DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir25a and LOC100334689

DIOPT Version :9

Sequence 1:	NP_001260049.1	Gene:	Ir25a / 33683	FlyBaseID:	FBgn0031634	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	XP_017206939.1	Gene:	LOC100334689 / 100334689	-ID:	-	Length:	991	Species:	Danio rerio

Alignment Length:	941	Identity:	248/941 - (26%)
Similarity:	422/941 - (44%)	Gaps:	214/941 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 AVEVVLTYLKKNIRYGLSVQLDSIEANKSDAKVLL---EAICNKYA-TSIEKKQT--PHLIL--- 107
            |:.|||.:::.:......:::..| ..::|..|.|   |.:..|:| .:|.:.:|  |:..|
Zfish    13 AIIVVLFWIQSSFGMPHVIRIGGI-FEQTDGPVALVSSEELAFKFAVNNINRNRTLLPNTTLTYD 76

  Fly   108 -----------------DTTKSGI----------ASETVKSFTQALGLPTISASYGQQGDLRQWR 145
                             |....|:          :|..|:|...||.:|.|..         :|:
Zfish    77 IQRINIYDSFEASRKACDQLSLGVVAIFGPSHSSSSNAVQSICNALEVPHIQV---------RWK 132

  Fly   146 --DLDEAKQKYLLQVMPPADIIPEAIRSIVIHMNITNAAILYDDS---------------FVMDH 193
              .:|. :..:...:.|....:..||..:|..:....|.::||||               :.:..
Zfish   133 HHPMDN-RDTFYANLYPDYSSLSYAILDLVQFLKWKTATVVYDDSTGLIRLQELIMAPSRYNIRL 196

  Fly   194 KYKSL-LQNIQTRHVITAIAKDGKREREEQIEKLRNLDINNFF---ILGTLQSIRMVLESVKPAY 254
            |.:.| :..:.||.::    |:.||.||.:|    ..|.::..   ||...|.:.|:.|     |
Zfish   197 KIRQLPMDTVDTRPLL----KEMKRSREFRI----IFDCSHTMAAQILKQAQMMGMMTE-----Y 248

  Fly   255 FERNFAWHAITQNEGEISSQRDNATIMFMKPMAYTQYRDRLGLLRTTYN-LN-EEPQLSSAFYFD 317
            :...|                   |.:.:..:....|| ..|:..|.:. || :.||::|
Zfish   249 YHYIF-------------------TTLDLMAINLEPYR-FCGVNMTGFRILNVDNPQVAS----- 288

  Fly   318 LALRSFLTIKEMLQSGAWPK------------------DMEYLNCDDFQGGNTPQRNLD-LRDYF 363
                  :..|..|:....||                  |..::....:|  :.||..:: |:.:.
Zfish   289 ------IVEKWSLERQIPPKPDSGLLEGIMTTDAALTYDAVHIVSVSYQ--HAPQMTVNSLQCHR 345

  Fly   364 TKITEPTSYG--TFDLVTQSTQP-------FNGHSFMKFEMDINVLQIRGGSSVNSKSIGKWIS- 418
            .|   |..:|  ....:.:|...       ||..:.::.:.|::::.::   ....:.:|||.:
Zfish   346 HK---PWRFGGRFMSFIKESHWDGLTGRLCFNRTTGLRTDFDLDIVSLK---EDGLQKVGKWSAS 404

  Fly   419 -GLNSELIVKDEEQMKNLTADTVYR---IFTVVQAPFIM--RDETAPKG---YKGYCIDLINEIA 474
             |||...:.:  :...|:|.....|   |.|:::.|::|  :.:.|..|   ::|:||||:.|:|
Zfish   405 GGLNITEVPR--QNGMNITDSLSNRSLVITTILEEPYVMLKKSDKALVGNDRFEGFCIDLLKELA 467

  Fly   475 AIVHFDYTIQEVEDGKFGNMDENGQWNGIVKKLMDKQADIGLGSMSVMAEREIVIDFTVPYYDLV 539
            :|:.|.|.|..|.|||:|..|:.|||||::::||:.:||:.:..:::...||..|||:.|:.: .
Zfish   468 SILGFSYEIHLVPDGKYGFQDDKGQWNGMIRELMEHRADLAVAPLTITFMREKAIDFSKPFLN-T 531

  Fly   540 GITIMMQRPSSPSS-LFKFLTVLETNVWLCILAAYFFTSFLMWIFDRWSPYS-YQNNREKYKDDE 602
            ||:|:.::|:|.:| .|.||..:..::|:.||.||...|.::::..|:|||. |..:......|.
Zfish   532 GISILYRKPNSTNSGFFSFLNPMTPDIWVYILLAYLGVSCVLFVIARFSPYEWYDAHPCNPGSDV 596

  Fly   603 EKREFNLKECLWFCMTSLTPQGGGEAPKNLSGRLVAATWWLFGFIIIASYTANLAAFLTVSRLDT 667
            .:..|.|....||.:.||..||....||.||.|::...||.|..|||:||||||||||||.|:|:
Zfish   597 VENNFTLLNSFWFGVGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMDS 661

  Fly   668 PVESLDDLAKQYKILYAPLNGSSAMTYFE--RMSNIEQMFYEIWKDLSLNDSLTAVERSKLAVWD 730
            ||:|.||||||.||.|..:...:.|::|:  |:|..|:|    |..:|...|.:.|:
Zfish   662 PVDSADDLAKQTKIEYGVVKDGATMSFFKKSRVSTFEKM----WAFMSSRQSTSFVK-------- 714

  Fly   731 YPVSDKYTKMWQAMQEAKLPATLDEAVARVRNSTAATGFAFLGDATDIRYLQLTNCDLQVVGEEF 795
                                 ::::.:.||..|    .:|.|.::|.|.|:...||:|..||...
Zfish   715 ---------------------SIEDGIQRVLKS----DYALLMESTTIEYVTRRNCNLTQVGGII 754

  Fly   796 SRKPYAIAVQQGSHLKDQFNNAILTLLNKRQLEKLKEKWWKNDEALAKCDKPED---QSDGISIQ 857
            ..|.|.|...:||..:|:...|||.:|...:|..||||||.....|      ||   ::..:.||
Zfish   755 DSKGYGIGTPKGSPYRDKITIAILGILEDGRLHMLKEKWWSGSSCL------EDERYETGPMGIQ 813

  Fly   858 NIGGVFIVIFVGIGMACITLVFEYWWYRYRK 888
            |:||:|||:..|:.::....:.|: .|:.||
Zfish   814 NLGGIFIVLASGLVLSVFVAIGEF-IYKLRK 843

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	40..426	CDD:107378	85/462 (18%)
		PBP2_iGluR_putative	438..836	CDD:270435	144/409 (35%)
		Lig_chan	565..870	CDD:278489	108/310 (35%)
LOC100334689	XP_017206939.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591819
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.740