Protein Alignment Ir25a and grik1

DIOPT Version :10

• Sequence 1: NP_001260049.1
• Gene: Ir25a / 33683
• FlyBaseID: FBgn0031634
• Length: 947
• Species: Drosophila melanogaster
• Sequence 2: XP_004912220.1
• Gene: grik1 / 100493949
• XenbaseID: XB-GENE-957124
• Length: 928
• Species: Xenopus tropicalis
• Alignment Length: 1023
• Identity: 270/1023 - (26%)
• Similarity: 439/1023 - (42%)
• Gaps: 238/1023 - (23%)

  Fly    14 LLGFLSLLSSFSLEIAAQTTQNINVLFINEVDNEP---AAKAVEVVLTYLKKN--------IRYG 67
            ||.||..|::.:.: |:|....|..:| ..|:|||   ...|.:..:|.:.:|        :.|.
 Frog    26 LLPFLCALAAITPQ-ASQQVLRIGGIF-ETVENEPINVEELAFKFAVTNINRNRTLMPNTTLTYD 88

  Fly    68 LS-VQL-DSIEANKSDAKVLLEAICNKYATSIEKKQTPHLILDTTKSGIASETVKSFTQALGLPT 130
            :. :.| ||.||::        ..|::.|..:.....|     :..|.:::  |:|...||.:|.
 Frog    89 IQRINLFDSFEASR--------RACDQLALGVAALFGP-----SHSSSVSA--VQSICNALEVPH 138

  Fly   131 ISASYGQQGDLRQWR--DLDEAKQKYLLQVMPPADIIPEAIRSIVIHMNITNAAILYDDSFVMDH 193
            |..         :|:  .:|. |..:.:.:.|....|..|:..:|:|.:.....::|:||..:
 Frog   139 IQT---------RWKHPSVDN-KDSFFINLHPDYAAISRAVLELVLHYSWKTVTVVYEDSTGL-- 191

  Fly   194 KYKSLLQNIQTRHVITAIAKDGKREREEQIEKLRNLDINNFFILGTLQSIRMVLESVKPAYFERN 258
                    |:.:.:|.|.::...:      .|:|.|...|       :..|.:|:.:|.:   |.
 Frog   192 --------IRLQELIKAPSRYNIK------IKIRQLPSGN-------KDARTLLKEMKKS---RE 232

  Fly   259 F--AWHAITQNEGEISSQRDNATIMFMKPMAYTQYRDRLGLLRTTYNLNEEPQLSSAFYFDLALR 321
            |  .:....:...||..|     |:.|            |::...|:           ||...:.
 Frog   233 FYVIFDCSHETAAEILKQ-----ILSM------------GMMTEYYH-----------YFFTTMD 269

  Fly   322 SF-LTIKEMLQSGAWPKDMEYLNCDDFQGGNT------------PQRNLDLRDYFTKITEPTSYG 373
            .| |.::....||........||.|:.|..:.            |:....|.|..........|.
 Frog   270 LFALDLEPYRYSGVNMTGFRLLNIDNPQVSSVVEKWSMERLQAPPKPETGLLDGMMTTDAALMYD 334

  Fly   374 TFDLVTQSTQ----------------PFN-GHSFMK-------------------------FEMD 396
            ...:|..:||                |:. |..||.                         |:||
 Frog   335 AVYMVAVATQRATQMTVSSLQCHRHKPWRFGPRFMSLIKEARWDGLTGRITFNRTDGLRRDFDMD 399

  Fly   397 INVLQIRG-----GSSVNS-----KSIGKWIS--GLNSELIVKDEEQMKNLT---ADTVYRIFTV 446
            |..|:..|     |.:||.     |.:|.|.|  |||....:||:.  .|:|   |:....:.|:
 Frog   400 IISLKEDGMEKAAGETVNHLNKVWKKVGVWNSNTGLNMTDNLKDKS--TNITDSLANRTLIVTTI 462

  Fly   447 VQAPFIM-RDETAP----KGYKGYCIDLINEIAAIVHFDYTIQEVEDGKFGNMDENGQWNGIVKK 506
            ::.|::| |....|    ..::|||:||:.|::.|:.|.|.::.|.|||:|..::.|:|||:|::
 Frog   463 LEDPYVMFRKSDKPLYGNDRFEGYCLDLLKELSNILGFTYEVRLVVDGKYGAQNDKGEWNGMVRE 527

  Fly   507 LMDKQADIGLGSMSVMAEREIVIDFTVPYYDLVGITIMMQRPSSPS-SLFKFLTVLETNVWLCIL 570
            |:|.:||:.:..:::...||.||||:.|:..| ||:|:.::|:..: .:|.||..|..::|:.:|
 Frog   528 LIDHKADLAVAPLTITYVREKVIDFSKPFMTL-GISILYRKPNGTNPGVFSFLNPLSPDIWMYVL 591

  Fly   571 AAYFFTSFLMWIFDRWSPYSYQNNREKYKD-DEEKREFNLKECLWFCMTSLTPQGGGEAPKNLSG 634
            .|....|.::::..|::||.:.|......| |..:..|.|....||.:.:|..||....||.||.
 Frog   592 LACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALST 656

  Fly   635 RLVAATWWLFGFIIIASYTANLAAFLTVSRLDTPVESLDDLAKQYKILYAPLNGSSAMTYFERMS 699
            |:|...||.|..|||:||||||||||||.|:::|::|.||||||.||.|..:...|.||:|
 Frog   657 RIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVRDGSTMTFF---- 717

  Fly   700 NIEQMFYEIWKDLSLNDSLTAVERSKLAVWDYPVSDKYTKMWQAM---QEAKLPATLDEAVARVR 761
                                  ::||::.        |.|||..|   |:..|....||.:.||
 Frog   718 ----------------------KKSKIST--------YEKMWAFMSSRQQTALVKNNDEGIQRV- 751

  Fly   762 NSTAATGFAFLGDATDIRYLQLTNCDLQVVGEEFSRKPYAIAVQQGSHLKDQFNNAILTLLNKRQ 826
               ..|.:|.|.::|.|.|:...||:|..:|.....|.|.:....||..:|:...|||.|..:.:
 Frog   752 ---LTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGK 813

  Fly   827 LEKLKEKWWKNDEALAKCDKPEDQS---DGISIQNIGGVFIVIFVGIGMACITLVFEYWWYRYRK 888
            |..:|||||:.:..      ||:.|   ..:.::||||:|||:..|:.::....:.|: .|:.||
 Frog   814 LHMMKEKWWRGNGC------PEEDSKEASALGVENIGGIFIVLAAGLVLSVFVAIGEF-IYKSRK 871

  Fly   889 NPRIIDVAEANAERSNAADHPGKLVDGVILGHSGEKFEKSKAALRPRF 936
            |..|......||.....         |:.|.|.....:|.||..|..|
 Frog   872 NSDIEQCLSFNAIMEEL---------GISLKHPKRLKKKPKAKGRSSF 910

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	37..418	CDD:380606	87/462 (19%)
		PBP2_iGluR_putative	438..836	CDD:270435	138/407 (34%)
grik1	XP_004912220.1	PBP1_iGluR_Kainate	46..439	CDD:380605	92/472 (19%)
		Periplasmic_Binding_Protein_Type_2	454..823	CDD:473866	138/407 (34%)