DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir25a and grin2cb

DIOPT Version :9

Sequence 1:	NP_001260049.1	Gene:	Ir25a / 33683	FlyBaseID:	FBgn0031634	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	XP_009305071.2	Gene:	grin2cb / 100333648	ZFINID:	ZDB-GENE-100308-2	Length:	1328	Species:	Danio rerio

Alignment Length:	1080	Identity:	209/1080 - (19%)
Similarity:	389/1080 - (36%)	Gaps:	330/1080 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 SLLSSFSLEIAAQTTQNINVLFINEVDNEPAAKAVEVVLTYLKKNIRYGLSVQLDSIEANKSDAK 83
            :||:.....:||::..  .|:|.::||:|..|:.::.|.:.....| .|:|.....:..:|:|..
Zfish    84 ALLTRLCQTMAAESLH--GVVFEDDVDSEAVAQILDFVSSQTSIPI-VGISGGSAVVIPHKADGS 145

  Fly    84 VLLE--AICNKYATSIEKKQTPH-----LILDTTKSGIAS--ETVKSFT-------QALGLPTIS 132
            ..|:  |..::...::.|....:     :::.:...|..:  :.::|||       :...:.:..
Zfish   146 TFLQMGASIDQQINAMFKVMEEYNWGNFVVITSLYPGYETFVDYIRSFTDTSYFLWELQDVLSFE 210

  Fly   133 ASYGQQGDLRQWRDLDEA------------KQKYLLQVMPPADIIPEAIRSIVIHMNITNAAILY 185
            .|.| ..|:|..|.|.:.            :.:||.::.....::......||..:.:.|.....
Zfish   211 MSVG-ANDIRTRRLLQQVDSQVYLVYCSHEEAQYLFRMASDVGLLGPGYIWIVPSLAVGNPEAAP 274

  Fly   186 DDSF-------VMDHKYKSLLQNIQTRHVITAIAKDGKREREEQIEKLRNLDINNFFILGTLQSI 243
            ..||       :.|...|:|.|.::                                     :.:
Zfish   275 PASFPVGVISIITDRWRKTLRQRVR-------------------------------------EGV 302

  Fly   244 RMVLESVKPAYFERNFAWHAITQNEGEISSQRDNATIMFMKPMAYTQYRDRLGLLRTTYNLNEEP 308
            .::::.|...:..|.|.....:.....:.|..:|:                  |.|...|::.|
Zfish   303 AIIVKGVHSFHKHRGFIPEGHSDCSSPVKSYANNS------------------LFRHMLNVSWE- 348

  Fly   309 QLSSAFYFDLALRS--FLTIKEML-----QSGAWPKDMEYLNCDDFQGGNTPQRNLDLRDYFTKI 366
                  :.||:..|  :||...|:     :...|.|      ...::|| ..|....:...:...
Zfish   349 ------HKDLSFNSDGYLTNPSMVIIALDRENHWDK------VGSYEGG-ILQMRYPVWPRYGSF 400

  Fly   367 TEPTS------YGTFD----LVTQSTQPFNGHSFMKFEMDINVLQIRGGSSVNSKSIGKWISGLN 421
            .||.|      ..|.:    ::.:|..|..|....      |.:..|..|:             .
Zfish   401 LEPVSDNRHLTVATLEERPFVIVESVDPATGTCVR------NTVPCRRQSN-------------R 446

  Fly   422 SELIVKDEEQMKNLTADTVYRIFTVVQAPFIMRDETAPKGYKGYCIDLINEIAAIVHFDYTIQEV 486
            :|.|:...|....|..                         ||:|||::.:::..:.|.|.:..|
Zfish   447 TESIIGHTEPYTKLCC-------------------------KGFCIDILKKLSRTIKFSYDLYLV 486

