Protein Alignment Ir25a and Gria1

DIOPT Version :10

• Sequence 1: NP_001260049.1
• Gene: Ir25a / 33683
• FlyBaseID: FBgn0031634
• Length: 947
• Species: Drosophila melanogaster
• Sequence 2: NP_032191.2
• Gene: Gria1 / 14799
• MGIID: 95808
• Length: 907
• Species: Mus musculus
• Alignment Length: 989
• Identity: 254/989 - (25%)
• Similarity: 420/989 - (42%)
• Gaps: 275/989 - (27%)

  Fly    16 GFLSLLSSFSLEIAAQTTQNINV--LFINEVDNEPAAKAVEVVLTYLKKNIRYGLS--------- 69
            |||..:      :.|....||.:  ||.|:...|.||             .|:.||
Mouse    11 GFLGAV------VGANFPNNIQIGGLFPNQQSQEHAA-------------FRFALSQLTEPPKLL 56

  Fly    70 VQLDSIEANKSDAKVLLEAICNKYATSI------EKKQTPHLILDTTKSGIASETVKSFTQALGL 128
            .|:|.:  |.||:..:....|::::..:      .:::|.:::             .||..||.:
Mouse    57 PQIDIV--NISDSFEMTYRFCSQFSKGVYAIFGFYERRTVNML-------------TSFCGALHV 106

  Fly   129 PTISASYGQQGDLRQWRDLDEAKQKYLLQVMPPADIIPEAIRSIVIHMNITNAAILYDDSFVMDH 193
            ..|:.|:          .:|.:.| ::||:.|.   :.||:.||:.|........:||..
Mouse   107 CFITPSF----------PVDTSNQ-FVLQLRPE---LQEALISIIDHYKWQTFVYIYDAD----- 152

  Fly   194 KYKSLLQNI-----QTRHVITAI-----AKDGKR----EREEQIEKLRNLDINNFFILGTLQSIR 244
            :..|:||.:     :....:||:     .::|.|    :.|::.|:|..:|..:       :.:.
Mouse   153 RGLSVLQRVLDTAAEKNWQVTAVNILTTTEEGYRMLFQDLEKKKERLVVVDCES-------ERLN 210

  Fly   245 MVLESVKPAYFERN-FAWHAITQNEGEISSQRDNATIMFMKPMAYTQYRDRLGLLRTTYNLNEEP 308
            .:|..:  ...|:| ..:|.|..|.|
Mouse   211 AILGQI--VKLEKNGIGYHYILANLG--------------------------------------- 234

  Fly   309 QLSSAFYFDLALRSFLTIKEMLQSGAWPKDMEYLNCDDFQGGNTPQ--RNLDLRDYFTKI----T 367
                  :.|:.|..|   ||   |||.....:.:|..|.......|  |..|.||: |::    .
Mouse   235 ------FMDIDLNKF---KE---SGANVTGFQLVNYTDTIPARIMQQWRTSDARDH-TRVDWKRP 286

  Fly   368 EPTSYGTFDLVTQSTQPFNGHSFMKFEMDIN-------------------------VLQIR---- 403
            :.||..|:|.|....:.|  .|..:..:||:                         :.|:|
Mouse   287 KYTSALTYDGVKVMAEAF--QSLRRQRIDISRRGNAGDCLANPAVPWGQGIDIQRALQQVRFEGL 349

  Fly   404 -GGSSVNSK-------------------SIGKW------ISGLNSELIVKDEEQMKNLTADTVYR 442
             |....|.|                   .||.|      :..........|...::|.|    |.
Mouse   350 TGNVQFNEKGRRTNYTLHVIEMKHDGIRKIGYWNEDDKFVPAATDAQAGGDNSSVQNRT----YI 410

  Fly   443 IFTVVQAPFIMRDETAPK-----GYKGYCIDLINEIAAIVHFDYTIQEVEDGKFGNMD-ENGQWN 501
            :.|:::.|::|..:.|.:     .|:|||::|..|||..|.:.|.::.|.|||:|..| :...||
Mouse   411 VTTILEDPYVMLKKNANQFEGNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWN 475

  Fly   502 GIVKKLMDKQADIGLGSMSVMAEREIVIDFTVPYYDLVGITIMMQRP-SSPSSLFKFLTVLETNV 565
            |:|.:|:..:||:.:..:::...||.||||:.|:..| ||:||:::| .|...:|.||..|...:
Mouse   476 GMVGELVYGRADVAVAPLTITLVREEVIDFSKPFMSL-GISIMIKKPQKSKPGVFSFLDPLAYEI 539

  Fly   566 WLCILAAYFFTSFLMWIFDRWSPYSYQNNR-EKYKD---DEEKREFNLKECLWFCMTSLTPQGGG 626
            |:||:.||...|.::::..|:|||.:.:.. |:.:|   .::..||.:...|||.:.:...||..
Mouse   540 WMCIVFAYIGVSVVLFLVSRFSPYEWHSEEFEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQQGCD 604

  Fly   627 EAPKNLSGRLVAATWWLFGFIIIASYTANLAAFLTVSRLDTPVESLDDLAKQYKILYAPLNGSSA 691
            .:|::||||:|...||.|..|||:||||||||||||.|:.:|:||.:|||||.:|.|..|...|.
Mouse   605 ISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLEAGST 669

  Fly   692 MTYFERMSNIEQMFYEIWKDLSLNDSLTAVERSKLAVWDYPVSDKYTKMWQAMQEAKLPA----T 752
            ..:|                          .|||:||::        |||..|:.|: |:    |
Mouse   670 KEFF--------------------------RRSKIAVFE--------KMWTYMKSAE-PSVFVRT 699

  Fly   753 LDEAVARVRNSTAATGFAFLGDATDIRYL-QLTNCDLQVVGEEFSRKPYAIAVQQGSHLKDQFNN 816
            .:|.:.|||.|...  :|:|.::|...|: |...||...||.....|.|.||..:||.|::..|.
Mouse   700 TEEGMIRVRKSKGK--YAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSALRNPVNL 762

  Fly   817 AILTLLNKRQLEKLKEKWWKNDEALAKCDK----PEDQSDGISIQNIGGVFIVIFVGIGMACITL 877
            |:|.|..:..|:|||.|||.:.   .:|..    .:|::..:|:.|:.|||.::..|:|:|.:..
Mouse   763 AVLKLNEQGLLDKLKNKWWYDK---GECGSGGGDSKDKTSALSLSNVAGVFYILIGGLGLAMLVA 824

  Fly   878 VFEYWWYRYRKNPR 891
            :.|: .|:.|...:
Mouse   825 LIEF-CYKSRSESK 837

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	37..418	CDD:380606	85/473 (18%)
		PBP2_iGluR_putative	438..836	CDD:270435	146/413 (35%)
Gria1	NP_032191.2	PBP1_iGluR_AMPA_GluR1	26..392	CDD:380613	85/475 (18%)
		PBP2_iGluR_AMPA_GluR1	406..787	CDD:270447	149/425 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	857..881
		PDZ-binding	904..907