DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir25a and grik4

DIOPT Version :9

Sequence 1:	NP_001260049.1	Gene:	Ir25a / 33683	FlyBaseID:	FBgn0031634	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	XP_031761990.1	Gene:	grik4 / 100490768	XenbaseID:	XB-GENE-1011875	Length:	962	Species:	Xenopus tropicalis

Alignment Length:	1004	Identity:	254/1004 - (25%)
Similarity:	427/1004 - (42%)	Gaps:	220/1004 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LMNPKTSKILWLLGFLSLLSSFSLEIAAQTTQNINVLFINEVDNEP--AAKAVEVVLTYLKKNI- 64
            ::.|....:|||   :....|.||.|||             :.::|  .::...:.:|..|..|
Frog     4 VLAPMVLVLLWL---MKSAGSPSLRIAA-------------ILDDPMECSRGERLSITLAKNRIN 52

  Fly    65 ----RYGLS-VQLDSIEANKSDAKVLLEAICN------------KYATSIE--------KKQTPH 104
                |.|.: :::|..|..|.......|.:|.            .|:.|..        :|:.||
Frog    53 RAPERQGKARLEVDIFELLKDSEYETAETMCQILPKGVLGVLGPSYSPSSSSIISNICGEKEVPH 117

  Fly   105 LILDTTKSGIASETVKSFTQALGLPTISASYGQQGDLRQWRDLDEAKQKYLLQVMPPADIIPEAI 169
            :.:.|.:  ......:.||                               .|.:.|....|..|:
Frog   118 IKVSTEE--FLRFQYQRFT-------------------------------TLNLHPSNTDISAAV 149

  Fly   170 RSIVIHMNITNAAILYDDSFVMDHKYKSLLQNIQTRHVITAIAKDGKREREEQIEKLRNLDINNF 234
            .:::...|.|.|.::...:..:.:..|.|.|.:.::..::....|...:....::::|:...:..
Frog   150 ATLLRFFNSTTACLICAKAECLLNLEKLLRQFLISKDCLSVRMLDDTWDPTPLLKEIRDDKTSTI 214

  Fly   235 FILGTLQSIRMVLESVKPAYFERNFAWHAITQNEGEISSQR------DNATI----MFMKPMAYT 289
            .:.........:|  :|.|......|::.......|...||      |...|    ||.:..:|
Frog   215 IVHANASMSHTIL--MKAAELGMVTAYYTYIFTNLEFVLQRFESPLDDRVNILGFSMFNQSHSY- 276

  Fly   290 QYRDRLGLLRTTYNLNEE------PQLSSAFYFDLALRSFLTIKEMLQS---GAWPKDMEYLNCD 345
             :::....|:.::..|.:      |.||:|..||........::|:.:|   |..|     |:|.
Frog   277 -FKEFAHTLQQSWEENCDHSPFTGPALSAALLFDAVYGIVSAVQELNRSQEIGVKP-----LSCG 335

  Fly   346 DFQGGNTPQRNLDLRDYFTKITEPTSYGTFDLVTQSTQPFNGH-----SFMKFEMDINVLQIRGG 405
            ..|   ..|....|.:|...:              ..:...||     ...:...|:.::|.
Frog   336 SSQ---IWQHGTSLMNYLRMV--------------ELEGLTGHVEFNSKGQRSNYDMKIMQY--- 380

  Fly   406 SSVNSKSIGKW--ISGLN----------SELIVKDEEQMKNLTADTVYRIFTVVQAPFIM----- 453
            :....:.||:|  .:|||          |:.:|.     |.|...|:  :|.:.:.|::|
Frog   381 TKTGFQEIGQWHVTNGLNMDKRYFSPNASDTLVN-----KTLIVTTI--LFFLQENPYLMLKANH 438

  Fly   454 RDETAPKGYKGYCIDLINEIAAIVHFDYTIQEVEDGKFGNMDENGQWNGIVKKLMDKQADIGLGS 518
            ::......|:|:|:|::.|:|||:.|:|.|:.|.||.:|..:.||.|.|:|.:|:.::||:.:..
Frog   439 QELEGNDRYEGFCVDMLKELAAILRFNYKIRLVADGVYGVPELNGTWTGMVGELISRKADLAVAG 503

  Fly   519 MSVMAEREIVIDFTVPYYDLVGITI-----MMQRPSSPSSLFKFLTVLETNVWLCILAAYFFTSF 578
            :::.||||.||||:.|:..| ||:|     |.::|    ..|.||......|||.:|.||...|.
Frog   504 LTITAEREKVIDFSKPFMTL-GISILYRVHMGRKP----GYFSFLDPFSPGVWLFMLLAYLAVSC 563

  Fly   579 LMWIFDRWSPYSYQNNR--EKYKDDEEKREFNLKECLWFCMTSLTPQGGGEAPKNLSGRLVAATW 641
            ::::..|.:||.:.:..  .:.:.:....:::|...|||.:.....||...||:.||.|.|:..|
Frog   564 VLFLVARLTPYEWYSPHPCAQGRCNLLVNQYSLGNSLWFPVGGFMQQGSTIAPRALSTRCVSGVW 628

  Fly   642 WLFGFIIIASYTANLAAFLTVSRLDTPVESLDDLAKQYKILYAPLNGSSAMTYFERMSNIEQMFY 706
            |.|..|||:||||||||||||.|:|.|:||:||||.|..|.|..::|.|:||:|:...      |
Frog   629 WAFTLIIISSYTANLAAFLTVQRMDVPIESVDDLADQTTIEYGTIHGGSSMTFFQNSR------Y 687

  Fly   707 EIWKDLSLNDSLTAVERSKLAVWDYPVSDKYTKMWQAMQEAKLPA----TLDEAVARVRNSTAAT 767
            :                            .|.:||..| .:|.|:    :.:|.:|||.||
Frog   688 Q----------------------------TYQRMWNYM-HSKQPSVFVKSTEEGIARVLNS---- 719

  Fly   768 GFAFLGDATDIRYLQLTNCDLQVVGEEFSRKPYAIAVQQGSHLKDQFNNAILTLLNKRQLEKLKE 832
            .:|||.::|...|.:..||:|..||.....|.|.|.:..||..:|:|:.|||.|.....||.||.
Frog   720 NYAFLLESTMNEYYRQRNCNLTQVGGLLDTKGYGIGMPVGSAFRDEFDLAILQLQENNCLEDLKR 784

  Fly   833 KWWKNDEALAKCDKPED-QSDGISIQNIGGVFIVIFVGIGMACITLVFEY-WWYRYRKNPRIIDV 895
            |||..    .||.|.|| ::.|:.::||||:|:|:..|:.:|.:..:.|: |..|..::..:...
Frog   785 KWWDG----GKCPKEEDHRAKGLGMENIGGIFVVLICGLIVAILIAMLEFLWTVRNAEDSEVSVC 845

  Fly   896 AEANAERSN---AADH--PGKLVDGVILG 919
            .|..:|.|:   ..|.  |.:...|||.|
Frog   846 QEMASELSSIILCKDSFLPRRRRGGVIRG 874

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	40..426	CDD:107378	72/449 (16%)
		PBP2_iGluR_putative	438..836	CDD:270435	142/413 (34%)
		Lig_chan	565..870	CDD:278489	110/311 (35%)
grik4	XP_031761990.1	Periplasmic_Binding_Protein_type1	23..400	CDD:415822	76/451 (17%)
grik4	XP_031761990.1	PBP2_iGluR_kainate_KA1	414..788	CDD:270442	144/424 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010