Protein Alignment Ir25a and LOC1276693

DIOPT Version :10

• Sequence 1: NP_001260049.1
• Gene: Ir25a / 33683
• FlyBaseID: FBgn0031634
• Length: 947
• Species: Drosophila melanogaster
• Sequence 2: XP_061500826.1
• Gene: LOC1276693 / 1276693
• VectorBaseID: AGAMI1_001614
• Length: 972
• Species: Anopheles gambiae
• Alignment Length: 1055
• Identity: 249/1055 - (23%)
• Similarity: 434/1055 - (41%)
• Gaps: 247/1055 - (23%)

  Fly     3 LMNPKTSKILWLLGFLSLLSSFSLEIAAQT---TQNINVLFINEVDNEPAAKAVEVVLTYLKKNI 64
            :|.|..:.:|     |..||.....::|..   |:.|.:..|.|...:....|.:..:.....|:
Mosquito    35 IMLPLAAALL-----LVALSHMQTPVSANAQPPTEKIPLGAIFEQGTDEIQSAFKFAMLNHNLNV 94

  Fly    65 ---RYGLSVQLDSIEANKSDAKVLLEAICNKYATSIEKKQTPHLILDTTKSGIASETVKSFTQAL 126
               |:.|...:|.|  |.:||..|.:.|||:::..:       ..:....|..:.:|:.|::...
Mosquito    95 TARRFELQAYVDVI--NTADAFKLSKLICNQFSRGV-------FAMLGAVSPDSFDTLHSYSNTF 150

  Fly   127 GLPTISASYGQQGDLRQWRDLDEAKQKYLLQVMPPADIIPEAIRSIVIHMNITNAAILYD--DSF 189
            .:|.::..:.::........||     :.:.:.|.   ..:||...|.:........:||  |..
Mosquito   151 QMPFVTPWFPEKVLTPSSGFLD-----FAISMRPD---YYQAIIDTVRYYGWDRIIYMYDSHDGL 207

  Fly   190 V-MDHKYKSLLQNIQTRHV----------------------------------ITAIAKD----- 214
            : :...|:.|....:|.||                                  .|.:|||
Mosquito   208 LRLQQIYQGLRPGNETFHVETVKRIANVSDAIEFLRTIEELNRWSRKHIVLDCSTELAKDIVVSH 272

  Fly   215 ------GKR------------ER-EEQIEKLRNLDINNFFILGTLQSIRMVLESVKPAYFERNFA 260
                  |||            :| |.::.:...::|..|.|:.|  |.:.|.|.:.        .
Mosquito   273 VRDITLGKRTYHYLLSGLVMDDRWESEVIEYGAINITGFRIVDT--SKKYVKEFLD--------G 327

  Fly   261 WHAI----TQNEGE--ISSQRDNATIMFMKPMAYTQYRDRLGLLRTTYN--LNEEPQLSSAFYFD 317
            |..:    :|..|:  ||:|   |.:|:          |.:.:|...::  :.::|....|:
Mosquito   328 WKRLDPTTSQGAGKELISAQ---AALMY----------DAVFVLVEAFSKIMRKKPDQFRAY--- 376

  Fly   318 LALRSFLTIKEMLQSGAWPKD-MEYLNCDDFQGGNTPQRNLD-LRDYFTKITEPTSYGTFDLVTQ 380
                   |::...|....|.: ...|:|:..:|..||..:.| :..|..|:  ..|..|.|:...
Mosquito   377 -------TMRNRGQPFNLPANGTRTLDCNTSKGWVTPWEHGDKISRYLRKV--EISGLTGDIRFN 432

  Fly   381 STQPFNGHSFMKFEMDINVLQIRGGSSVNSKSIGKWI--SGLNSELIVK------DEEQMKNLTA 437
            .......::....||.:|...::         :.:|.  .|| :.::.|      |....:|.|
Mosquito   433 EDGKRQNYTLHVVEMTVNSAMVK---------VAEWSDEGGL-APVVAKYTRLKTDMHYERNKT- 486