  Fly   487 EDGKFGNMDENGQWNGIVKKLMDKQADIGLGSMSVMAEREIVIDFTVPYYDLVGITIMMQRPSSP 551
            .:||.|.| ..|.|||::.::..|:||:.:||:::..||..::||:||:.: .||::|:.|.:..
Zfish   487 TNGKHGKM-VRGVWNGMIGEVFYKRADMAIGSLTINEERSEIVDFSVPFVE-TGISVMVARSNGT 549

  Fly   552 SSLFKFLTVLETNVW-----LCILAAYFFTSFLMWIFDRWSPYSYQNNREKYKDDEEKREFNLKE 611
            .|...||......||     :|:..    .:..:::|:.:||..|..:....|..... .|.:.:
Zfish   550 VSPSAFLEPYSPAVWVMMFVMCLTV----VAVTVFVFEYFSPVGYNRSLVSAKAPGGP-TFTIGK 609

  Fly   612 CLW----FCMTSLTPQGGGEAPKNLSGRLVAATWWLFGFIIIASYTANLAAFLTVSRLDTPVESL 672
            .:|    ....:..|.   |.||..:.:::...|..|..|.:||||||||||:...:....|..|
Zfish   610 SVWLLWGIVFNNSVPI---ENPKGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTVSGL 671

  Fly   673 DDLAKQY---KILYAPL------NGSSAMTYFERMSNIEQMFYEIWKDLSLNDSLTAVERSKLAV 728
            .|  |::   :..|.|.      |||:     ||  ||..
Zfish   672 SD--KKFQKPQEHYPPFRFGTVPNGST-----ER--NIRS------------------------- 702

  Fly   729 WDYPVSDKYTKMWQAMQEAKLPATLDEAVARVRNSTAATG--FAFLGDATDIRYL--QLTNCDLQ 789
             :||  |.:|.|.:..|:.     ::||:     ::..||  .||:.||..:.|:  :...|.|.
Zfish   703 -NYP--DMHTHMIKYNQKG-----VEEAL-----NSLKTGKLDAFIYDAAVLNYMAGKDEGCKLV 754

  Fly   790 VV--GEEFSRKPYAIAVQQGSHLKDQFNNAILTLLNKRQLEKLKEKWWKNDEALAKCDKPEDQSD 852
            .:  |:.|:...|.||:|:.|..|...:.|:|..|.....::|:..|.   ..:.:.:|.|..|.
Zfish   755 TIGSGKVFATTGYGIALQKDSRWKRPIDLALLQFLGDGDTQRLETVWL---SGICQNEKNEVMSS 816

  Fly   853 GISIQNIGGVFIVIFVGIGMACITLVFE---YWWYRYR--------------------------- 887
            .:.|.|:.|||.::.|.:|::.:...:|   ||..|:.
Zfish   817 KLDIDNMAGVFYMLLVAMGLSLLVFAWEHLLYWKLRHSVHKSDRLDFLLAISRGIYSCFNGVEDI 881

  Fly   888 ------KNPRI-IDVAEAN--------------AERSNAADHPGKLVDG---------------- 915
                  :||.| .:.|:||              |:..|:.|:..|.::.
Zfish   882 GRSTGIQNPDITANYAQANMLKMLQTAKDIVSSAKVENSLDNATKTIENWSRRSGSLPARIPLVT 946

  Fly   916 ---VILGH-------SGEKFEKSKAALRPRFNQYPATFKP 945
               .:.||       :.......:.::.|.|.|:..|..|
Zfish   947 TTEKVPGHFSYIANVAENHIPHMQRSITPPFTQHTTTTSP 986

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	40..426	CDD:107378	66/437 (15%)
		PBP2_iGluR_putative	438..836	CDD:270435	104/421 (25%)
		Lig_chan	565..870	CDD:278489	79/328 (24%)
grin2cb	XP_009305071.2	PBP1_iGluR_NMDA_NR2	37..396	CDD:107373	60/384 (16%)
		PBP2_iGluR_NMDA_Nr2	407..808	CDD:270436	115/504 (23%)
		NMDAR2_C	845..>932	CDD:313729	13/86 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591879
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.830