Protein Alignment Ir25a and grik5

DIOPT Version :10

• Sequence 1: NP_001260049.1
• Gene: Ir25a / 33683
• FlyBaseID: FBgn0031634
• Length: 947
• Species: Drosophila melanogaster
• Sequence 2: XP_002936446.1
• Gene: grik5 / 100497490
• XenbaseID: XB-GENE-953974
• Length: 995
• Species: Xenopus tropicalis
• Alignment Length: 989
• Identity: 275/989 - (27%)
• Similarity: 440/989 - (44%)
• Gaps: 193/989 - (19%)

  Fly    11 ILWLLGF----LSLLSSFSLEIAA----QTT----QNINVLF----INEVDNEPAAKAVEVVLTY 59
            :|.||.|    :||||  ||.:||    ||.    :.:.:..    ||......|:..|||.:..
 Frog    11 LLLLLSFTSPGVSLLS--SLRVAAILDDQTVCGRGERLALALAREHINSHTQGSASGRVEVEIFE 73

  Fly    60 LKKNIRYGLSVQLDSIEANKSDAKVLLEAICNKYATSIE----KKQTPHLILDTTKSGIASETVK 120
            |:|:.:|..:..:..| ..|....||..:.....|:::.    :|:.||:     |.| ..|..|
 Frog    74 LQKDSQYETTDTMCQI-LPKGVVSVLGPSTSPASASTVSHICGEKEIPHI-----KVG-PEEAPK 131

  Fly   121 SFTQALGLPTISASYGQQGD--------LRQWRD----LDEAKQKYLLQVMPPADIIPEAIRSIV 173
              .|.|...::|. |....|        |:.:.:    |..||.:.||:       :.|.:|..:
 Frog   132 --LQYLRFASVSL-YPSNEDISLAVSHILKSFHNPSTSLICAKAECLLR-------LEELVRQFL 186

  Fly   174 IHMNITNAAILYDDSFVMDHKYKSLLQNIQTRHVITAIAKDGKREREEQIEKLRNLDINNF---F 235
            |..:..:..:| |:|    :....||:.|:...|.|.|...........::|...|.:.:.   :
 Frog   187 ISKDTLSVRML-DES----NDPTPLLKEIRDDKVSTIIIDANATVSHLILKKASELGMTSAHYKY 246

  Fly   236 ILGTLQSIRMVLESVKPAYFERNFAWHAITQNEGEISSQRDNATIMFMKPMAYTQYRDRLGLLRT 300
            ||.|:....:.||.                     |.|.:.|.....|...::..|.:.|..|..
 Frog   247 ILTTMDFPLLSLEG---------------------IVSDQSNILGFSMYNSSHPFYLEFLRSLNM 290

  Fly   301 TYNLNEE------PQLSSAFYFDLALRSFLTIKEMLQS---GAWPKDMEYLNCDDFQGGNTPQRN 356
            ::..|.|      |.||:|..||........::|:.:|   |     ::.|:|...|   ..|..
 Frog   291 SWRENCELSTYLGPALSAALMFDAVHVVVSAVRELNRSQEIG-----VKQLSCSTSQ---IWQHG 347

  Fly   357 LDLRDYFTKITEPTSYGTFDLVTQSTQPFNGHSFMKFEMDINVLQIRGGSSVNSKSIGKWIS--- 418
            ..|.:|...:       .:|.:|...: ||... .:....:.:|:..|.   ..:.||.|.|
 Frog   348 TSLMNYLRMV-------EYDGLTGRVE-FNSKG-QRTNYTLRILEKAGD---GHREIGVWYSNRT 400

  Fly   419 -GLN-SELIVKDEEQMKNLTADTVYRIFTVVQAPFIMRDE-----TAPKGYKGYCIDLINEIAAI 476
             .:| :.|.:...|.::|.|    ..:.|:::.|::||..     :....|:|:|.:::.|:||:
 Frog   401 LAMNATSLDLSTSETLENKT----LVVTTILENPYMMRKSNYRSLSGNDQYEGFCAEMLMELAAL 461

  Fly   477 VHFDYTIQEVEDGKFGNMDENGQWNGIVKKLMDKQADIGLGSMSVMAEREIVIDFTVPYYDLVGI 541
            :.|:|.|:.||||.:|..:.||.|.|:|.:|::::||:.:.:.::.||||.||||:.|:..| ||
 Frog   462 LRFNYKIKLVEDGLYGAPEPNGSWTGMVGELINRKADLAVAAFTITAEREKVIDFSKPFMTL-GI 525

  Fly   542 TIM--MQRPSSPSSLFKFLTVLETNVWLCILAAYFFTSFLMWIFDRWSPYSYQNN----REKYKD 600
            :|:  :|....| ..|.||......|||.:|.||...|.::::..|.|||.:.|.    ||::..
 Frog   526 SILYRVQMGRKP-GYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRERHHI 589

  Fly   601 DEEKREFNLKECLWFCMTSLTPQGGGEAPKNLSGRLVAATWWLFGFIIIASYTANLAAFLTVSRL 665
            .|  .::.|...|||.:.....||....|:.||.|.|:..||.|..|||:||||||||||||.|:
 Frog   590 LE--NQYTLGNSLWFPVGGFMQQGSEVMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRM 652

  Fly   666 DTPVESLDDLAKQYKILYAPLNGSSAMTYFERMSNIEQMFYEIWKDLSLNDSLTAVERSKLAVWD 730
            :.|:||.||||.|..|.|..::|.|.||:|:...      |:
 Frog   653 EVPIESADDLADQTNIEYGTIHGGSTMTFFQNSR------YQ----------------------- 688

  Fly   731 YPVSDKYTKMWQAMQEAKLPA----TLDEAVARVRNSTAATGFAFLGDATDIRYLQLTNCDLQVV 791
                 .|.:||..| .:|.|:    :.:|.:|||.||.    :|||.::|...|.:..||:|..:
 Frog   689 -----TYQRMWNYM-NSKQPSVFVKSTEEGIARVLNSR----YAFLLESTMNEYHRRLNCNLTQI 743

  Fly   792 GEEFSRKPYAIAVQQGSHLKDQFNNAILTLLNKRQLEKLKEKWWKNDEALAKCDKPED-QSDGIS 855
            |.....|.|.|.:..||..:|:...|||.|....:||.||.|||:.    .||.|.|| ::.|:.
 Frog   744 GGLLDTKGYGIGMPLGSPYRDEITLAILQLQENNRLEILKRKWWEG----GKCPKEEDHRAKGLG 804

  Fly   856 IQNIGGVFIVIFVGIGMACITLVFEYWWYRYRKNPRIIDVAEANAERSNAADHPGKLVDGVILGH 920
            ::||||:|:|:..|:.:|....:.|:.|    ...|.:|    |.|.|...:...:|...|
 Frog   805 MENIGGIFVVLICGLIIAVFVAIMEFVW----STRRSVD----NEEISVCQEMLSELRSAV---- 857

  Fly   921 SGEKFEKSKAALRP 934
            |.:|..:|:...||
 Frog   858 SCKKTSRSRHRRRP 871

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	37..418	CDD:380606	84/412 (20%)
		PBP2_iGluR_putative	438..836	CDD:270435	142/412 (34%)
grik5	XP_002936446.1	PBP1_iGluR_Kainate_KA1_2	27..405	CDD:380616	91/440 (21%)
		Periplasmic_Binding_Protein_Type_2	418..788	CDD:473866	144/416 (35%)