DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir25a and grid2

DIOPT Version :9

Sequence 1:	NP_001260049.1	Gene:	Ir25a / 33683	FlyBaseID:	FBgn0031634	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	XP_031759030.1	Gene:	grid2 / 100487676	XenbaseID:	XB-GENE-955038	Length:	1007	Species:	Xenopus tropicalis

Alignment Length:	942	Identity:	207/942 - (21%)
Similarity:	396/942 - (42%)	Gaps:	181/942 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 TQNINVLFINEVDNEPAAKAVEVVLTYLKKNIRYGLSVQLDSIEANKSDAKV----------LLE 87
            |:..:::.|..:.:|.|.|..||....:.     .|::..|.::..|....|          .::
Frog    21 TRADSIIHIGAIFDESAKKDDEVFRMAVA-----DLNLNEDILQTEKITFSVTFVDGNNPFQAVQ 80

  Fly    88 AICNKYATSIEKKQTPHLILDTTKSGIASETVKSFTQALGLPTI-----SASYGQQG-DLRQWRD 146
            ..|:..:..|       |.|.::....::.:::|...|:.:|.:     :|...:.| .|::...
Frog    81 EACDLMSQGI-------LALVSSIGCASAGSLQSLADAMHIPHLFIQRSTARTPRSGCGLQRSSG 138

  Fly   147 LDEAKQKYLLQVMPPADIIPEAIRSIVIHMNITNAAILYDDSFVMDHKYKSLLQNIQTRHVITAI 211
            :|:    |.|.|.||. .:.:.|..:|.........:.||:::.        ::.||  ..:..:
Frog   139 IDD----YTLSVRPPV-YLNDVILRVVTEYAWQKFIVFYDNNYD--------IRGIQ--EFLDRV 188

  Fly   212 AKDGKREREEQIEKLRNLDINNFFILGTLQSIRMVLESVKPAYF---------------ERNFA- 260
            ::.|.....:::|...|..|...|....::.:....::::.|..               |.|..
Frog   189 SQQGMDVALQKVENNINRMITGLFATMRIEELNRYRDTLRRAILVMSPTTAKAFITEVVETNLVA 253

  Fly   261 ----WHAITQNEGEISSQR------DNATIM---FMKPMAYTQ------YRDRLGLLRTTYNLNE 306
                |..|.:...::..|.      ...||:   |..|...:|      :|....|.......::
Frog   254 FDCHWIIINEEINDLDVQELVRRSIGRLTIIRQTFPVPHNSSQRCFRGNHRISTSLCDPKDPFSQ 318

  Fly   307 EPQLSSAFYFDLALRSFLTIKEMLQSGAWPKDMEYLNC-----DDFQGGNTPQRNLDLRDYFTKI 366
            ..::::.:.:|..|.......:.|:...| ..|..|.|     ..:|||.:             :
Frog   319 NMEITNMYIYDTVLLLANAFHKKLEDRKW-HSMASLTCIRKNSKPWQGGRS-------------M 369

  Fly   367 TEPTSYGTFDLVTQSTQPFN---GHSFMKFEMDINVLQIRGGSSVNS--KSIGKW--ISGLNSEL 424
            .|....|....:|.:.. |:   |:..:.||    :|....|..:..  :.:|.|  ::|||..|
Frog   370 LETVKKGGVSGLTGALD-FSEDGGNPNIYFE----ILGTNYGEELGRGIRKLGFWNPVTGLNGSL 429

  Fly   425 IVKDEEQMKNLTADTVYRIFTVVQAPFIMRDETA---PKGYKGYCIDLINEIAAIVHFDYTIQEV 486
               .:.:::|.....|.|:.||::.||:|..|..   ||.|:|:.||:::.:::.:.|.|.|...
Frog   430 ---TDRKLENNMRGVVLRVATVLEEPFVMVSENVLGKPKKYQGFSIDVLDALSSYLGFKYEIYVA 491

  Fly   487 EDGKFGNMDENGQWNGIVKKLMDKQADIGLGSMSVMAEREIVIDFTVPYYDLVGITIMMQRPSSP 551
            .|.|:|:...:|.|||::.:|:.|:||:|:.::::..:||.|:|||..|.| ..:.:::::....
Frog   492 SDHKYGSPQADGSWNGLIGELLLKRADMGISALTITPDRENVVDFTTRYMD-YSVGVLLRKAEKT 555

  Fly   552 SSLFKFLTVLETNVWLCILAAYFFTSFLMWIFDRWSPYSYQNNREKYKDDEEKREFNLKECLWFC 616
            ..:|..|...:.::|.||.........|:::.:..:|...|..        ......|...:||.
Frog   556 VDMFACLAPFDLSLWACIAGTVLLVGLLVYLLNWLNPPRLQMG--------SMTSTTLYNSMWFV 612

  Fly   617 MTSLTPQGGGEAPKNLSGRLVAATWWLFGFIIIASYTANLAAFLTVSRLDTPVESLDDLAKQYKI 681
            ..|...|||......|:.|::...||||..|:|:|||||||||||:||:::.::||.||::|..|
Frog   613 YGSFVQQGGEVPYTTLATRMMMGAWWLFALIVISSYTANLAAFLTISRIESSIQSLQDLSRQTDI 677

  Fly   682 LYAPLNGSS--------AMTYFERMSNIEQMFYEIWKDLS-LNDSLTAVERSKLAVWDYPVSDKY 737
            .|..:..|:        .|..|||    :.|:.::|:.:: .|.|...|:.|.
Frog   678 PYGTVFDSAVYEHVRVKGMNPFER----DSMYSQMWRMINRSNGSENNVQESL------------ 726

  Fly   738 TKMWQAMQEAKLPATLDEAVARVRNSTAATGFAFLGDATDIRYLQLT--NCDLQVVGEEFSRKPY 800
                             |.:.:|::.    .:||:.||..:.|:.:.  :|....||...:.:.|
Frog   727 -----------------EGIQKVKHG----NYAFVWDAAVLEYIAINDQDCSFYTVGNTIADRGY 770

  Fly   801 AIAVQQGSHLKDQFNNAILTLLNKRQLEKLKEKWWKNDEALAKCD-----KPEDQSDGISIQNIG 860
            .||:|.||..:|.|:..||.|.....::.||.|||..:   .:|:     ..:.:...:.|::..
Frog   771 GIALQHGSPYRDIFSQRILELQQNGDMDILKHKWWPRN---GQCELHSSMDTKQKGSSLDIKSFS 832

  Fly   861 GVFIVIFVGIGMACITLVFEYWWYRYRKNPRI 892
            |||.::..||.::|...:.|.||.: :|..|:
Frog   833 GVFCILAAGIVLSCFIAMVETWWNK-KKGSRV 863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	40..426	CDD:107378	75/448 (17%)
		PBP2_iGluR_putative	438..836	CDD:270435	116/411 (28%)
		Lig_chan	565..870	CDD:278489	83/320 (26%)
grid2	XP_031759030.1	Periplasmic_Binding_Protein_type1	28..429	CDD:415822	74/446 (17%)
grid2	XP_031759030.1	PBP2_iGluR_delta_2	440..806	CDD:270449	116/411 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910