Protein Alignment Ir25a and grin2a

DIOPT Version :10

• Sequence 1: NP_001260049.1
• Gene: Ir25a / 33683
• FlyBaseID: FBgn0031634
• Length: 947
• Species: Drosophila melanogaster
• Sequence 2: XP_031749422.1
• Gene: grin2a / 100489006
• XenbaseID: XB-GENE-992741
• Length: 1450
• Species: Xenopus tropicalis
• Alignment Length: 1011
• Identity: 207/1011 - (20%)
• Similarity: 374/1011 - (36%)
• Gaps: 311/1011 - (30%)

  Fly    15 LGFLSLLSSFSLEIAAQTTQ---------NINVL-----FINEVDNEPAAKAVEVVLTYLKKNIR 65
            :|..:|| .::|..|....|         ||.|:     :|.|.|          :.:...:::.
 Frog     1 MGIFALL-LYTLLYAGDLGQGAEKSFPVLNIAVILGRTRYITERD----------IRSLWTRDMS 54

  Fly    66 YGLSVQLDSIEANKSDAKVLLEAICNKYA-TSIEKKQTPHLIL---DTTKSGIAS----ETVKSF 122
            ....|.:.::..|::|.|.::..:|:..: |.|      |.::   ||.:..||.    .:.::|
 Frog    55 LDFDVNVVTLLVNQTDPKSIITHVCDLMSGTKI------HGVVFGDDTDQEAIAQILDFVSSQTF 113

  Fly   123 TQALGLPTISASYGQQGDLRQWRDLDE----------AKQK--YLLQVMPPAD-----IIPEAI- 169
            ...||:      :|  |......|.||          .||:  .:|.:|...|     ||....
 Frog   114 IPILGI------HG--GSSMIMADKDEMSTFFQFGASIKQQAIVMLNIMEEYDWHVFSIITSTFP 170

  Fly   170 --RSIVIHMNITNAAILYDDSFV---------MDHKYK-----SLLQNIQTRHVITAIAKDGKRE 218
              |..:..:..|     .|:|||         :|..|.     :.|:.|.:..::...:||   |
 Frog   171 GYRDFISFIKTT-----VDNSFVGWEVQNVITLDTSYTDARTLTQLKKIHSSVILLYCSKD---E 227

  Fly   219 REEQIEKLRNLDINNFFILGTLQSIRMVLESVKPAYFERNFAWHAITQNEGEISSQRDNATIMFM 283
            ......:.|:|.:..:..:..:.|:......:.|..|.....  :::.::.:.:.:
 Frog   228 ANYIFVEARSLGLMGYGFVWIVPSLVTGNTDIIPYEFPSGLV--SVSYDDWDYNIE--------- 281

  Fly   284 KPMAYTQYRDRLGLLRTT------------------YNLNE--EPQLSSAFYFDLALRSFLTIKE 328
                 .:.||.||::.|.                  |..||  ||.|.             |:.:
 Frog   282 -----ARVRDGLGIITTAASAMLEKHSVIPEAKTSCYAQNERNEPPLH-------------TLHK 328

  Fly   329 MLQSGAWP-KDMEYLNCDDFQGGNTPQ-----RNLDLRDYFTKITEPTSYGTFDLVTQSTQPFNG 387
            .:.:..|. ||:.:.. |.:|.  .|:     .|:| |::
 Frog   329 FMINVTWDGKDLSFTE-DGYQA--NPKLVVLLLNMD-REW------------------------- 364

  Fly   388 HSFMKFEMDINVLQIRGGSSVNSKSIGKWIS-GLNSELIVKDEEQMKNLTA-------DTVYRIF 444
                                   :.:|||.: .||.:..|     ...:||       |....|.
 Frog   365 -----------------------EKVGKWENKSLNMKYPV-----WPRITASLDSDPDDNHLSIV 401

  Fly   445 TVVQAPFIMRD-----------ETAP------------------KGYKGYCIDLINEIAAIVHFD 480
            |:.:|||::.:           .|.|                  |..||:|||::.:::..|.|.
 Frog   402 TLEEAPFVIVENVDYLTGTCVRNTVPCRKYFRLNNSTTEGTSVKKCCKGFCIDILKKLSKTVKFT 466

  Fly   481 YTIQEVEDGKFGNMDENGQWNGIVKKLMDKQADIGLGSMSVMAEREIVIDFTVPYYDLVGITIMM 545
            |.:..|.:||.|...:| .|||::.:::.|:|.:.:||:::..||...:||:||:.: .||::|:
 Frog   467 YDLYLVTNGKHGKKIKN-VWNGMIGEVVYKRAVMAVGSLTINEERSEAVDFSVPFVE-TGISVMV 529

  Fly   546 QRPSSPSSLFKFLTVLETNVWLCILAAYFFTSFL-MWIFDRWSPYSYQNNREKYKDDEEKREFNL 609
            .|.:...|...||.....:||:.:.......|.: :::|:.:||..|..|....|..... .|.:
 Frog   530 SRSNGTVSPSAFLEPFSASVWVMMFVMLLLVSAVAVFVFEYFSPVGYNRNLADGKAPHGP-SFTI 593

  Fly   610 KECLWFCM-----TSLTPQGGGEAPKNLSGRLVAATWWLFGFIIIASYTANLAAFLTVSRLDTPV 669
            .:.:|...     .|:..|.    ||..:.:::.:.|..|..|.:||||||||||:........|
 Frog   594 GKAVWLLWGLVFNNSVPVQN----PKGTTSKIIVSIWAFFAVIFLASYTANLAAFMIQEEFVDQV 654

  Fly   670 ESLDDLAKQYKILYAP-------LNGSSAMTYFERMSNIEQMFYEIWKDLSLNDSLTAVERSKLA 727
            ..|.|...|....|:|       .|||:.........::.|...: :....:.|:|.:::..||.
 Frog   655 TGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPDMHQYMVK-FHQKGVQDALVSLKTGKLD 718

  Fly   728 VWDYPVSDKYTKMWQAMQEAKLPATLDEAVARVRNSTAATGFAFLGDATDIRYL--QLTNCDLQV 790
                                                      ||:.||..:.|:  :...|.|..
 Frog   719 ------------------------------------------AFIYDAAVLNYMAGRDEGCKLVT 741

  Fly   791 VGEE--FSRKPYAIAVQQGSHLKDQFNNAILTLLNKRQLEKLKEKWWKNDEALAKCDKPEDQSDG 853
            :|..  |:...|.||:|:||..|...:.|:|..:...::|:|::.|.   ..:...:|.|..|..
 Frog   742 IGSGYIFATTGYGIALQKGSRWKRPIDLALLQFVGDGEMEELEKLWL---TGICHTEKNEVMSSQ 803

  Fly   854 ISIQNIGGVFIVIFVGIGMACITLVFE---YWWYRY 886
            :.|.|:.|||.::...:.::.||.|:|   ||..||
 Frog   804 LDIDNMAGVFYMLAAAMALSLITFVWEHLFYWKLRY 839

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	37..418	CDD:380606	73/453 (16%)
		PBP2_iGluR_putative	438..836	CDD:270435	105/443 (24%)
grin2a	XP_031749422.1	PBP1_iGluR_NMDA_NR2	26..379	CDD:380601	77/465 (17%)
		PBP2_iGluR_NMDA_Nr2	395..793	CDD:270436	105/450 (23%)
		NMDAR2_C	831..1450	CDD:463148	4/9 (44%)