:107378	94/473 (20%)
		PBP2_iGluR_putative	438..836	CDD:270435	139/407 (34%)
		Lig_chan	565..870	CDD:278489	105/311 (34%)
Grik1	XP_006522977.1	PBP1_iGluR_Kainate	38..431	CDD:380605	94/479 (20%)
Grik1	XP_006522977.1	Periplasmic_Binding_Protein_Type_2	446..815	CDD:389745	139/407 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846571
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.740