Protein Alignment Ir25a and Ir93a

DIOPT Version :10

• Sequence 1: NP_001260049.1
• Gene: Ir25a / 33683
• FlyBaseID: FBgn0031634
• Length: 947
• Species: Drosophila melanogaster
• Sequence 2: XP_061512014.1
• Gene: Ir93a / 1272000
• VectorBaseID: AGAMI1_007780
• Length: 876
• Species: Anopheles gambiae
• Alignment Length: 881
• Identity: 182/881 - (20%)
• Similarity: 310/881 - (35%)
• Gaps: 261/881 - (29%)

  Fly   163 DIIPEAIRSIVIHMNI---------TNAAIL-----------YDD--SFVMDHKYKSLLQNIQTR 205
            ||..||:|..::.::|         ||.||:           :|:  ..::|.| .|...|..|.
Mosquito   107 DIYQEAVRERLVMLSITDPDCPRLPTNNAIMIPRSDGSGSNAFDEVSQIILDMK-SSRAINWHTA 170

  Fly   206 HVITAIAKDGKRER-----EEQIEKLRNLDINNFFILGTLQS------IRMVLESVKPAYFERNF 259
            .::.....|.:..|     .|..|.::.|.:..|.|.....|      ||..|..:..||..|||
Mosquito   171 TLLYDQVYDAEISRCILSLLEDREGIKPLTLTEFKINAPTHSWEKRKEIRRTLLGIPTAYTGRNF 235

  Fly   260 AWHAITQNEG-----EISSQRDNATIMFMKPMAYTQYRDRLGLLRTTYNLNEEPQLSSAFYFDLA 319
            .  ||.....     |||..     :..:.|.|...|     |:..|...|.
Mosquito   236 I--AIVNIATLTLLMEISKD-----LKLVNPFAQWLY-----LIPNTEKANS------------- 275

  Fly   320 LRSFLTIKEMLQSG-----AWPKDMEYLNCDDFQGGNTPQRNLDLRDYFTKITEPTSYGTFDLVT 379
              :|.|...::..|     .:....:..||       |......:..|........|    .|:.
Mosquito   276 --NFTTQSTLINEGDNVAFVYNSGSKAQNC-------TVSVLCYIESYLLHFIRSLS----KLIR 327

  Fly   380 QSTQPFNGHSFMKFEMDINVLQIRGGSSVNSKSIGKWISGLNSELIVKDE----EQMKNLTADT- 439
            :....|...|..::|:      || .|....|:  |::..:.:.:..|||    .|.|..:|:|
Mosquito   328 EEQVVFGQISDEEWEI------IR-PSKQERKT--KFLQMIKAAITSKDECNKCSQWKIQSAETW 383

  Fly   440 --VYRI--------------FTVV-------QAPFIMRDETAPK---GYKGYCI----------- 467
              |||.              :|::       |..|::.|...|.   |::|..:
Mosquito   384 GYVYRTDFLTDGADLQERRKYTMLDIGYWSPQDGFMLTDALFPHTQYGFRGVQLIFYSYHNPPWQ 448

  Fly   468 ------------------DLINEIAAIVHFDYTIQEVEDGKF-GNMDENGQWNGIVKKLMDKQAD 513
                              |::||::..::|.||:...:..:. |::.|..  ...|..|....:|
Mosquito   449 FVAYNDSGSPVISSGVVYDILNELSRKLNFTYTMVISQPAEINGSLVEGN--TSSVYDLKTISSD 511

  Fly   514 IGLGSMSVMAEREIV---------------IDFTVPYYDLVGITIMMQRPSSPSSLFKFLTVLET 563
            |.....|.:...:|:               :.||.| ..:...:.::.||...|.:..||:...:
Mosquito   512 IPQEIFSTLVNNKILLAAVGATVNEKQKKFVSFTDP-ISIQTYSFVISRPRELSRVLLFLSPFGS 575

  Fly   564 NVWLCILAAYFFTSFLMWIFDRWSPYSYQNNREKYKDDEEKREFNLKECLWFCMTSLTPQGGGEA 628
            :.|||:.||......::...::.|||...:|:   ..|....:.|  .|.|:...:|..|||...
Mosquito   576 DTWLCLAAAVALMGPILCAINKLSPYYEVHNK---PTDTGLGKVN--NCFWYIYGALLQQGGLYL 635

  Fly   629 PKNLSGRLVAATWWLFGFIIIASYTANLAAFLTVSRLDTPVESLDDLAKQYKILYAPLNGSSAMT 693
            |...|||::..||||...:|:.:|..||.||||..::|.||..:..|          |.....||
Mosquito   636 PYADSGRIIIGTWWLVVLVIVTTYCGNLVAFLTFPKIDIPVNRVMQL----------LRNDRGMT 690

  Fly   694 Y-FERMSNIEQMFYEIWKDLSLNDSLTAVERSKLAVWDYPVSDKYTKMWQAMQEAKLPATLDEAV 757
            : ..|.:.:|:|         |.||               ...||.::::..|  .:....||.|
Mosquito   691 WSIRRGTFLEEM---------LMDS---------------TEPKYMQLYKGSQ--IIGELTDELV 729

  Fly   758 ARVRNSTAATGFAFLGDATDIRY------LQLTNCDLQVVGEEFSRKPYAIAVQQGSHLKDQFNN 816
            .|:.    |.....:....::||      |:...||..:..:||..:..|:.:.:.|
Mosquito   730 ERIE----AGQHVHIDWRNNLRYLMKRQFLRTDRCDFALSTDEFLDEQIALVMPKDS-------- 782

  Fly   817 AILTLLNKRQLEKLK--------EKWWKNDEALAKCDKPEDQSDG----ISIQN-------IGGV 862
            ..|.|:|    |::|        ::|      :|:....:|:..|    :.:||       :.|.
Mosquito   783 PYLELVN----EEIKRMHQFGFIQRW------VAQYLPAKDKCSGTGRVMDVQNHTVNSSDMAGS 837

  Fly   863 FIVIFVGI--GMACITLVFEYWWYRYRKNPRIIDVA 896
            :.::.:|.  |:......|...|||..:..:...||
Mosquito   838 YWILLLGFVSGLFVFVCEFAVAWYRKSRAAQAATVA 873

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	37..418	CDD:380606	60/297 (20%)
		PBP2_iGluR_putative	438..836	CDD:270435	102/484 (21%)
Ir93a	XP_061512014.1	None