Protein Alignment Ir25a and GRIN3B

DIOPT Version :10

• Sequence 1: NP_001260049.1
• Gene: Ir25a / 33683
• FlyBaseID: FBgn0031634
• Length: 947
• Species: Drosophila melanogaster
• Sequence 2: NP_619635.1
• Gene: GRIN3B / 116444
• HGNCID: 16768
• Length: 1043
• Species: Homo sapiens
• Alignment Length: 555
• Identity: 122/555 - (21%)
• Similarity: 225/555 - (40%)
• Gaps: 148/555 - (26%)

  Fly   442 RIFTVVQAPFIMR---DE-------------------------------TAPKGYK----GYCID 468
            |:.|:::.||:..   ||                               :||:..:    |||||
Human   418 RVVTLLEHPFVFARDPDEDGQCPAGQLCLDPGTNDSATLDALFAALANGSAPRALRKCCYGYCID 482

  Fly   469 LINEIAAIVHFDYTIQEVEDGKFGNMDENGQWNGIVKKLMDKQADIGLGSMSVMAEREIVIDFTV 533
            |:..:|....||:.:..|.|||:|.: .:|:|.|:|..|:..:|.:.:.|.|:.:.|..|:|||.
Human   483 LLERLAEDTPFDFELYLVGDGKYGAL-RDGRWTGLVGDLLAGRAHMAVTSFSINSARSQVVDFTS 546

  Fly   534 PYYDLVGITIMMQRPSSPSSLFKFLTVLETNVWLCILAAYFFTSFLMWIFDRWSPYSYQ---NNR 595
            |::. ..:.||::...:.|.:..|:..|..:.||.:.||...|:..:.:::..|||...   .||
Human   547 PFFS-TSLGIMVRARDTASPIGAFMWPLHWSTWLGVFAALHLTALFLTVYEWRSPYGLTPRGRNR 610

  Fly   596 EKYKDDEEKREFNLKECLWFCMTSLTPQG-GGEAPKNLSGRLVAATWWLFGFIIIASYTANLAAF 659
            ...        |:....|..|...|..:. ..:.||..:|||:...|.:|..::::||||||||.
Human   611 STV--------FSYSSALNLCYAILFRRTVSSKTPKCPTGRLLMNLWAIFCLLVLSSYTANLAAV 667

  Fly   660 LTVSRLDTPVESLDDLAKQYKILYAPLNGSSAMTYFERMSNIEQMFYEIWKDLSLNDSLTAVERS 724
            :...:.                             ||.:|.|.        |..|:
Human   668 MVGDKT-----------------------------FEELSGIH--------DPKLH--------- 686

  Fly   725 KLAVWDYPVSD-KYTKMWQAMQEAKLPATLDEAVARVRNSTAAT---GF-----------AFLGD 774
                  :|... ::..:|::..||.:..:..:..|.:|..:|.|   |.           ||:.|
Human   687 ------HPAQGFRFGTVWESSAEAYIKKSFPDMHAHMRRHSAPTTPRGVAMLTSDPPKLNAFIMD 745

  Fly   775 ATDIRY-LQL-TNCDLQVVGEEFSRKPYAIAVQQGSHLKDQFNNAILTLLNKRQLEKLKEKWWKN 837
            .:.:.| :.: .:|.|..||:.|:.:.|.|.:.|.|.|....:..|....:...::.|.:||:|
Human   746 KSLLDYEVSIDADCKLLTVGKPFAIEGYGIGLPQNSPLTSNLSEFISRYKSSGFIDLLHDKWYK- 809

  Fly   838 DEALAKCDK---PEDQSDGISIQNIGGVFIVIFVGIGMACITLV------------------FEY 881
               :..|.|   ...::..:||.:..|:|:::.:|:|.|.::.:                  .:|
Human   810 ---MVPCGKRVFAVTETLQMSIYHFAGLFVLLCLGLGSALLSSLGEHAFFRLALPRIRKGSRLQY 871

  Fly   882 WWYRYRKNPRIIDV--AEANAERSNAADHPGKLVD 914
            |.:..:|..|.::.  .|.:.|.:..|:..|..|:
Human   872 WLHTSQKIHRALNTEPPEGSKEETAEAEPSGPEVE 906

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	37..418	CDD:380606
		PBP2_iGluR_putative	438..836	CDD:270435	103/452 (23%)
GRIN3B	NP_619635.1	PBP1_iGluR_NMDA_NR3	29..401	CDD:380600
		PBP2_iGluR_NMDA_Nr3	415..808	CDD:270438	102/451 (23%)
		Lig_chan	574..841	CDD:459656	69/330 (21%)