  Fly   438 DTVYRIFTVVQAPFIMRDETAP-------KGYKGYCIDLINEIAAIVHFDYTIQEVEDGKFG--N 493
               |.:.|:::.|:||..:..|       :.::|||.||...:|..:..:|.::.|:||::|  |
Mosquito   487 ---YIVTTIIEEPYIMLRQPEPGETLETNERFEGYCKDLAELVAKKLGINYELRIVKDGQYGSEN 548

  Fly   494 MDENGQWNGIVKKLMDKQADIGLGSMSVMAEREIVIDFTVPYYDLVGITIMMQRP-SSPSSLFKF 557
            .|..|.|:|:|.:|:.|:||..:..|::.:|||.||||:.|:..| ||:||::|| ....|:|.|
Mosquito   549 PDVKGGWDGMVGELVRKEADFAIAPMTITSERERVIDFSKPFMSL-GISIMIKRPVKQKPSVFSF 612

  Fly   558 LTVLETNVWLCILAAYFFTSFLMWIFDRWSPY-----SYQNNREKYKDDEEKREFNLKECLWFCM 617
            |..|...:|:|:|.:|...|.:::|..|:||:     :|...:..........||::....||.:
Mosquito   613 LNPLSKEIWVCVLFSYVGVSIVLYIVSRFSPFEWRLVNYNGEQPDAVPQATVNEFSILNSFWFAL 677

  Fly   618 TSLTPQGGGEAPKNLSGRLVAATWWLFGFIIIASYTANLAAFLTVSRLDTPVESLDDLAKQYKIL 682
            .:...||...:|:::|||:|.:.||.|..|:|:||||||||||||.|:.||:.|.:|||.|.::.
Mosquito   678 GAFMQQGCDISPRSISGRIVGSVWWFFTLILISSYTANLAAFLTVERMVTPINSPEDLASQTEVQ 742

  Fly   683 YAPLNGSSAMTYFERMSNIEQMFYEIWKDLSLNDSLTAVERSKLAVWDYPVSDKYTKMWQAMQEA 747
            |..|...|...:|.:            ..:||                      |::||:.|...
Mosquito   743 YGTLIHGSTWDFFRK------------SQISL----------------------YSRMWEYMNSR 773

  Fly   748 K--LPATLDEAVARVRNSTAATGFAFLGDATDIRYLQLTN----CDLQVVGEEFSRKPYAIAVQQ 806
            |  ...:.||.:.|||.|...  :|.|.::....|   ||    ||...||.....|.:.||...
Mosquito   774 KHLFVKSYDEGIRRVRTSKGK--YALLIESPKNEY---TNEREPCDTMKVGRNLDAKGFGIATPL 833

  Fly   807 GSHLKDQFNNAILTLLNKRQLEKLKEKWWKNDEALAKCDKPEDQSDGISIQNIGGVFIVIFVGIG 871
            ||.|:|..|.|:|:|....:|.||..|||.:.......||.:...:.:|:.|:.|:|.::..|:.
Mosquito   834 GSPLRDPINLAVLSLKENGELTKLVNKWWFDRTECKHYDKQDASRNELSLSNVAGIFYILIGGLL 898

  Fly   872 MACITLVFEYWWYRYRKNPRIIDVAEANAERSNAADHPGKLVDGVILGHSGEKFEKSKAALRPRF 936
            :|....:.|:......::...|.:::.....||:                     |::..:.|..
Mosquito   899 VALAVALVEFCMKSSNRSSNRIPLSDTMTSNSNS---------------------KNRLTMPPTA 942

  Fly   937 NQY---------PAT 942
            .:|         |||
Mosquito   943 REYDNGRIGYYTPAT 957

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	37..418	CDD:380606	79/456 (17%)
		PBP2_iGluR_putative	438..836	CDD:270435	136/418 (33%)
LOC1276693	XP_061500826.1	None