Protein Alignment Ir25a and Nmdar1

DIOPT Version :10

• Sequence 1: NP_001260049.1
• Gene: Ir25a / 33683
• FlyBaseID: FBgn0031634
• Length: 947
• Species: Drosophila melanogaster
• Sequence 2: XP_321646.4
• Gene: Nmdar1 / 1281696
• VectorBaseID: AGAMI1_011915
• Length: 966
• Species: Anopheles gambiae
• Alignment Length: 1036
• Identity: 234/1036 - (22%)
• Similarity: 417/1036 - (40%)
• Gaps: 203/1036 - (19%)

  Fly     4 MNPKTSKILWLLGFLSLLSSFSLEIAAQTTQNI-NVLFINEVDNEPAAKAVEVVLTYLKKNIRY- 66
            |.|.:..:|.|:...:||:.......:.:..|| .||..||.::..|     .|:.:|..:.:|
Mosquito     6 MLPASCMLLSLMIPQALLAQKPTGSESPSYYNIGGVLSNNESESHFA-----TVIAHLNFDQQYV 65

  Fly    67 --GLSVQLDSIEANKSDAKVLLEAICNKYATSIEKKQTPHLILDTTKSGIASETVKSFTQAL-GL 128
              |.:....:|..:|:..|..|. :| |:..|   ::...:::....:|..|....|:|... .:
Mosquito    66 PRGTTYYDKTIRIDKNPIKTALN-VC-KHLIS---RRVYAVVVSHEPTGDLSPAAVSYTSGFYQI 125

  Fly   129 PTISASYGQQGDLRQWRDLDEAKQKYLLQVMPP----ADIIPEAIRSIVIHMNITNAAILYDDSF 189
            |.|..|      .|:....|:......|:.:||    ||:..|    |:.|...|...|::..
Mosquito   126 PVIGIS------SREAAFSDKNIHVSFLRTVPPYYHQADVWLE----ILSHFGYTKVIIIHSS-- 178

  Fly   190 VMDHKYKSLLQNIQTRHVITAIAKDGKREREEQIEKLRNLDINNFFILG--TLQS-IRMVLESVK 251
              |...:::|...||.........|.:...|..:|....||..:.:::.  |.|| :.::..|.:
Mosquito   179 --DTDGRAVLGRFQTTSQTNYDDIDVRATVESIVEFEPKLDSFSSYLMDMKTAQSRVYLLYASQE 241

  Fly   252 PAY-FERNFAWHAITQNEGEISSQRDNATIMFMKPMAYTQYRDRLGLLRTTYN--LNEEPQLSSA 313
            .|| ..|:.|.|.:|          :...|..:...|.:......|::....|  .||...:..|
Mosquito   242 DAYVIFRDAAIHNMT----------EYGHIWIVTEQALSANNTPTGIIGLKLNNAENETDHIKDA 296

  Fly   314 FYFDLALRSFLTIKEMLQSGAWPKDMEYLNCDD----FQGGNTPQRNLDLRDYFTKITEPTS--- 371
            .|...:....:|:.|.:...  |||     |||    ::.|......|..|:    |...|.
Mosquito   297 IYILASAIKEMTVNETITEA--PKD-----CDDSGVIWESGKRLFGYLKTRN----IRGETGQVA 350

  Fly   372 --------YGTFDLVTQSTQPFNGHSFMK---FEMDINVLQIRGGSSVNSKSIGKWISGLNSELI 425
                    |..:|::    .....|||:|   |..|....::|  ..:|..|| .|.....
Mosquito   351 FDDNGDRMYAEYDVI----NVHENHSFVKVGSFHYDSEKRKMR--LKINDSSI-TWPGNTG---- 404

