DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir25a and GRIN3A

DIOPT Version :9

Sequence 1:	NP_001260049.1	Gene:	Ir25a / 33683	FlyBaseID:	FBgn0031634	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	NP_597702.2	Gene:	GRIN3A / 116443	HGNCID:	16767	Length:	1115	Species:	Homo sapiens

Alignment Length:	984	Identity:	208/984 - (21%)
Similarity:	371/984 - (37%)	Gaps:	287/984 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 VDNEPAAKAVEVVLTYLKKNIRYGLSVQ-LDSIEANKSDAKVL----------------LEAICN 91
            |||          |..::..:.|.||:: :.:|||...|..:|                |:::|
Human   132 VDN----------LNRVEGLLPYNLSLEVVMAIEAGLGDLPLLPFSSPSSPWSSDPFSFLQSVC- 185

  Fly    92 KYATSIEKKQTPHLILDTTKSGIASETVKSFTQALG-------------LPTISASYGQ-----Q 138
                        |.::   ..|:::  :.:|.|:.|             :|.||....:     |
Human   186 ------------HTVV---VQGVSA--LLAFPQSQGEMMELDLVSLVLHIPVISIVRHEFPRESQ 233

  Fly   139 GDLRQWRDLDEAKQKYLLQVMPPADIIPEAIRSIVIHMNITNAAIL--YDDSFVMDHKYKSLLQN 201
            ..|.....|:.:       :...||:..    ||:...|..|.::|  .:|..:.|  :..|.||
Human   234 NPLHLQLSLENS-------LSSDADVTV----SILTMNNWYNFSLLLCQEDWNITD--FLLLTQN 285

  Fly   202 IQTRHV-----ITA---IAKDGKREREEQIEKLRNLDINNFFILGTLQSIRMVLE-----SVKPA 253
            ....|:     |||   ..:|.....:.|:|.::|...........::|||.:.|     .|.|.
Human   286 NSKFHLGSIINITANLPSTQDLLSFLQIQLESIKNSTPTVVMFGCDMESIRRIFEITTQFGVMPP 350

  Fly   254 YFERNFAW-HAITQNEGEISSQRDNATIMFMKPMAYTQYRDRLGLL---RTTYNLNEEPQLSSAF 314
                ...| ...:||..|:.::.        .|         |||:   :||.::.|. .:..|
Human   351 ----ELRWVLGDSQNVEELRTEG--------LP---------LGLIAHGKTTQSVFEH-YVQDA- 392

  Fly   315 YFDLALRSFLTIKEMLQS--GAWPKDMEYLNCDDFQGGNTPQRNLDLRDYFTKITEPTSYGTFDL 377
             .:|..|:..| ..|:|.  ...|..|   ||.:.:     ..||....|.::....|:
Human   393 -MELVARAVAT-ATMIQPELALIPSTM---NCMEVE-----TTNLTSGQYLSRFLANTT------ 441

  Fly   378 VTQSTQPFNGHSFMKFEMDINVLQIRGGSSVNSKS-------------------IGKWISGLNSE 423
                   |.|.|        ..::::|.:.|:|::                   :|.|..|
Human   442 -------FRGLS--------GSIRVKGSTIVSSENNFFIWNLQHDPMGKPMWTRLGSWQGG---- 487

  Fly   424 LIVKD-----EEQMKNLT-----ADTVYRIFTVVQAPFIM------------------------- 453
            .||.|     |:..::.|     :....|:.|:::.||:.
Human   488 KIVMDYGIWPEQAQRHKTHFQHPSKLHLRVVTLIEHPFVFTREVDDEGLCPAGQLCLDPMTNDSS 552

  Fly   454 -----------RDETAPKGYK----GYCIDLINEIAAIVHFDYTIQEVEDGKFGNMDENGQWNGI 503
                       .::|.|..:|    ||||||:.:||..::||:.:..|.|||:|.. :||.|.|:
Human   553 TLDSLFSSLHSSNDTVPIKFKKCCYGYCIDLLEKIAEDMNFDFDLYIVGDGKYGAW-KNGHWTGL 616

  Fly   504 VKKLMDKQADIGLGSMSVMAEREIVIDFTVPYYDL-VGITIMMQRPSSPSSLFKFLTVLETNVWL 567
            |..|:...|.:.:.|.|:...|..|||||.|::.. :||.:..:..::|  :..|:..|...:||
Human   617 VGDLLRGTAHMAVTSFSINTARSQVIDFTSPFFSTSLGILVRTRDTAAP--IGAFMWPLHWTMWL 679

  Fly   568 CILAAYFFTSFLMWIFDRWSPYSYQ---NNREKYKDDEEKREFNLKECLWFCMTSLTPQGGG-EA 628
            .|..|...|:..:.:::..||:...   .||.|.        |:....|..|...|..:... :.
Human   680 GIFVALHITAVFLTLYEWKSPFGLTPKGRNRSKV--------FSFSSALNICYALLFGRTVAIKP 736

  Fly   629 PKNLSGRLVAATWWLFGFIIIASYTANLAAFLTVSRLDTPVESLDDLAKQYKILYAPLNGSSAMT 693
            ||..:||.:...|.:|....:::|||||||.:...::...:..:.|     ..|:.|..|.
Human   737 PKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHD-----PKLHHPSQGF---- 792

  Fly   694 YFERMSNIEQMFYEIWKDLSLNDSLTAVERSKLAVWDYPVSDKYTKMWQAMQEAKLPATLDEAVA 758
               |...:.:...|                      || |...:.:|.:.|:...:|||.| .|.
Human   793 ---RFGTVRESSAE----------------------DY-VRQSFPEMHEYMRRYNVPATPD-GVE 830

  Fly   759 RVRNSTAATGFAFLGDATDIRY-LQL-TNCDLQVVGEEFSRKPYAIAVQQGSHLKDQFNNAILTL 821
            .::|...... ||:.|...:.| :.: .:|.|..||:.|:.:.|.|.:...|.|....:..|...
Human   831 YLKNDPEKLD-AFIMDKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPPNSPLTANISELISQY 894

  Fly   822 LNKRQLEKLKEKWWKNDEALAKCDKPE---DQSDGISIQNIGGVFIVIFVGIGMACITLVFEYWW 883
            .:...::.|.:||::    :..|.|..   .::..:.|::..|:|:::.:|.|::.:|.:.|:..
Human   895 KSHGFMDMLHDKWYR----VVPCGKRSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHIV 955

  Fly   884 YRYRKNPRI 892
            ||... |||
Human   956 YRLLL-PRI 963

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	40..426	CDD:107378	85/456 (19%)
		PBP2_iGluR_putative	438..836	CDD:270435	104/444 (23%)
		Lig_chan	565..870	CDD:278489	66/313 (21%)
GRIN3A	NP_597702.2	PBP1_iGluR_NMDA_NR3	30..497	CDD:107372	88/463 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	59..118
		ANF_receptor	127..469	CDD:279440	82/431 (19%)
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	103/443 (23%)
		Lig_chan	676..942	CDD:278489	66/314 (21%)
		PPP2CB binding site. /evidence=ECO:0000250	951..987		6/14 (43%)
		GIT1-binding. /evidence=ECO:0000250\|UniProtKB:Q9R1M7	1062..1095
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156100
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.740