DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir25a and Grid1

DIOPT Version :9

Sequence 1:	NP_001260049.1	Gene:	Ir25a / 33683	FlyBaseID:	FBgn0031634	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	NP_032192.2	Gene:	Grid1 / 14803	MGIID:	95812	Length:	1009	Species:	Mus musculus

Alignment Length:	970	Identity:	237/970 - (24%)
Similarity:	414/970 - (42%)	Gaps:	179/970 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LWLLGFLSLLSSFSLEIAAQTTQNINVLFINEVDNEPAAK---AVEVVLTYLKKN--------IR 65
            ||||.::         ....|.:..:::.|..:..|.|||   ..::.::.|..|        |.
Mouse     6 LWLLPWI---------CQCVTVRADSIIHIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSEKIT 61

  Fly    66 YGLSVQLDSIEANKSDAKVLLEAICNKYATSIEKKQTPHLILDTTKSGIAS-ETVKSFTQALGLP 129
            |.:.|    ||||.....|  :..|:        ..|..::...|.:|.|| ..::|.|.|:.:|
Mouse    62 YSIKV----IEANNPFQAV--QEACD--------LMTQGILALVTSTGCASANALQSLTDAMHIP 112

  Fly   130 TISASYGQQGDLRQWRDLDEAK--QKYLLQVMPPADIIPEAIRSIVIHMNITNAAILYD------ 186
            .:.......|..|....|:.:.  :.|.|...||..:....:| :|..:......:.||
Mouse   113 HLFVQRNPGGSPRTACHLNPSPDGEAYTLASRPPVRLNDVMLR-LVTELRWQKFVMFYDSEYDIR 176

  Fly   187 --DSFV-------MDHKYKSLLQNIQTRHVITAIAKDGKREREEQIEKLRNLDINNFFILGTLQS 242
              .||:       :|...:.:.:||.  ||.|::....|   .|::.:.|:.......:|....:
Mouse   177 GLQSFLDQASRLGLDVSLQKVDKNIS--HVFTSLFTTMK---TEELNRYRDTLRRAILLLSPQGA 236

  Fly   243 IRMVLESVKPAYFERNFAWHAITQNEGE------ISSQRDNATIMFMKPMAYTQYRDRLGLLRTT 301
            ...:.|:|:.....::..|..:.:...:      :.|.....|::   ...:...:|....:|..
Mouse   237 HSFINEAVETNLASKDSHWVFVNEEISDPEILDLVHSALGRMTVV---RQIFPSAKDNQKCMRNN 298

  Fly   302 YNLNE---EP--------QLSSAFYFDLALRSFLTIKEMLQSGAWPKDMEYLNC-----DDFQGG 350
            :.::.   :|        |:|:.:.:|..|.........|:...| ..|..|||     ..:.||
Mouse   299 HRISSLLCDPQEGYLQMLQISNLYLYDSVLMLANAFHRKLEDRKW-HSMASLNCIRKSTKPWNGG 362

  Fly   351 NTPQRNLDL--RDYFTKITEPTSYGTFDLVTQSTQPFNGHSFMKFEMDINVLQIRGGSSVNSKSI 413
            .:   .||.  :.:.|.:|     |..:....|:.|     :::||       |.|  :..|::.
Mouse   363 RS---MLDTIKKGHITGLT-----GVMEFREDSSNP-----YVQFE-------ILG--TTYSETF 405

  Fly   414 GK-------WIS--GLNSELIVKDEEQMKNLTADTVYRIFTVVQAPFIMRDET---APKGYKGYC 466
            ||       |.|  |||..|   .|..|.:.......::.||::.||:|..|.   .||.|||:.
Mouse   406 GKDMRKLATWDSEKGLNGSL---QERPMGSRLQGLTLKVVTVLEEPFVMVAENILGQPKRYKGFS 467

  Fly   467 IDLINEIAAIVHFDYTIQEVEDGKFGNMDENGQWNGIVKKLMDKQADIGLGSMSVMAEREIVIDF 531
            ||:::.:|..:.|.|.|.:..||::|:...|..|||::.:|:.|:||:.:.::::..|||.|:||
Mouse   468 IDVLDALAKALGFKYEIYQAPDGRYGHQLHNTSWNGMIGELISKRADLAISAITITPERESVVDF 532

  Fly   532 TVPYYDLVGITIMMQRPSSPSSLFKFLTVLETNVWLCILAAYFFTSFLMWIFDRWSPYSYQNNRE 596
            :..|.| ..:.|::::|....|:|......:..||.||.||......|:::.:|......|:..:
Mouse   533 SKRYMD-YSVGILIKKPEEKISIFSLFAPFDFAVWACIAAAIPVVGVLIFVLNRIQAVRSQSATQ 596

  Fly   597 KYKDDEEKREFNLKECLWFCMTSLTPQGGGEAPKNLSGRLVAATWWLFGFIIIASYTANLAAFLT 661
                ........|...:|....:...|||..:..:::.|:|..:||||..|:.:|||||||||||
Mouse   597 ----PRPSASATLHSAIWIVYGAFVQQGGESSVNSVAMRIVMGSWWLFTLIVCSSYTANLAAFLT 657

  Fly   662 VSRLDTPVESLDDLAKQYKILYAPLNGSSAMTYFERMSN--IEQ--MFYEIWKDLSLNDSLTAVE 722
            |||:|.|:.:..||:||.::.|..:..|:...||.....  :||  .|.|:|:.:|.|...
Mouse   658 VSRMDNPIRTFQDLSKQLEMSYGTVRDSAVYEYFRAKGTNPLEQDSTFAELWRTISKNGGA---- 718

  Fly   723 RSKLAVWDYPVSDKYTKMWQAMQEAKLPATLDEAVARVRNSTAATGFAFLGDATDIRYLQLT--N 785
                   |..||:.                 .|.:.:.:..    .:|||.|...:.|..||  :
Mouse   719 -------DNCVSNP-----------------SEGIRKAKKG----NYAFLWDVAVVEYAALTDDD 755

  Fly   786 CDLQVVGEEFSRKPYAIAVQQGSHLKDQFNNAILTLLNKRQLEKLKEKWWKNDEALAKCD---KP 847
            |.:.|:|...|.|.|.||:|.||..:|.|:..||.|.:...|:.||:|||.:   ..:||   ..
Mouse   756 CSVTVIGNSISSKGYGIALQHGSPYRDLFSQRILELQDTGDLDVLKQKWWPH---TGRCDLTSHS 817

  Fly   848 EDQSDG--ISIQNIGGVFIVIFVGIGMACITLVFEYWWYR---YRKNPRIIDVAEANAER 902
            ..|::|  :.:.:..|||.::.:|:.:||:....|.||..   :::.|:  :..|.|.|:
Mouse   818 STQTEGKSLKLHSFAGVFCILAIGLLLACLVAALELWWNSNRCHQETPK--EDKEVNLEQ 875

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	40..426	CDD:107378	88/447 (20%)
		PBP2_iGluR_putative	438..836	CDD:270435	124/406 (31%)
		Lig_chan	565..870	CDD:278489	92/315 (29%)
Grid1	NP_032192.2	Interaction with CBLN1. /evidence=ECO:0000269\|PubMed:27418511	21..436		90/463 (19%)
		PBP1_iGluR_delta_1	25..423	CDD:107387	86/443 (19%)
		PBP2_iGluR_delta_1	436..806	CDD:270448	124/406 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..960
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846313
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.740