  Fly   426 VKDEEQMKNLTADTVYRIFTVVQAPFIMR------------DETAPKGY------------KGYC 466
                ::.:.:...|..::.|:.:.||:..            ||.....:            ||||
Mosquito   405 ----KKPEGIMIPTHLKVLTIEEKPFVYARKLLDDEIDCADDEVVCPHFNITNGNEQEYCCKGYC 465

  Fly   467 IDLINEIAAIVHFDYTIQEVEDGKFGNMDENG-----------QWNGIVKKLMDKQADIGLGSMS 520
            |||:..:|..::|.|.:....||:||:.....           :|||::.:|:.::||:.:..::
Mosquito   466 IDLLKALAQRINFTYDLALSPDGQFGHYQLKNHTTGIGTTVKKEWNGLIGELVAERADLIVAPLT 530

  Fly   521 VMAEREIVIDFTVPY-YDLVGITIMMQRPSSPSSLFKFLTVLETNVWLCILAAYFFTSFLMWIFD 584
            :..||...|:|:.|: |.  ||||:.::||..|:|..||......:|:.::.:....:.::::.|
Mosquito   531 INPERAEFIEFSKPFKYQ--GITILEKKPSRSSTLVSFLQPFSNTLWILVMVSVHVVALVLYLLD 593

  Fly   585 RWSPYSYQNNREKYK----DDEEKREFNLKECLWFCMTSLTPQGGGE-APKNLSGRLVAATWWLF 644
            |:||:.      ::|    |..|:...||...:||....|...|.|| .|::.|.|::...|..|
Mosquito   594 RFSPFG------RFKLSTTDGTEEDALNLSSAIWFAWGVLLNSGIGEGTPRSFSARVLGMVWAGF 652

  Fly   645 GFIIIASYTANLAAFLTVSRLDTPVESLDDLA---KQYKILYAPLNGSSAMTYFERMSNIEQMFY 706
            ..||:|||||||||||.:.|..|.:..::|..   ....:..|.:.|||...||.|...:..|:
Mosquito   653 AMIIVASYTANLAAFLVLERPKTKLTGINDARLRNTMENLTCATVKGSSVDMYFRRQVELSNMY- 716

  Fly   707 EIWKDLSLNDSLTAVERSKLAVWDYPVSDKYTKMWQAMQEAKLPATLDEAVARVRNSTAATGFAF 771
               :.:..|:                    |....||:|:.|     |..:           .||
Mosquito   717 ---RTMEANN--------------------YDTAEQAIQDVK-----DGKL-----------MAF 742

  Fly   772 LGDATDIRYLQLTNCDLQVVGEEFSRKPYAIAVQQGSHLKDQFNNAILTLLNKRQLEKLKEKWWK 836
            :.|::.:.|....:|:|...||.|.|..|.:.:|:||...|....|||.......:|.|.::|..
Mosquito   743 IWDSSRLEYEASKDCELVTAGELFGRSGYGVGLQKGSPWTDAVTLAILDFHESGFMESLDKEWIF 807

  Fly   837 NDEALAKCDKPEDQSDGISIQNIGGVFIVIFVGI--GMACITLVFEYWWYRYRKNPRIIDVAEAN 899
            :.. :.:|::.|...:.:.::|:.||||::..||  |:..|.:...|..::.:|..: :::|...
Mosquito   808 HGN-VQQCEQFEKTPNTLGLKNMAGVFILVGAGIVGGIGLIIIEVVYKKHQIKKQKK-MEIARHA 870

  Fly   900 AERSNAADHPGKL--------------VDGVILGHSGEKFEKSKAALRPRFNQYPATFKPR 946
            |::........|.              ::.|......:..|||:..:.|...:.|....|:
Mosquito   871 ADKWRGTIEKRKTLRASLAMQRQYNVGLNSVSKSVQSQNAEKSRYPILPPLPRTPERAWPK 931

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	37..418	CDD:380606	88/412 (21%)
		PBP2_iGluR_putative	438..836	CDD:270435	115/441 (26%)
Nmdar1	XP_321646.4	None